Responses of women to orthostatic and exercise stresses

The results are presented from a special physiological study of women at the Johnson Space Center in 1976 to 1977. Its purpose was to establish a large (98 subjects) database from normal working women. The data sets are medical historical, clinical, anthropometric, and stress response statistics useful for establishing medical criteria for selecting women astronauts. Stressors were lower body negative pressure and static standing (both orthostatic) and treadmill exercise (ergometric). Data shown are original individual values with analyses and subsets, and statistical summaries and correlations relating to human responses to microgravity. Similarities appear between the characteristics of women in this study and those of women astronauts currently flying in Shuttle crews

Design features of the solenoid magnets for the central cell of the MFTF-B

The 14 superconducting solenoid magnets which form the central cell of the MFTF-B are being designed and fabricated by General Dynamics for the Lawrence Livermore National Laboratory. Each solenoid coil has a mean diameter of five meters and contains 600 turns of a proven conductor type. Structural loading resulting from credible fault events, cooldown and warmup requirements, and manufacturing processes consistent with other MFTF-B magnets have been considered in the selection of 304 LN as the structural material for the magnet. The solenoid magnets are connected by 24 intercoil beams and 20 solid struts which resist the longitudinal seismic and electromagnetic attractive forces and by 24 hanger/side supports which react magnet dead weight and seismic loads. A modular arrangement of two solenoid coils within a vacuum vessel segment allow for sequential checkout and installation

Design features of the A-cell and transition coils of MFTF-B

The MFTF-B transition coil and A-cell magnet designs use variations of the copper-stabilized NbTi conductor developed by LLNL for the MFTF Yin-Yang magnets. This conductor will be wound on the one inch thick (12.7 mm) stainless steel coil forms using a two-axis winding machine similar to the existing LLNL Yin-Yang winding machine. After winding, covers will be placed over the coil and welded to the coil form to form a helium-tight jacket around the conductor. These jacketed coils are then enclosed in thick structural cases that react the large Lorentz forces on the magnets. The space between the coil jacket and case will be filled by a stainless steel bladder that will be injected with urethane. The injection bladder will provide cooling passages during cooldown as well as transmitting the Lorentz forces between the jacket and the case. The large self-equilibrating lobe-spreading forces on the magnets (29.10/sup 6/ lb, 127.0 MN) for the A-cell are reacted primarily through the thick 304 LN case into the external superstructure. The net Lorentz forces and the inertial forces on the magnet are reacted through support systems into the LLNL vacuum vessel structure

Activation of Central Melanocortin Pathways by Fenfluramlne

D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective weight loss drugs, but was withdrawn from clinical use because of reports of cardiac complications in a subset of patients. Discerning the neurobiology underlying the anorexic action of d-FEN may facilitate the development of new drugs to prevent and treat obesity. Through a combination of functional neuroanatomy, feeding, and electrophysiology studies in rodents, we show that d-FEN-induced anorexia requires activation of central nervous system melanocortin pathways. These results provide a mechanistic explanation of d-FEN\u27s anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective antiobesity treatments

Melanocortin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [36]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous antagonists include agouti and agouti-related protein. ACTH(1-24) was approved by the US FDA as a diagnostic agent for adrenal function test, whilst NDP-MSH was approved by EMA for the treatment of erythropoietic protoporphyria. Several synthetic melanocortin receptor agonists are under clinical development

Melanocortin receptors in GtoPdb v.2023.1

Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [41]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous antagonists include agouti and agouti-related protein. ACTH(1-24) was approved by the US FDA as a diagnostic agent for adrenal function test. setmelanotide was approved by the US FDA for weight management in patients with POMC, PCSK1 or LEPR defiency, bremelanotide was approved by the US FDA for generalized hypoactive sexual desire disorder in premenopausal women, and NDP-MSH (afamelanotide) was approved by the EMA for the treatment of erythropoietic protoporphyria. Several synthetic melanocortin receptor agonists are under clinical development

Melanocortin receptors in GtoPdb v.2021.3

Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [41]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous antagonists include agouti and agouti-related protein. ACTH(1-24) was approved by the US FDA as a diagnostic agent for adrenal function test, whilst NDP-MSH was approved by EMA for the treatment of erythropoietic protoporphyria. Several synthetic melanocortin receptor agonists are under clinical development

Mirror fusion test facility magnet system. Final design report

Information is given on each of the following topics: (1) magnet description, (2) superconducting manufacture, (3) mechanical behavior of conductor winding, (4) coil winding, (5) thermal analysis, (6) cryogenic system, (7) power supply system, (8) structural analysis, (9) structural finite element analysis refinement, (10) structural case fault analysis, and (11) structural metallurgy. (MOW