The wall flora of the Nebet Tepe Architectural Reserve in the city of Plovdiv (Bulgaria)

The flora of the Nebet Tepe Architectural Reserve in the city of Plovdiv (Thracian Plain) was studied in the period 1998–2003. The number of plants growing spontaneously on and around the fragments of the fortification wall and on the pavements is 131. The flora is analyzed with respect to the local distribution of the taxa, their chorology, life form and geoelement characteristics. The flora contains a relatively high proportion of ruderals and weeds. The hemicryptophytes and therophytes constitute the largest group. The following families are distinguished by the greatest number of species: Asteraceae (14), Fabaceae (13), Poaceae (12), Brassicaceae (8), Scrophulariaceae (7), Caryophyllaceae (7). The species Cerastium tauricum Spreng. and Melica transsilvanica Schur are recorded for the first time for the flora of the Thracian Plain floristic region. The results are compared with other European and Mediterranean wall floras

The wall flora of the Nebet Tepe Architectural Reserve in the city of Plovdiv (Bulgaria)

The flora of the Nebet Tepe Architectural Reserve in the city of Plovdiv (Thracian Plain) was studied in the period 1998–2003. The number of plants growing spontaneously on and around the fragments of the fortification wall and on the pavements is 131. The flora is analyzed with respect to the local distribution of the taxa, their chorology, life form and geoelement characteristics. The flora contains a relatively high proportion of ruderals and weeds. The hemicryptophytes and therophytes constitute the largest group. The following families are distinguished by the greatest number of species: Asteraceae (14), Fabaceae (13), Poaceae (12), Brassicaceae (8), Scrophulariaceae (7), Caryophyllaceae (7). The species Cerastium tauricum Spreng. and Melica transsilvanica Schur are recorded for the first time for the flora of the Thracian Plain floristic region. The results are compared with other European and Mediterranean wall floras

Agitation Effects and Kinetic Constants of Exoglucomannan Production by Antarctic Yeast Strain in a Stirred Tank Bioreactor

Exoglucomannan production by Antarctic yeast Sporobolomyces salmonicolor AL1 is studied at semi-tech scale in a 5 L stirred tank bioreactor and the bioreaction kinetics is quantified. The organism’s unconventional response to agitation is analyzed in terms of the agitation-induced mechanical stress. The yeast maximum production activity was observed at agitation rate 400 rpm and conserved or decreased at further increase in mixing intensity. Referring to the relationship of cell growth and aeration intensity, the various production activity, oxygen availability and cell growth are considered as a starting point to elucidate the possible reasons for the anomaly. At suspicion of shear detrimental effect on the yeast cells, the hydrodynamic stress acting on cell particles is determined and the microorganism morphology at low and high mixing intensity is examined. Biological stability is registered and the agitation effect is attributed to depressed metabolic activity at the evolving dissolved oxygen tension rather than to direct effect of hydrodynamics. A kinetic model is proposed. The specific growth rate (µ, h–1) and growth-associated (g EPS g–1 cells), and non-growth associated (g EPS g–1 cells h–1) production constants are determined and compared with reported estimates for similar reference EPS fermentations. The model and its parameters are determined in well-mixed cultures and could be upgraded further to account for mixing non-ideality and mass transfer in larger vessels

Variability of Semantic Structure of Oral Spontaneous Monologues “About Myself” depending on “Gender” Factor

The influence of the social factor “gender of speakers” on the semantic structure of spontaneous monological texts generated by them is considered. A review of sociolinguistic studies on the influence of this social factor on the processes of text formation is made. The conclusion is made about the expediency of applying the methods of sociolinguistics and cognitive linguistics in the study of the problem of gender conditionality of the generation of oral spontaneous texts. The authors highlight the existing linguistics views on the text and its structure. A new understanding of semantic structure of a text is proposed as a set of semantic components of a text at different levels (micro-topics of a text and lexical units, semantics of which implements these micro-topics), and the hierarchical system of various relations (semantic and grammatical) between lexical units and micro-topics forming a unity deep and surface structures of the text. The author’s method of semantic analysis of the linked text fields is used, based on the method of graphosemantic modelling implemented in the IS “Semograph.” The material of the study was 48 oral spontaneous monologues “About myself,” the sample is balanced in terms of “gender,” “age” and “education.” Particular attention is paid to the analysis of the influence of the factor “gender” on the variability of the semantic structure of the oral spontaneous monologues “About myself,” which interacts with other social parameters of speakers (age and education)

The financial market instruments for risk management in the commodities secto

© Medwell Journals, 2017. Financial risk is caused by changes in commodity prices that affect the cash flows and market value of a company and therefore, its financial health and competitive position in product and labor markets. In the study the analysis was performed determining the risk of changing commodity prices. Reviewed risk management strategy changes in commodity prices. The study was proposed and discussed financial market instruments for risk management in the commodities sector. These tools include: forwards, options and swaps. The researchers conducted an analysis of the proposed financial instruments revealed their advantages and disadvantages

