Efficacy of Elaborated Semantic Features Analysis in Aphasia: a quasi-randomised controlled trial

Background: Word finding difficulty is one of the most common features of aphasia. Semantic Features Analysis (SFA) directly aims to improve word finding in people with aphasia. Evidence from systematic reviews suggests that SFA leads to positive outcomes, yet the evidence comprises single case studies and case series. There is a need to evaluate the efficacy of SFA in controlled group studies/trials. Aims: To evaluate the efficacy of Elaborated Semantic Feature Analysis (ESFA) for word finding in people with aphasia. We investigated: (a) the efficacy of ESFA versus a delayed therapy/control, (b) the efficacy of two therapy approaches– individual versus a combination of individual and group therapy. Methods and procedures: We ran a multi-centre, quasi-randomised controlled trial, nested in a larger study (Thales-Aphasia). Participants were recruited from community settings. They had to be people with aphasia due to stroke at least four months post-onset. Participants were randomized to individual vs combination vs delayed therapy/control groups. Both therapy groups had three hours of ESFA per week for 12 weeks. Delayed therapy/control group had no intervention for 12 weeks and were then randomized to either individual or combination therapy. The primary outcome was confrontation naming. Secondary outcomes were the Boston Naming Test, Discourse, the Functional Assessment of Communication Skills for adults (ASHA–FACS), the Stroke and Aphasia Quality of Life scale (SAQOL-39g), the General Health Questionnaire-12 item, and the EQ-5D. Outcomes and Results: Of the 72 participants of the Thales-Aphasia project, 58 met eligibility criteria for speech-language therapy and 39 were allocated to ESFA. The critical p-value was adjusted for multiple comparisons (.005). For the therapy versus control comparison, there was a significant main effect of time on the primary outcome (p<.001, η2p=.42) and a significant interaction effect (p=.003, η2p=.21). An interaction effect for the SAQOL-39g (p=.015, η2p=.11) and its psychosocial domain (p=.013, η2p=.12) did not remain significant after Bonferroni adjustment. For the individual versus combination ESFA comparison, there were significant main effects of time on the primary outcome (p<.001, η2p=.49), the BNT (p<.001, η2p=.29) and the ASHA-FACS (p=.001, η2p=.18). Interaction and group effects were not significant. Conclusion: Though underpowered, this study provides evidence on the efficacy of ESFA to improve word finding in aphasia, with gains similar in the two therapy approaches. Trial registration: ISRCTN71455409, https://doi.org/10.1186/ISRCTN7145540

Fluid Flow and Infiltration in Structured Fibrous Porous Media

Present the results of an extensive computational investigation of flow through structured fibrous media

Proton conductivity and luminiscence properties of lanthanide aminotriphosphonates

Metal phosphonates are multifunctional solids with tunable properties, such as internal H-bond networks, and high chemical and thermal stability [1]. In the present work, we describe the synthesis, structural characterization, luminescent properties and proton conduction performance of a new family of isostructural cationic compounds with general formula [Ln(H4NMP)(H2O)2]Cl·2H2O [Ln = La3+, Pr3+, Sm3+, Gd3+, Tb3+, Dy3+, Ho3+, H6NMP = nitrilotris(methylphosphonic acid)]. These solids are formed by positively charge layers, which consist of isolated LnO8 polyhedra and bridge chelating NMP2- ligands, held apart by chloride ions and water molecules. This arrangement result in extended interlayer hydrogen networks with possible proton transfer pathways. The proton conductivity of Gd3+ sample, selected as prototype of the series, was measured. In the range between range 25º and 80 ºC, the conductivity increase with the temperature up to a maximum value of 3.10-4 S·cm-1, at relative humidity of 95 %. The activation energy obtained from the Arrhenius plot (Figure 1) is in the range corresponding to a Grotthuss transfer mechanism.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. FQM-1656; MAT2013-41836-R

