Возрастная и сезонная изменчивость состава эфирного масла ели европейской

An essential oil from foliage of Picea abies growing at territories removed from technogenic influence, has been obtained by the hydrodistillation method. The essential oil content in foliage has been determined. The composition of the oil has been studied by gas chromatography, and 19 main components with content 1% w/w or higher, have been identified. It has been established that the yield of essential oil depends on age and sampling time of the green mass. Age and seasonal variability of the oil composition has been studied.Методом гидродистилляции получено эфирное масло хвои ели европейской, произрастающей на территории, удаленной от техногенного воздействия. Определено содержание эфирного масла в хвое ели европейской в расчете на а.с.с. Газохроматографическим методом исследован компонентный состав масел. Идентифицировано 19 основных компонентов эфирного масла, содержание которых превышает 1 мас.%. Установлено изменение выхода эфирного масла с возрастом и временем отбора древесной зелени. Изучена возрастная и сезонная изменчивость состава елового масла

Вариабельность основных компонентов эфирного масла пихты одноцветной ( Abies concolor), произрастающей в условиях урбанизированной среды

The chemical composition of essential oil from A. Concolor growing in urban environment has been studied, 48 ingredients being identified and their content measured. The results obtained demonstrate the relationship between certain ingredients’ content and envuironment pollution by toxic elements, that can be used as an indicator of the environment condition.Исследования позволили детально рассмотреть химический состав эфирного масла пихты A. Concolor , произрастающей в условиях урбанизированной среды, идентифицировать и количественно измерить содержание 48 компонентов. Представленные результаты наглядно демонстрируют зависимость содержания отдельных компонентов в масле от степени загрязненности территории произрастания токсичными элементами и могут использоваться в качестве индикатора состояния окружающей среды

PARENTERAL VIRAL HEPATITISES IN THE IRKUTSK REGION

From all group of infectious pathology viral hepatitises, from which the most priority are the parenteral hepatitises B and С, are essential for health of mankind, also the Irkutsk region isn’t an exception. The aim of the study: to assess an epidemiological situation in sharp and chronic forms of the viral hepatitises B and С in the territory of the Irkutsk region for the long-term period. Materials and methods. The retrospective analysis of an epidemiological situation on viral hepatitises B and C in Russia, Siberian Federal District and in the Irkutsk region for 2008–2016 is carried out. Results. The expressed decrease in incidence of acute viral hepatitis B is noted, at a chronic form of this disease rates of decrease had less expressed character that can be connected with carrying out by mass vaccinal prevention. The carried-out ranged distribution of territories for all forms of viral hepatitis B and viral hepatitis C in the Irkutsk region has allowed to reveal territories of risk. Conclusion. Parenteral viral hepatitises (sharp and chronic forms) are widespread in the territory of the Irkutsk region. From 43 administrative territories of the area, 24 belong to unsuccessful on incidences from which five are to territories of high epidemiological risk: cities of Irkutsk, Angarsk and Ust-Ilimsk and also Katangsky and Shelekhovsky districts

Многоуровневые инъекции ботулинического токсина типа А (Абоботулотоксина) при лечении спастических форм детского церебрального паралича: ретроспективное исследование опыта 8 российских центров

