Pulmonary embolism and atrial fibrillation: analysis of data from the SIRENA Russian registry

Aim. To present the clinical characteristics and in-hospital prognosis in patients with pulmonary embolism (PE) and atrial fibrillation (AF).Material and methods. On the initiative of a working group of physicians, the basic principles of an observational prospective study (SIRENA registry) have been developed.Results. Among the 660 patients included in the registry, AF was diagnosed in almost every fourth patient — in 22,9% of cases (n=151), which reflects its high incidence in relation to PE. The prevalence of AF corresponded to such conditions as heart failure (HF) (23,2%; n=153), diabetes (15,6%; n=103), and hypertension (HTN) (65,7% n=400). The diagnosis of AF in most patients is based on the history data (n=144; 95,4%), while the first registered AF episode was verified in 7 patients (4,6%). Patients with AF were characterized by older age, significantly higher prevalence of HF (51,2%), HTN (80,8%), chronic kidney disease (18,5%), stroke or transient ischemic attack (23,2%). It is important to note the low prevalence of anticoagulant therapy (15,3%) in the group of patients with previously diagnosed AF (n=144). The prevalence of thrombolytic therapy in patients with AF was significantly lower than among patients without AF (13,9 vs 25,8% (p=0,026)), which is due to contraindications and underdiagnosis of PE. Given the predominantly senile age, high comorbidity rate in patients with AF, as well as the absence of outpatient anticoagulant therapy, in-hospital mortality in patients with PE and AF was 31,1%, and significantly differed from that in those without AF 12,6% (p=0,001). In the general group, post-mortem diagnosis of PE was noted in 7,7% of cases (n=51), of which the proportion of patients with AF was 54,9% (n=28). A possible explanation for the underestimation of PE in AF patients was an erroneous explanation of its manifestations (tachypnea, tachycardia, lower limb edema) due to concomitant HF.Conclusion. Suspicion for PE in elderly patients with AF and manifestations of HF decompensation, as well as the timely administration of anticoagulant therapy, will prevent both arterial and venous embolism

Phase Behavior of Aqueous Na-K-Mg-Ca-CI-NO3 Mixtures: Isopiestic Measurements and Thermodynamic Modeling

A comprehensive model has been established for calculating thermodynamic properties of multicomponent aqueous systems containing the Na{sup +}, K{sup +}, Mg{sup 2+}, Ca{sup 2+}, Cl{sup -}, and NO{sub 3}{sup -} ions. The thermodynamic framework is based on a previously developed model for mixed-solvent electrolyte solutions. The framework has been designed to reproduce the properties of salt solutions at temperatures ranging from the freezing point to 300 C and concentrations ranging from infinite dilution to the fused salt limit. The model has been parameterized using a combination of an extensive literature database and new isopiestic measurements for thirteen salt mixtures at 140 C. The measurements have been performed using Oak Ridge National Laboratory's (ORNL) previously designed gravimetric isopiestic apparatus, which makes it possible to detect solid phase precipitation. Water activities are reported for mixtures with a fixed ratio of salts as a function of the total apparent salt mole fraction. The isopiestic measurements reported here simultaneously reflect two fundamental properties of the system, i.e., the activity of water as a function of solution concentration and the occurrence of solid-liquid transitions. The thermodynamic model accurately reproduces the new isopiestic data as well as literature data for binary, ternary and higher-order subsystems. Because of its high accuracy in calculating vapor-liquid and solid-liquid equilibria, the model is suitable for studying deliquescence behavior of multicomponent salt systems

Ensuring the level of interaction of stakeholders of construction enterprises with financial and economic security

The tailing dump operation periodically leads to the failurThe article proves that modern economic conditions, which are characterized by instability of the socio-economic state, require improved approaches to the management of construction enterprises. The value of the factors, which determine the functioning of construction enterprises is increasing. The problem of ensuring financial and economic security in the system of interaction with stakeholders characterizes the modern aspects of their development. The importance of directions and peculiarities of stakeholder activity for the development of enterprises is determined. As a result of systematization of theoretical provisions, legal support and revealed features of functioning of construction enterprises, the types of stakeholders and indicators of the level of their interaction are determined. The ambiguity of changes in the formation and use of equity, cash and fulfillment of contractual obligations has been established. There is growth and focus on the quality of their implementation. The level of interaction of the studied construction enterprises with various groups of stakeholders is determined by the focus of considerable attention on ensuring relationships with customers. The measures affecting corporate relations to ensure financial and economic security of construction enterprises in the context of increasing the effectiveness of interaction with stakeholders are proposed

Influence of ratio of silicon complex and coagulant on silicon dioxide physicochemical characteristics

