Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obtained before onset of the disease is associated with increased risk of breast cancer. We report on three independent prospective nested case-control studies from the European Prospective Investigation into Cancer and Nutrition (EPIC-Italy; n = 162 matched case-control pairs), the Norwegian Women and Cancer study (NOWAC; n = 168 matched pairs), and the Breakthrough Generations Study (BGS; n = 548 matched pairs). We used the Illumina 450k array to measure methylation in the EPIC and NOWAC cohorts. Whole-genome bisulphite sequencing (WGBS) was performed on the BGS cohort using pooled DNA samples, combined to reach 50× coverage across ~16 million CpG sites in the genome including 450k array CpG sites. Mean β values over all probes were calculated as a measurement for epigenome-wide methylation

Levantamento da contribuição da fixação biológica de nitrogênio para a cultura da cana-de-açúcar no Brasil.

Levantamento da FBN.bitstream/CNPAB-2010/27414/1/doc144.pd

Fertbrasil: an innovative network for the development of tropical soils fertilizers.

This paper aims to present the FertBrasil network, a network leaded by the Brazilian Agricultural Research Corporation ? Embrapa, that includes more than three hundreds of researchers in more than fifty institutions, among public agents, universities and private companies. First, we introduce the subject of network innovation and a little background on tropical fertilizers. Then, we present the FertBrasil network, since its creation, passing by its leadership, partners and the products the network intends to develop. After, a little is discussed about the innovative control mechanism of the network and the product development flow, as well as the interaction between FertBrasil and other governmental initiatives or public policies about the same subject. At least, we discuss about the results of the network until now, in terms of products, technologies and political impacts and mobilization in fertilizers research for tropical regions. Then, we conclude presenting some challenges for FertBrasil network as well as reinforcing the important role assumed by this network in contributing to Brazil keeps its high position in agricultural production and productivity

The "Unromantic Pictures" of Quantum Theory

I am concerned with two views of quantum mechanics that John S. Bell called ``unromantic'': spontaneous wave function collapse and Bohmian mechanics. I discuss some of their merits and report about recent progress concerning extensions to quantum field theory and relativity. In the last section, I speculate about an extension of Bohmian mechanics to quantum gravity.Comment: 37 pages LaTeX, no figures; written for special volume of J. Phys. A in honor of G.C. Ghirard

Eficiência agronômica da mistura de uréia com zeolita natural aplicada na cultura da roseira (Rosa spp.), Nova Friburgo, RJ.

Com objetivo de avaliar a eficiência agronômica da mistura de uréia com zeolita natural (arenito zeolítico), realizou-se experimento em área de produção comercial de flores de corte em Nova Friburgo, RJ, Brasil. Foram realizadas duas adubações de cobertura na cultura da roseira com duas doses de uréia (60 e 120 kg N. ha-1 ) misturadas ou não com arenito zeolítico, na proporção de 20% p/p. As colheitas foram avaliadas quantitativamente, através do total de hastes (HT), massa fresca (MFT) e massa seca (MST) produzidas, e qualitativamente, através da divisão em hastes curtas (HC), médias (HM) e longas (HL). Determinou-se também a extração total de N pelas hastes comerciais colhidas (EXTNH) e a eficiência agronômica dos fertilizantes (EAF). A eficiência agronômica dos fertilizantes (EAF) sobre as produções de HT, MFT, MST e EXTNH é elevada pelo efeito do arenito zeolítico, e a maior influência sobre HT provém do aumento nas produções de HL, elevando a qualidade das hastes produzidas. A mistura de arenito zeolítico com uréia mantém maior quantidade de N-uréia no sistema solo-planta, liberando o nutriente lentamente para a solução do solo, em sincronia com as demandas nutricionais das plantas, resultando no aumento da eficiência agronômica dos fertilizantes avaliados. O arenito zeolítico (CETEM) apresenta características favoráveis para uso em desenvolvimento de fertilizantes nitrogenados de liberação lenta, principalmente com objetivo de aumentar a eficiência agronômica dos fertilizantes