Background: The contemporary application of Botulinum toxin A (BTA) in cerebral palsy (CP) implies multilevel injections both in on-label and off-label muscles. However, there is no single international opinion on the effective and safe dosages, target muscles, and intervals between the injections.Objective: Our aim was to analyze the Russian multicenter independent experience of single and repeated multilevel injections of Abobotulinum toxin А in patients with spastic forms of CP.Methods: 8 independent referral CP-centers (10 hospitals) in different regions of Russia. Authors evaluated intervals between the injections, dosages of the BTA for the whole procedure, for the body mass, for the each muscle, and functional segment of the extremities.Results: 1872 protocols of effective BTA injections (1–14 repeated injections) for 724 patients with spastic CP were included. The age of the patients was between 8 months to 17 years 4 months at the beginning of the treatment (with a mean of 3 years 10 months). Multilevel BTA injections were indicated for the majority (n = 634, 87.6%) of the patients in all the centers. The medians of the dosages for the first BTA injection were between 30–31 U/kg (500 U), the repeated injections doses up to 45 U/kg (1000 U) (in most centers). The median intervals between the repeated injections were 180–200 days in 484 (66.9%) patients and 140–180 days in 157 (24.7%) patients. In 2 centers, children with GMFCS IV–V were injected more often than others.Conclusion: Multilevel BTA injections were indicated for the most patients. The initial dose of Abobotulinum toxin A was 30–31 U/kg. The repeated injections dose could increase up to 40 U/kg. The repeated injections were done in 140–200 days after the previous injection.Современная концепция ботулинотерапии при детском церебральном параличе (ДЦП) предлагает использование многоуровневых инъекций в расширенное число мышц. Однако по-прежнему отсутствует консенсус относительно выбора оптимальных доз, мышц и интервалов между инъекциями.Цель исследования: изучить российский опыт применения однократных и повторных многоуровневых инъекций абоботулотоксина при лечении спастичности у пациентов с ДЦП.Методы: в ретроспективном исследовании проанализирован опыт ботулинотерапии при ДЦПв 8 специализированных центрах России. Изучали протоколы клинически эффективных инъекций. Оценивали общие дозы препарата БТА, дозы на единицу массы тела пациентов, на всю инъекционную сессию и отдельные мышцы, а также интервалы между инъекциями.Результаты: изучено 1872 протокола клинически эффективных инъекций, всего от 1 до 14 повторных инъекций, сделанных 724 пациентам в возрасте от 8 мес до 17 лет 4 мес (медиана возраста на момент первой инъекции БТА — 3 года 10 мес) на момент начала ботулинотерапии. Большинство пациентов (n = 634; 87,6% инъекций) получили многоуровневую ботулинотерапию. Во всех центрах при первичных инъекциях БТА медиана доз находилась в пределах 30–31 Ед/кг массы тела (общая — 500 Ед). При повторных инъекциях в большинстве учреждений максимальные дозы превышали 45 Ед/кг (1000 Ед). Средние интервалы между повторными инъекциями колебались в пределах 140–180 сут для 157 (24,7%) и 180–200 сут для 484 (66,9%) пациентов. В 2 из 8 центров пациенты с наиболее выраженными двигательными нарушениями (GMFCS IV–V) требовали более частых повторных инъекций БТА.Заключение: в специализированных центрах большинству пациентов с ДЦП ботулинотерапию проводили по многоуровневой схеме. Общая доза абоботулотоксина при первичных инъекциях составляла 30–31 Ед/кг; при повторных инъекциях она могла быть увеличена до 40 Ед/кг и более. Вопрос о повторном проведении инъекции БТА рассматривался в интервале 140–200 сут после предшествующей инъекции

Project of method developing of quality control of spruce essential oil by gas-liquid chromatography

Conditions of the chromatography analyses of essential oils providing the yield of all components with the contents over 0.01% were selected. Essential oils of 10 samples of Norway spruce growing in the same edaphic-climatic conditions of the park UE “Brovki” were obtained by hydrodistillation. Qualitative and quantitative analyses of the received essential oils were performed. More than 50 components composing the essential oil were identified. The obtained statistic data allowed to calculate standard deviation of repeatability, standard deviation of intermediate precision with a variable factor “time + operator”, expanded uncertainty of measurement results for the confidence level P = 0,95

Influence of the constituent composition on antimicrobial and perfume properties of fir essential oils

The essential oils of 7 kinds of spruces by the method of steam distillation were obtained. The qualitative and quantitative composition of the received essential oils was studied by gas-liquid chromatography. Antimicrobial activity of essential oils on substances Staphilococcus aureusATSS 6538 P, Pseudomonas aeruginosaATSS 9027, Bacillus subtilisATSS 6633, Candida albicansATSS 885-653 was defined. Perfume tasting evaluation of the essential oils was made

Evaluation of qualitative characteristics of essential oil of trees of the genus Abies and obtaining on their basis of perfumes