OBTAINING THE DIMENSIONS AND ORIENTATION OF 2D RECTANGULAR FLAKES FROM SECTIONING EXPERIMENTS IN FLAKE COMPOSITES

Recently, we developed and reported the statistical validity of two methods for determining the planar aspect ratios of two-dimensional (2D) rectangular flakes in composites from the statistics of intersection lengths: one method is based on the maximum intersection length, and the other on the average intersection length. In this work, we show that these methods are valid and robust not only for flakes having isotropic, random in-plane orientations, but for the more general situations of planar orientations ranging from unidirectional (misalignment angle e = 0), to partially aligned (0 < e < p/2), to flakes of isotropic, random-in-plane orientations (e = p/2). We prove, by Monte Carlo simulations and by numerical sectioning experiments, the validity of the proposed methods for characterizing the extent of the partial alignment (the misalignment angle e) of 2D rectangular flakes in composites, based again on the statistics of the intersection lengths; this information can be obtained from cross-sections of composite samples used in optical or electron microscopy or using tomographic imaging techniques. The performance of these techniques was tested using blind experiments in numerically sectioned composites which contained up to 106 individual flakes, and was found to be very good for a wide range of flake aspect ratios

A NOVEL METHOD FOR THE DETERMINATION OF THE LATERAL DIMENSIONS OF 2D RECTANGULAR FLAKES

We present a novel method for the determination of the lateral dimensions of thin rectangular flakes, as they exist randomly dispersed in flake composites. Knowledge of flake size and shape is essential for the correct prediction of the mechanical, electrical, thermal and barrier properties of flake composites. The required information is the distribution function of lengths of the lines representing the intersection of flakes with a sectioning plane, as seen in cross-sections of composite samples used in optical or electron microscopy or obtained using tomographic imaging techniques. The key observation is that the major peak of the distribution function coincides with the short dimension S of the flake while a secondary peak corresponds to its long dimension W. These observations are explained using Monte-Carlo simulations, as well as deterministic, geometry-based modeling and probability analysis. Since the strength of the secondary peak diminishes with increasing flake aspect ratio r = W/S, we develop two additional methods for the determination of W. The first finds W from the maximum intersection length; this procedure is justified by computing the relevant probability fields through Monte-Carlo simulations. The second method finds r from the average intersection length and is valid in the range 1 < r < 15. The performance of these techniques is tested and found to be very good using blind experiments in numerically sectioned specimens

Computational Analysis of Transport Across Flake-Filled Composites of Realistic Microstructure

In this paper we present the results of a computational study of diffusion across disordered flake composites in which the flakes are misaligned with respect to the direction of bulk diffusion. We evaluate the effect of flake orientation as well as the influence of boundary conditions and unit-cell types on the predicted barrier properties. Flake orientation impacts very significantly on the barrier properties in flake-filled composites, and usually the key objective in their fabrication is to orient them as close as possible to being perpendicular to the direction of macroscopic diffusion. Our computations are carried out in two-dimensional, doubly-periodic unit cells, each containing up to 3000 individual flake cross-sections. We consider high aspect ratio (alpha) systems with alpha=1000, from the dilute (alpha phi=0.01) and into the very concentrated (alpha phi=40) regime. The effective diffusivity of the corresponding unit cells is computed from the imposed concentration difference and the computed mass flux, using Fick's Law. We show that use of cyclic boundary conditions and doubly-periodic unit cells results in effective diffusivities which are in agreement with theory and invariant of the shape of the unit cell. We also show that the use of adiabatic boundary conditions produces erroneous results at high flake concentrations. Finally we compare our results to the predictions of existing literature models and find that the latter deviate significantly from computation at high flake concentrations

Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low-density lipoprotein and exhibit decreased activity of the lipoprotein-associated phospholipase A(2)

