Effects of diets high in animal or plant protein on oxidative stress in individuals with type 2 diabetes: a randomized clinical trial

High-protein diet is a promising strategy for diabetes treatment supporting body weight control, improving glycaemic status, cardiovascular risk factors and reducing liver fat. Here, we investigated effects of diets high in animal (AP) or plant (PP) protein on oxidative stress and antioxidant status in individuals with type 2 diabetes (T2DM). 37 obese individuals (age 64.3 ± 1.0 years) with T2DM were randomized to an isocaloric diet (30 energy(E)% protein, 30E% fat and 40E% carbohydrates) rich in AP or PP for 6 weeks. Markers of oxidative and nitrosative stress and antioxidant status in plasma and nitrate/nitrite levels in urine were assessed. Gene expression in subcutaneous adipose tissue (SAT) was analyzed by RNA-Seq and real-time PCR.Both AP and PP diets similarly reduced plasma levels of malondialdehyde (P(AP) = 0.003, P(PP) = 1.6x10(-4)) and protein carbonyls (P(AP) = 1.2x10(-4), P(PP) = 3.0x10(-5)) over 6 weeks. Nitrotyrosine (NT) increased upon both AP and PP diets (PAP = 0.005,PPP = 0.004). SAT expression of genes involved in nitric oxide (NO) and oxidative stress metabolism and urine NO metabolite (nitrate/nitrite) levels were not changed upon both diets. Plasma levels of carotenoids increased upon PP diet, whereas retinol, alpha- and gamma-tocopherol slightly decreased upon both diets. AP and PP diets similarly improve oxidative stress but increase nitrosative stress markers in individuals with T2DM. Mechanisms of the NT regulation upon high-protein diets need further investigation

Корреляционные зависимости для определения выгорания и содержания актинидов в облученном ядерном топливе

Correlation dependencies have been obtained to determine the burn­out and content of actinides in spent nuclear fuel based on an analysis of published experimental data on the definition of burnout and isotopic composition of spent nuclear fuel rods for samples of PWR and VVER reactor types using statistical methods. Given dependencies of the mass concentration of actinides at the end of irradiation after checking for normality correspond to the initial experimental data. These relationships may be of interest to use for non­destructive methods for the purpose of express evaluation of spent nuclear fuel burnout at all stages of the nuclear cycle.Получены корреляционные зависимости для определения выгорания и содержания актинидов в облученном ядерном топливе на основании анализа опубликованных экспериментальных данных по определению выгорания и изотопного состава облученного ядерного топлива для образцов твэлов реакторов PWR и ВВЭР с использованием статистических методов. Корреляционные зависимости по определению массовой концентрации актинидов по окончании облучения после проверки на нормальность соответствуют исходным экспериментальным данным. Эти зависимости могут представить интерес для использования методов неразрушающего контроля с целью проведения экспрессной оценки выгорания и содержания компонентов ОЯТ на всех этапах ядерного цикла

ДВУМЕРНАЯ МОДЕЛЬ ДЛЯ ОБОСНОВАНИЯ БЕЗОПАСНОСТИ ПУНКТОВ ЗАХОРОНЕНИЯ РАДИОАКТИВНЫХ ОТХОДОВ

Single-dimensional models of contaminants migration in soil do not always adequately reflect the processes that occur in real life. Transition to two- or three- dimensional modeling would help enormously improving accuracy of calculations.Одномерные модели переноса загрязнения в грунте не всегда адекватно отражают реально происходящие процессы. Переход к двумерной или трехмерной моделям позволяет многократно повысить точность расчетов

Shotgun Lipidomics Discovered Diurnal Regulation of Lipid Metabolism Linked to Insulin Sensitivity in Nondiabetic Men.

Meal timing affects metabolic homeostasis and body weight, but how composition and timing of meals affect plasma lipidomics in humans is not well studied