Personalized targeted therapy of moderate and severe atopic asthma in Russia

Introduction. Taking into account the prevalence of asthma and especially severe atopic asthma which requires carefully selected and expensive therapy, the appearance of the domestic biosimilar omalizumab among biological therapy drugs makes the choice of treatment for this category more affordable. The article presents the results of an observational open prospective clinical trial of the omalizumab biosimilar in severe athopic asthma patients.The purpose of this study was to evaluate the efficacy and safety of the domestic production biosimilar in the real clinical practice.Materials and methods. The study involved 10 adult patients aged 19 to 55 years with a diagnosis of moderate to severe uncontrolled persistent asthma treated with mediun to high dose ICS and second&more controller (ACQ-5 ≥ 1,5, FEV1 < 80% of the predicted normal value). For 26 weeks all patients received the omalizumab. The evaluation of the efficacy was provided taking into account asthma symptoms improvement the results of ACQ-5, FEV1, PEF, asthma exacerbations and the use of health resources. Results. According to the results of data analysis due to omalizumab all patients demonstrated reducing daily asthma symptoms, nocturnal awakening and night time symptom, shortness of  breath and SABA using. An  asthma control improvement was observed after 1 month treatment (Δ ACQ-5 1.6 [1.2; 2.4], p = 0.0002 compared to the baseline data) with a continued tendency to further increase during 6 months of the study. A statistically significant increase in FEV1 was noted (initially, FEV1 56.7% [51.25; 61.8] of the predicted; after 1 month, FEV1 67.5% [63.45; 70.6] of the predicted, p = 0.00003; after 6 months, FEV1 80.6% [80.55; 84.05] of the predicted, p >< 0.001). Omalizumab biosimilar used allowed to reduce the background asthma therapy. No asthma exacerbation was registered due to 26 weeks omalizumab treatment. Conclusions. Based on the results of the study, it was shown that the administration of the omalizumab biosimilar to patients with severe atopic asthma improves control over the symptoms, lung function and reduces the amount of asthma exacerbations, and has a good safety>< 80% of the predicted normal value). For 26 weeks all patients received the omalizumab. The evaluation of the efficacy was provided taking into account asthma symptoms improvement the results of ACQ-5, FEV1, PEF, asthma exacerbations and the use of health resources.Results. According to the results of data analysis due to omalizumab all patients demonstrated reducing daily asthma symptoms, nocturnal awakening and night time symptom, shortness of  breath and SABA using. An  asthma control improvement was observed after 1 month treatment (Δ ACQ-5 1.6 [1.2; 2.4], p = 0.0002 compared to the baseline data) with a continued tendency to further increase during 6 months of the study. A statistically significant increase in FEV1 was noted (initially, FEV1 56.7% [51.25; 61.8] of the predicted; after 1 month, FEV1 67.5% [63.45; 70.6] of the predicted, p = 0.00003; after 6 months, FEV1 80.6% [80.55; 84.05] of the predicted, p < 0.001). Omalizumab biosimilar used allowed to reduce the background asthma therapy. No asthma exacerbation was registered due to 26 weeks omalizumab treatment.Conclusions. Based on the results of the study, it was shown that the administration of the omalizumab biosimilar to patients with severe atopic asthma improves control over the symptoms, lung function and reduces the amount of asthma exacerbations, and has a good safety

Когнитивная нейронаука: вызов времени

Original manuscript received February 26, 2020.Revised manuscript accepted March 30, 2020.The full text of the materials is presented in S. V. Popova & A. A. Pechenkina (Eds.) (2020). Cognitive Neuroscience — 2019: Materials of the International Forum. Yekaterinburg: UrFU. The International Forum “Cognitive Neuroscience — 2019” was supported by the Russian Foundation for Basic Research, project № 19‑013‑20191.Ural Federal University named after the first President of Russia B. N. Yeltsin in Yekaterinburg welco med participants of the II International Forum “Cognitive Neuroscience — 2019” in November 2019. More than 300 Russian and foreign scientists took part in the Forum. A total 85 reports were presented. This article is the final report about the Forum. The article presents relevant research directions that have become the subject of discussion by the Forum participants, a scope of Forum research areas and prospects for the development of cognitive neuroscience in general.В ноябре 2019 г. на базе Уральского федерального университета имени первого Президента России Б. Н. Ельцина в г. Екатеринбурге прошел II Международный форум по когнитивным нейронаукам “Cognitive Neuroscience — 2019”. В работе форума участвовали более 300 российских и зарубежных ученых. Всего было представлено 85 докладов. В статье рассмотрены тематические направления работы форума. Представлены актуальные исследования, которые стали предметом обсуждения среди участников форума, проведен анализ работы разных направлений форума и сделаны выводы о дальнейших перспективах развития когнитивной нейронауки в целом