Mathematical model of diagnostics of perinatal damage of the central nervous system in infants in the neonatal period

Questions of relevance and timeliness of diagnostics of perinatal disturbances of the central nervous system in newborns are considered in the article. Research objective was to determine the reliable recognition of the development of newborn encephalopathy at the age of the first two weeks of life according to neurological examination and neurosonography parameters with Doppler study of cerebral vessels. Features of the neurology status and data of ultrasonic examination of brain with Doppler study of cerebral vessels in 58 newborns with pathology of the nervous system and 23 healthy newborns are investigated. 10 sings of the neurological status and 10 parameters of ultrasonic examination are analyzed. By results of the obtained findings, prognostic rule is developed, governed by application of discriminant analysis of the studied signs, allowing to diagnose encephalopathy in newborn with sensitivity and specificity of 95% in the first week of life. Its application promotes timely identification and the beginning of therapy at infants from risk group of development of severe neurological dysfunction and preventing the growth of disability among infants. © 2017 Team of Authors

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

The paper discusses the results of a research on physicochemical and biochemical properties of the Keplerate-type molybdenum-based nanocluster polyoxometalates (POMs), which show promise in the field of biomedicine as a means of targeted drug delivery, including the transport to immune privileged organs. POMs can be considered as components of releasing systems, including the long-acting ones with feedback (for controlling the drug active component release rate). POMs are promising drugs for the treatment of anemia. Also, the paper deals with the results of studies of POM effect on living systems at the molecular and cellular levels, at that of individual organs, and on the organism as a whole. The mechanism and kinetics of POM destruction and possibilities of stabilization, the oscillatory phenomena manifestation, the formation of POM conjugates with bioactive substances which can be released during the destruction of POM, with polymer components, and with indicator fluorescent dyes, as well as forecasts for further research, are considered. © 2021, ITMO University. All rights reserved.The paper was prepared in the framework of implementation of the State Assignment from the Ministry of Education and Science of the Russian Federation (Projects Nos. AAAA-A20-120061990010-7 (FEUZ-2020-0052) and AAAA-A18-118020590107-0), as well as of the Program for Increasing Competitiveness of UrFU (financially supported according to the Decree No. 211 of the Government of the Russian Federation, Contract No. 02.A03.21.0006). The research aimed at creating the long-time drug release systems with feedback was carried out within the framework of the project of the Russian Science Foundation No. 19-73-00177

MATHEMATICAL MODEL OF DIAGNOSTICS OF PERINATAL DAMAGE OF THE CENTRAL NERVOUS SYSTEM IN INFANTS IN THE NEONATAL PERIOD

Questions of relevance and timeliness of diagnostics of perinatal disturbances of the central nervous system in newborns are considered in the article. Research objective was to determine the reliable recognition of the development of newborn encephalopathy at the age of the first two weeks of life according to neurological examination and neurosonography parameters with Doppler study of cerebral vessels. Features of the neurology status and data of ultrasonic examination of brain with Doppler study of cerebral vessels in 58 newborns with pathology of the nervous system and 23 healthy newborns are investigated. 10 sings of the neurological status and 10 parameters of ultrasonic examination are analyzed. By results of the obtained findings, prognostic rule is developed, governed by application of discriminant analysis of the studied signs, allowing to diagnose encephalopathy in newborn with sensitivity and specificity of 95% in the first week of life. Its application promotes timely identification and the beginning of therapy at infants from risk group of development of severe neurological dysfunction and preventing the growth of disability among infants

Synthesis, morphology, and activity of La1-xAgxMnO3 +/- y catalysts

La1-xAgxMnO3 +/- y (x = 0-0.3) mixed oxides have been synthesized by the pyrolysis of polymer-salt compositions using different organic compounds and different salt: organic compound ratios. The correlation between the reaction medium temperature during pyrolysis, the composition of the resulting oxide, and synthesis conditions has been investigated. The effect of these conditions on the character of the pyrolysis process, on the phase composition and microstructure of the resulting oxide particles and metallic silver, and on their mutual distribution is reported. The catalytic properties of the synthesized oxides in methane and soot oxidation are considered, and a correlation is established between the catalytic activity of the oxides and the synthesis conditions