Detailed analysis of the resource base essential oils into the Republic of Belarus. It is shown that one of the sources of essential oils may be of wood greenery of coniferous breeds of trees. Essential oil from five kinds of the fir growing in id entical climatic and soil environments is received by the method of hy-drodistillation. Conditions of the chromatography analysis of essential oils providing an exit of all components with the contents over 0.01% are selected up. The qualitative and quantitative analysis of essential oils is carried out. In the structure of essential oils 55 components are identified. Based on the analysis of the quantitative content of components, recommendations on the use of essential oils of certain types of fir. The formulations of perfumes and samples of sh ampoo and hair balm based on essential oil-color fir (A. concolor ) and Siberian (A. sibirica). Tested indicators of quality and safety of the obtained samples. By all indicators the prototypes conform to the requirements of the standards. The experimental results obtained can be used for mass production of shampoo and hair bal

Elaboration of vegetable oils’ mixtures with a balanced fatty acid composition

Optimized mixtures of vegetable oils to ensure a balanced composition of ω-3 and ω-6 acids were developed. The analysis of the raw material base for oil industry of the Republic of Belarus were done. Oils of nine species were chosen for investigation, 5 of which are the traditional raw material for the production of vegetable oils, and 4 are alternative sources, the use of which is possible as enriching components of mixtures of vegetable oils. Imbalance of fatty acid composition of almost all vegetable oils was shown, which proves the need for development of oils mixtures. Different mixtures of vegetable oils that provide the necessary health ratio of polyunsaturated fatty acid were calculated by the method of linear programming formulations. GLC defined co-responsible resulting compositions blends calculated values. It was found that the proposal-conjugated ble nds No. 1 and No. 2 can be rec-ommended for daily and preventive feeding of population as PUFA ratio is 10 : 1, which fully meets the needs of the human body in the essential fatty acids. Sa mples No. 3 and No. 4 content the co-ratio of 5 : 1 because flaxseed oil rich in ω-3 fatty acids, which is sufficient for a recomme ndation of the prod-uct as a therapeutic feeding. The proposed blends of vegetable oils, are fully compliant with technical regulations on quality and safety of these products. In addition, the proposed mixtures of vegetable oils are undoubtedly due to the economic feasibility of the maximum using of the domestic raw canola, flax and blueberries, which fully corresponds to the direction of impor t substitution in the Republic of Belarus

Multilevel Botulinum Toxin A (Abobotulinum Toxin A) Injections in Spastic Forms of Cerebral Palsy: Retrospective Analysis of 8 Russian Centers Experience

Background: The contemporary application of Botulinum toxin A (BTA) in cerebral palsy (CP) implies multilevel injections both in on-label and off-label muscles. However, there is no single international opinion on the effective and safe dosages, target muscles, and intervals between the injections.Objective: Our aim was to analyze the Russian multicenter independent experience of single and repeated multilevel injections of Abobotulinum toxin А in patients with spastic forms of CP.Methods: 8 independent referral CP-centers (10 hospitals) in different regions of Russia. Authors evaluated intervals between the injections, dosages of the BTA for the whole procedure, for the body mass, for the each muscle, and functional segment of the extremities.Results: 1872 protocols of effective BTA injections (1–14 repeated injections) for 724 patients with spastic CP were included. The age of the patients was between 8 months to 17 years 4 months at the beginning of the treatment (with a mean of 3 years 10 months). Multilevel BTA injections were indicated for the majority (n = 634, 87.6%) of the patients in all the centers. The medians of the dosages for the first BTA injection were between 30–31 U/kg (500 U), the repeated injections doses up to 45 U/kg (1000 U) (in most centers). The median intervals between the repeated injections were 180–200 days in 484 (66.9%) patients and 140–180 days in 157 (24.7%) patients. In 2 centers, children with GMFCS IV–V were injected more often than others.Conclusion: Multilevel BTA injections were indicated for the most patients. The initial dose of Abobotulinum toxin A was 30–31 U/kg. The repeated injections dose could increase up to 40 U/kg. The repeated injections were done in 140–200 days after the previous injection