Macrolide antibiotics and their place in therapy of upper respiratory tract infections therapy

The problem of therapy of acute ENT-organs infections is far from final resolution, despite the fact that peculiarities of their course are sufficiently well studied. What is the reason of it? There is no decisive answer so far. The choice of antibacterial drug and ways to administer it is still a complicated task for the practical ENT-specialist. When prescribing the antibiotic it’s necessary to rely on certain algorithms developed with the aim to provide the maximum therapeutic effectiveness and prevention of antibiotic resistant strains selection. The latter provision provides for a possibility to manipulate antibiotics of choice and rescue drugs

A novel function for SNAP29 (synaptosomal-associated protein of 29 kDa) in mast cell phagocytosis.

Mast cells play a critical role in the innate immune response to bacterial infection. They internalize and kill a variety of bacteria and process antigen for presentation to T cells via MHC molecules. Although mast cell phagocytosis appears to play a significant role during bacterial infection, little is known about the proteins involved in its regulation. In this study, we demonstrate that the SNARE protein SNAP29 is involved in mast cell phagocytosis. SNAP29 is localized in the endocytic pathway and is transiently recruited to Escherichia coli (E. coli)-containing phagosomes. Interestingly, overexpression of SNAP29 significantly increases the internalization and killing of E. coli, while it does not affect mast cell exocytosis of inflammatory mediators. To our knowledge, these data are the first to demonstrate a novel function of SNAP29 in mast cell phagocytosis and have implications in protection against bacterial infection