148 research outputs found
Radiative Decay of Vector Quarkonium: Constraints on Glueballs and Light Gluinos
Given a resonance of known mass, width, and J^{PC}, we can determine its
gluonic branching fraction, b(R->gg), from data on its production in radiative
vector quarkonium decay, V -> gamma+R. For most resonances b(R->gg) is found to
be O(10%), consistent with being q-qbar states, but we find that both
pseudoscalars observed in the 1440 MeV region have b(R->gg) ~ 1/2 - 1, and
b(f_0^{++}->gg) ~ 1/2. As data improves, b(R->gg) should be a useful
discriminator between q-qbar and gluonic states and may permit quantitative
determination of the extent to which a particular resonance is a mixture of
glueball and q-qbar. We also examine the regime of validity of pQCD for
predicting the rate of V -> gamma+eta_gluino, the ``extra'' pseudoscalar bound
state which would exist if there were light gluinos. From the CUSB limit on
peaks in Upsilon -> gamma X, the mass range 3 GeV < m(eta_gluino) < 7 GeV can
be excluded. An experiment must be significantly more sensitive to exclude an
eta_gluino lighter than this.Comment: 36pp (inc figs),RU-94-04. (Replaces original which didn't latex
correctly and didn't have figures.
Testing Scalar-Tensor Gravity Using Space Gravitational-Wave Interferometers
We calculate the bounds which could be placed on scalar-tensor theories of
gravity of the Jordan, Fierz, Brans and Dicke type by measurements of
gravitational waveforms from neutron stars (NS) spiralling into massive black
holes (MBH) using LISA, the proposed space laser interferometric observatory.
Such observations may yield significantly more stringent bounds on the
Brans-Dicke coupling parameter \omega than are achievable from solar system or
binary pulsar measurements. For NS-MBH inspirals, dipole gravitational
radiation modifies the inspiral and generates an additional contribution to the
phase evolution of the emitted gravitational waveform. Bounds on \omega can
therefore be found by using the technique of matched filtering. We compute the
Fisher information matrix for a waveform accurate to second post-Newtonian
order, including the effect of dipole radiation, filtered using a currently
modeled noise curve for LISA, and determine the bounds on \omega for several
different NS-MBH canonical systems. For example, observations of a 1.4 solar
mass NS inspiralling to a 1000 solar mass MBH with a signal-to-noise ratio of
10 could yield a bound of \omega > 240,000, substantially greater than the
current experimental bound of \omega > 3000.Comment: 18 pages, 4 figures, 1 table; to be submitted to Phys. Rev.
Kinematic Effects in Radiative Quarkonia Decays
Non-relativistic QCD (NRQCD) predicts colour octet contributions to be
significant not only in many production processes of heavy quarkonia but also
in their radiative decays. We investigate the photon energy distributions in
these processes in the endpoint region. There the velocity expansion of NRQCD
breaks down which requires a resummation of an infinite class of colour octet
operators to so-called shape functions. We model these non-perturbative
functions by the emission of a soft gluon cluster in the initial state. We
found that the spectrum in the endpoint region is poorly understood if the
values for the colour octet matrix elements are taken as large as indicated
from NRQCD scaling rules. Therefore the endpoint region should not be taken
into account for a fit of the strong coupling constant at the scale of the
heavy quark mass.Comment: LaTeX, 17 pages, 5 figures. The complete paper is also available via
the www at http://www-ttp.physik.uni-karlsruhe.de/Preprints
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease
Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer’s disease (AD), but little is known about the molecular mechanisms underlying this regional vulnerability. Here we utilize the 10 × Visium platform to define the spatial transcriptomic profile in both AD and control (CT) MTG. We identify unique marker genes for cortical layers and the white matter, and layer-specific differentially expressed genes (DEGs) in human AD compared to CT. Deconvolution of the Visium spots showcases the significant difference in particular cell types among cortical layers and the white matter. Gene co-expression analyses reveal eight gene modules, four of which have significantly altered co-expression patterns in the presence of AD pathology. The co-expression patterns of hub genes and enriched pathways in the presence of AD pathology indicate an important role of cell–cell-communications among microglia, oligodendrocytes, astrocytes, and neurons, which may contribute to the cellular and regional vulnerability in early AD. Using single-molecule fluorescent in situ hybridization, we validated the cell-type-specific expression of three novel DEGs (e.g., KIF5A, PAQR6, and SLC1A3) and eleven previously reported DEGs associated with AD pathology (i.e., amyloid beta plaques and intraneuronal neurofibrillary tangles or neuropil threads) at the single cell level. Our results may contribute to the understanding of the complex architecture and neuronal and glial response to AD pathology of this vulnerable brain region
Self-administered gerocognitive examination (SAGE) aids early detection of cognitive impairment at primary care provider visits