MULTI-CHANNEL VOLUME SPHYGMOGRAPHY IN CARDIOANGIOLOGICAL SCREENING OF THE ADULT POPULATION

Aim. To study the possibilities of using multi-channel volume sphygmography (MCVS) in prophylactic medical examination of the population.Material and methods. Simultaneous examination of 522 individuals older than 18 years was performed. Along with standard procedures provided by the prophylactic medical examination program synchronous registration of blood pressure (BP) on four extremities by MCVS was performed. At that a difference in systolic BP between arms (ΔSBParm) and legs (ΔSBPleg) and ankle-brachial index (ABI) were automatically calculated. Values of │ΔSBParm│ or │ΔSBPleg│≥15 mm Hg or ABI≤0.9 were considered as markers of atherosclerotic vascular disease.Results. Signs of peripheral arterial atherosclerotic lesions among patients ≥40 years old were found in 14.7% of the cases (95% confidence interval [CI] 11.7-18.4). Relative risks of atherosclerotic lesions in arteries increase 1.71-fold (95% CI 1.06-2.74) in arterial hypertension, 1.70-fold (95% CI 1.08-2.68) – in obesity, 1.91 fold (95% CI 1.17-3.12) – in diabetes, as well as with the increasing levels of cardiovascular risk. In patients with ischemic heart disease and a history of cerebral stroke MCVS can detect signs of multifocal atherosclerosis in 21% (95% CI 14-32) and 22% (95% CI 9-46) of the cases, respectively.Conclusion. MCVS with the determination of ΔSBParm, ΔSBPleg and ABI may be regarded as the basis for low-cost and efficient system of cardioangiological screening.</p

PROCESS OF MANUFACTURE OF FILM ON BASE OF COMPLEX OXIDES

FIELD: integral and magnetooptics, laser and SHF technologies. SUBSTANCE: working solution containing following components, per cent by mass: salts of metal components in terms of metals 0.1-5.0; polyvinyl alcohol 5.0-20.0; polyvinylpyrrolidon 1.0- 20.0; water being the balance. Before application of solution substrate is treated in 5-30% aqueous solution of ammonia at 60-100 C for the course of 10- 60 min. Then it is rinsed for 5-15 min in water and is dried to complete removal of moisture at 20-40 C. Working solution is applied to treated surface layer by layer with intermediate drying of each layer at room temperature and with heating of at least two layers till organic component is removed. Final firing is conducted at 600-960 C. Injection of polyvinylpyrrolidon increases adhesion of films to substrate and suppresses crystallization of salts thanks to complex formation. Treatment of substrates in ammonia gives additional adhesion of films owing to adsorption of hydrooxile groups on surface of substrate. EFFECT: facilitated manufacture. 1 tbl.Использование: в каталитической, сверхпроводящей, лазерной, СВЧ-технике, магнитооптике, интегральной оптике. Сущность изобретения: готовят рабочий растовор, содержащий следующие компоненты, мас. соли металлических компонентов в пересчете на металлы 0,1 5; поливиниловый спирт 5 20; поливинилпирролидон 1 20; вода остальное. Перед нанесением рабочего раствора обрабатывают подложку в 5 30%-ном водном растворе аммиака при 60 100°С в течение 10 60 мин. Затем ее промывают 5 - 15 мин в воде и сушат до полного удаления влаги при 20 40°С. Рабочий раствор наносят на обработанную подложку послойно с промежуточной сушкой каждого слоя при комнатной температуре и нагревом не менее двух слоев до удаления органической компоненты. Окончательный отжиг проводят при 600 960°С. Введение поливинилпирролидона повышает адгезию пленок к подложке и подавляет кристаллизацию солей за счет комплексообразования, что повышает химическую однородность пленок. Обработка подложек в аммиаке дает дополнительное увеличение адгезии пленок за счет адсорбции на поверхности подложек гидроксильных групп. 1 табл