It is known that the physicochemical characteristics of amorphous SiO2 are influenced by the raw material, process temperature, pH of the reaction medium, the ratio of reagents, the addition of coagulant, and modes of washing and drying. Previously, a waste-free technology for the production of biogenic silicon dioxide was described. However, there was a question of the ability to control the grain size of the final product. Therefore, the aim of our work was to study the effect of the ratio of mass concentrations of silicon-containing solution and coagulant (5:100; 5:500; 5:1000) on the physicochemical properties of the final product. The obtained samples of silicon dioxide were studied by various physicochemical methods. XRD pattern of the obtained silica showed that the 2-theta region between 5° and 80° at long collection times indicates no crystalline peaks. The FT-IR spectrum of the whole silica samples shows typical functional groups corresponding to pure silicon dioxide at 1074, 982, 800, and 457 cm?1. There are two distinct mass loss steps in thermograms (TGA). It was established that obtained samples had a specific surface area of 86.8, 318.3, and 310.2 m2/g and pore size of 3.3, 13.8, and 9.2 nm depending on coagulant concentration (100, 500, and 1000), respectively. The atomic force microscope method established that the 3D image clearly shows the pointed vertices of SiO2 tetrahedral for the whole gels and some powders depending on the ratio of silicon-containing solution and coagulant (5:100; 5:500; 5:1000). © 2023, King Abdulaziz City for Science and Technology

Імунотропна активність препарату «фурамаг» у процесі терапії повторних епізодів інфекції урогенітального тракту у дітей

The aim: to increase the therapy effectiveness for recurrent urogenital tract infection in children through the use of the Furamag immunotropic properties.Materials and methods. Under observation were 60 children aged 2 to 6 years in the period of exacerbation of recurrent urogenital tract infections. Two observation groups of 30 children each were formed. Children of the 1st group received Furamag for 7 days; group 2 children received cefixime also for 7 days.Results. The immunotropic activity of Furamag was manifested by a decrease in the number of children with low indicators: phagocytic index and number, phagocytosis completion index, spontaneous NST-test index, stimulated with staphylococcus NST-test and its index, natural killer CD3-CD16+CD56+, low neutrophil myeloperoxidase activity, decreased serum IgG and IgA, urine secretory sIgA.Conclusion. The dynamics of the innate and acquired immunity indicators showed the immunotropic activity of the 7-day of Furamag use, which improves the effectiveness of the treatment of recurrent urogenital tract infection in children.The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee (LEC) of a participating institution. The informed consent of the patient was obtained for conducting the studies.Цель: повышение эффективности терапии повторных эпизодов инфекции урогенитального тракта у детей за счет использования иммунотропных свойств препарата «Фурамаг».Материалы и методы. Под наблюдением находились 60 детей в возрасте от 2 до 6 лет в периоде обострения рекуррентных инфекций урогенитального тракта. Сформированы две группы наблюдения по 30 детей в каждой. Дети первой группы получали Фурамаг на протяжении 7 дней; дети 2-й группы получали цефиксим на протяжении 7 дней.Результаты. Иммунотропная активность Фурамага проявилась уменьшением количества детей с низкими показателями: фагоцитарного индекса и числа, индекса завершенности фагоцитоза, индекса спонтанного НСТ-теста, стимулированного стафилококком НСТ-теста и его индекса, натуральных киллеров CD3>CD16+CD56+, низкой активностью миелопероксидазы нейтрофилов, пониженным сывороточным содержанием IgG и IgA, секреторного sIgA в моче.Выводы. Динамика показателей врожденного и приобретенного иммунитета показала иммунотропную активность 7-дневного применения Фурамага, что улучшает эффективность терапии повторных эпизодов инфекции урогенитального тракта у детей.Исследование было выполнено в соответствии с принципами Хельсинской Декларации. Протокол исследования был одобрен Локальным этическим комитетом (ЛЭК) учреждения. На проведение исследований было получено информированное согласие родителей детей (или их опекунов).Мета: підвищення ефективності терапії повторних епізодів інфекції урогенітального тракту у дітей за рахунок використання імунотропних властивостей препарату «Фурамаг».Матеріали і методи. Під спостереженням знаходилися 60 дітей віком від 2 до 6 років у періоді загострення рекурентних інфекцій урогенітального тракту. Сформовано дві групи спостереження по 30 дітей у кожній. Діти першої групи отримували Фурамаг протягом 7 днів; діти другої групи отримували цефіксим протягом 7 днів.Результати. Імунотропна активність Фурамагу проявилася зменшенням кількості дітей з низькими показниками: фагоцитарного індексу і числа, індексу завершеності фагоцитозу, індексу спонтанного НСТ-тесту, стимульованого стафілококом НСТ-тесту і його індексу, натуральних кілерів CD3-CD16+CD56+, низькою активністю мієлопероксидази нейтрофілів, зниженим сироватковим вмістом IgG і IgA, секреторного sIgA у сечі.Висновки. Динаміка показників вродженого і набутого імунітету показала імунотропну активність 7-денного застосування Фурамагу, що покращує ефективність терапії повторних епізодів інфекції урогенітального тракту у дітей.Дослідження виконані відповідно до принципів Гельсінської Декларації. Протокол дослідження ухвалений Локальним етичним комітетом (ЛЕК) установи. На проведення досліджень було отримано поінформовану згоду батьків дітей (або їхніх опікунів)