IntroductionCurrent estimates indicate that up to 50–75% of dementia cases are undiagnosed at an early stage when treatments are most effective. Conducting robust accurate cognitive assessments can be time-consuming for providers and difficult to incorporate into a time-limited Primary Care Provider (PCP) visit. We wanted to compare PCP visits with and without using the self-administered SAGE to determine differences in identification rates of new cognitive disorders.MethodsThree hundred patients aged 65–89 without diagnosed cognitive disorders completing a non-acute office visit were enrolled (ClinicalTrials.gov identifier: NCT04063371). Two PCP offices conducted routine visits for 100 consecutive eligible patients each. One office used the SAGE in an additional 100 subjects and asked available informants about cognitive changes over the previous year. Chart reviews were conducted 60 days later. One-way analysis of variance and Fisher exact tests were used to compare the groups and outcomes.ResultsWhen SAGE was utilized, the PCP documented the detection of new cognitive conditions/concerns six times (9% versus 1.5%) as often (p = 0.003). The detection rate was nearly 4-fold for those with cognitively impaired SAGE scores (p = 0.034). Patients having impaired SAGE score and informant concerns were 15-fold as likely to have new cognitive conditions/concerns documented (p = 0.0007). Among providers using SAGE, 86% would recommend SAGE to colleagues.DiscussionSAGE was easily incorporated into PCP visits and significantly increased identification of new cognitive conditions/concerns leading to new diagnoses, treatment, or management changes. The detection rate increased 15-fold for those with impaired SAGE scores combined with informant reports
Varying Alpha in a More Realistic Universe
We study the space-time evolution of the fine structure constant, ,
inside evolving spherical overdensities in a lambda-CDM Friedmann universe
using the spherical infall model. We show that its value inside virialised
regions will be significantly larger than in the low-density background
universe. The consideration of the inhomogeneous evolution of the universe is
therefore essential for a correct comparison of extragalactic and solar system
limits on, and observations of, possible time variation in and other
constants. Time variation in in the cosmological background can give
rise to no locally observable variations inside virialised overdensities like
the one in which we live, explaining the discrepancy between astrophysical and
geochemical observations.Comment: 5 pages, 5 figures. An extra section added describing the spherical
collapse model. References added. Accepted for publication in Phys. Lett.
Radiative Decays of the Upsilon(1S) to a Pair of Charged Hadrons
Using data obtained with the CLEO~III detector, running at the Cornell
Electron Storage Ring (CESR), we report on a new study of exclusive radiative
Upsilon(1S) decays into the final states gamma pi^+ pi^-, gamma K^+ K^-, and
gamma p pbar.. We present branching ratio measurements for the decay modes
Upsilon(1S) to gamma f_2(1270), Upsilon(1S) to gamma f_2'(1525), and
Upsilon(1S) to gamma K^+K^-; helicity production ratios for f_2(1270) and
f_2'(1525); upper limits for the decay Upsilon(1S) to gamma f_J(2200), with
f_J(2220) to pi^+ pi^-, K^+ K^-, p pbar; and an upper limit for the decay
Upsilon(1S) to gamma X(1860), with X(1860) to gamma p pbar.Comment: 17 pages postscript,also available through
http://www.lns.cornell.edu/public/CLNS/2005/, Submitted to PR
Observation of Pseudoscalar and Axial Vector Resonances in pi- p -> K+ K- pi0 n at 18 GeV
A new measurement of the reaction pi- p -> K+ K- pi0 n has been made at a
beam energy of 18 GeV. A partial wave analysis of the K+ K- pi0 system shows
evidence for three pseudoscalar resonances, eta(1295), eta(1416), and
eta(1485), as well as two axial vectors, f1(1285), and f1(1420). Their observed
masses, widths and decay properties are reported. No signal was observed for
C(1480), an IG J{PC} = 1+ 1{--} state previously reported in phi pi0 decay.Comment: 7 pages, 6 figs, to be submitted to Phys. Let
A Phenomenological Analysis of Gluon Mass Effects in Inclusive Radiative Decays of the and $\Upsilon
The shapes of the inclusive photon spectra in the processes \Jp \to \gamma
X and \Up \to \gamma X have been analysed using all available experimental
data.
Relativistic, higher order QCD and gluon mass corrections were taken into
account in the fitted functions. Only on including the gluon mass corrections,
were consistent and acceptable fits obtained. Values of
GeV and GeV were found for the
effective gluon masses (corresponding to Born level diagrams) for the \Jp and
\Up respectively. The width ratios \Gamma(V \to {\rm hadrons})/\Gamma(V \to
\gamma+ {\rm hadrons}) V=\Jp, \Up were used to determine and . Values consistent with the current world
average were obtained only when gluon mass correction factors,
calculated using the fitted values of the effective gluon mass, were applied. A
gluon mass GeV, as suggested with these results, is consistent with
previous analytical theoretical calculations and independent phenomenological
estimates, as well as with a recent, more accurate, lattice calculation of the
gluon propagator in the infra-red region.Comment: 50 pages, 11 figures, 15 table
The integration of occlusion and disparity information for judging depth in autism spectrum disorder
In autism spectrum disorder (ASD), atypical integration of visual depth cues may be due to flattened perceptual priors or selective fusion. The current study attempts to disentangle these explanations by psychophysically assessing within-modality integration of ordinal (occlusion) and metric (disparity) depth cues while accounting for sensitivity to stereoscopic information. Participants included 22 individuals with ASD and 23 typically developing matched controls. Although adults with ASD were found to have significantly poorer stereoacuity, they were still able to automatically integrate conflicting depth cues, lending support to the idea that priors are intact in ASD. However, dissimilarities in response speed variability between the ASD and TD groups suggests that there may be differences in the perceptual decision-making aspect of the task
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