Rheumatoid arthritis is a chronic inflammatory disease, associated with an excess of cardiovascular morbidity and mortality due to accelerated atherosclerosis. Oxidized low-density lipoprotein (oxLDL), the antibodies against oxLDL and the lipoprotein-associated phospholipase A(2 )(Lp-PLA(2)) may play important roles in inflammation and atherosclerosis. We investigated the plasma levels of oxLDL and Lp-PLA(2 )activity as well as the autoantibody titers against mildly oxLDL in patients with early rheumatoid arthritis (ERA). The long-term effects of immunointervention on these parameters in patients with active disease were also determined. Fifty-eight ERA patients who met the American College of Rheumatology criteria were included in the study. Patients were treated with methotrexate and prednisone. Sixty-three apparently healthy volunteers also participated in the study and served as controls. Three different types of mildly oxLDL were prepared at the end of the lag, propagation and decomposition phases of oxidation. The serum autoantibody titers of the IgG type against all types of oxLDL were determined by an ELISA method. The plasma levels of oxLDL and the Lp-PLA(2 )activity were determined by an ELISA method and by the trichloroacetic acid precipitation procedure, respectively. At baseline, ERA patients exhibited elevated autoantibody titers against all types of mildly oxLDL as well as low activity of the total plasma Lp-PLA(2 )and the Lp-PLA(2 )associated with the high-density lipoprotein, compared with controls. Multivariate regression analysis showed that the elevated autoantibody titers towards oxLDL at the end of the decomposition phase of oxidation and the low plasma Lp-PLA(2 )activity are independently associated with ERA. After immunointervention autoantibody titers against all types of oxLDL were decreased in parallel to the increase in high-density lipoprotein-cholesterol and high-density lipoprotein-Lp-PLA(2 )activity. We conclude that elevated autoantibody titers against oxLDL at the end of the decomposition phase of oxidation and low plasma Lp-PLA(2 )activity are feature characteristics of patients with ERA, suggesting an important role of these parameters in the pathophysiology of ERA as well as in the accelerated atherosclerosis observed in these patients

The impact of technical and environmental conditions on the quality assessment in mammography

Introduction Mammography requires optimal image quality and that should be ensured during quality assurance. This study investigates the impact of environmental conditions and monitor specifications on quality control procedures within image acquisition rooms in breast imaging departments. Methods During this study, nine TORMAM test object images acquired under different conditions were evaluated by 16 observers in 12 different environmental conditions (low, medium, and high illumination level, white and grey wall colour and 2 monitors with high and low technical characteristics). Visibility of structures was the key criteria. Results The number of visible structures per image was dependent on the different environmental conditions, with large variations observed. The wall colour and the illumination level have a statistically significant effect on the number of visible structures. It was statistically proven that the grey wall colour had a positive effect on the visibility of low contrast detail discs. Conclusion Low ambient light, with a grey wall colour and monitors with high specification allow greatest structure visibility. On the contrary, white wall colour around the monitor and high ambient light had a negative impact on technical evaluation of the images during quality control procedures. Implications for practice Better standardization of the environmental condition is required in acquisition rooms. Specifically, this research points to the benefit of using a low reflectance wall colour and low illumination level around the monitors

Leiomyosarcoma of the Penis

We report a case of a 78-year-old patient with penile leiomyosarcoma, treated by radical penectomy. Two years after the operation the patient is without evidence of local recurrence or metastatic disease.We also discuss the treatment options and attempt a review of the literature

The Morphology of N=6 Chern-Simons Theory

We tabulate various properties of the language of N=6 Chern-Simons Theory, in the sense of Polyakov. Specifically we enumerate and compute character formulas for all syllables of up to four letters, i.e. all irreducible representations of OSp(6|4) built from up to four fundamental fields of the ABJM theory. We also present all tensor product decompositions for up to four singletons and list the (cyclically invariant) four-letter words, which correspond to single-trace operators of length four. As an application of these results we use the two-loop dilatation operator to compute the leading correction to the Hagedorn temperature of the weakly-coupled planar ABJM theory on R \times S^2.Comment: 41 pages, 1 figure; v2: minor correction