Brillouin instabilities in continuously pumped high power fiber lasers

The effect of Brillouin backscattering on the stability of a high power continuously pumped fiber laser is theoretically analyzed in the general framework of two-coupled modes laser model. It is demonstrated that, depending on the cavity losses, different type of instabilities can arise. Low loss cavity favours stable continuous regime in a large range of pumping rates while high loss configuration permits the emergence of different self-pulsing instabilities

Instabilities in high power fiber lasers induced by stimulated Brillouin scattering

We investigate numerically different types of instabilities in a high loss Fabry–Perot laser cavity in presence of the stimulated Brillouin scattering. Our results reveal many interesting dynamical behaviors such as periodic, quasi-periodic and chaotic

Brillouin instabilities in high power fiber lasers

With the emergence of rare-earth doped fibers, and especially double-clad fibers, there is a renewed interest in Brillouin effect. First of all, the amplification of a continuous signal in a rare-earth doped fiber amplifier can generate high enough intensities to excite Brillouin effect and then to create a backscattered stokes wave. Such back-reflection is detrimental for amplifier applications and consequently it has been studied theoretically and experimentally. Recently, the low frequency self-pulsing instability resulting from Brillouin backscattering has been theoretically modelled [1]. Our main objective is to present a general model allowing to explain the origin of the dynamic instability arising in a fiber lasers as a consequence of Brillouin effect. The effect of Brillouin back scattering is theoretically analysed by two-coupled modes laser model. We consider the Fabry-Perot fiber laser cavity. The rich and complex dynamic behaviours are observed. In particular the quasi periodic dynamic is identified and studied

Strong Purcell effect observed in single thick shell CdSe/CdS nanocrystals coupled to localized surface plasmons

High quality factor dielectric cavities designed to a nanoscale accuracy are mostly used to increase the spontaneous emission rate of a single emitter. Here we show that the coupling, at room temperature, between thick shell CdSe/CdS nanocrystals and random metallic films offers a very promising alternative approach. Optical modes confined at the nanoscale induce strong Purcell factors reaching values as high as 60. Moreover the quantum emission properties can be tailored: strong antibunching or radiative biexcitonic cascades can be obtained with high photon collection efficiency and extremely reduced blinking.Comment: 16 pages, 7 figure

Influence of higher-order stimulated Brillouin scattering on the occurrence of extreme events in self-pulsing fiber lasers

We investigate the dynamical behavior of a self-pulsing laser under the influence of stimulated Brillouin scattering (SBS), a system which has previously been shown to favor extreme statistics. Using a laser model coupling a multi-Stokes Brillouin scattering process with the population inversion formalism for the gain and taking into account saturable absorption effects, we demonstrate that different statistical distribution types arise as the nonlinear interactions between the laser and higher-order SBS waves lead to the occurrence of high intensity short pulses. By taking into account up to five Stokes orders, we show that highly skewed statistics and pulses with extreme peak intensities can be obtained, allowing us to describe more accurately the experimental observations and to better apprehend the underlying physics.We also unexpectedly demonstrate that the acoustic noise does not affect the emergence of such extreme events

Dose selection for radioiodine therapy of borderline hyperthyroid patients according to thyroid uptake of 99mTc-pertechnetate: applicability to unifocal thyroid autonomy?

PURPOSE: The aim of this study was to evaluate the feasibility of applying a previously described dose strategy based on (99m)Tc-pertechnetate thyroid uptake under thyrotropin suppression (TcTU(s)) to radioiodine therapy for unifocal thyroid autonomy. METHODS: A total of 425 consecutive patients (302 females, 123 males; age 63.1+/-10.3 years) with unifocal thyroid autonomy were treated at three different centres with (131)I, using Marinelli's formula for calculation of three different absorbed dose schedules: 100-300 Gy to the total thyroid volume according to the pre-treatment TcTU(s) (n=146), 300 Gy to the nodule volume (n=137) and 400 Gy to the nodule volume (n=142). RESULTS: Successful elimination of functional thyroid autonomy with either euthyroidism or hypothyroidism occurred at a mean of 12 months after radioiodine therapy in 94.5% of patients receiving 100-300 Gy to the thyroid volume, in 89.8% of patients receiving 300 Gy to the nodule volume and in 94.4% receiving 400 Gy to the nodule volume. Reduction in thyroid volume was highest for the 100-300 Gy per thyroid and 400 Gy per nodule strategies (36+/-19% and 38+/-20%, respectively) and significantly lower for the 300 Gy per nodule strategy (28+/-16%; p<0.01). CONCLUSION: A dose strategy based on the TcTU(s) can be used independently of the scintigraphic pattern of functional autonomous tissue in the thyroid

Liquid application dosing alters the physiology of air-liquid interface (ALI) primary human bronchial epithelial cell/lung fibroblast co-cultures and in vitro testing relevant endpoints

Differentiated primary human bronchial epithelial cell (dpHBEC) cultures grown under air-liquid interface (ALI) conditions exhibit key features of the human respiratory tract and are thus critical for respiratory research as well as efficacy and toxicity testing of inhaled substances (e.g., consumer products, industrial chemicals, and pharmaceuticals). Many inhalable substances (e.g., particles, aerosols, hydrophobic substances, reactive substances) have physiochemical properties that challenge their evaluation under ALI conditions in vitro. Evaluation of the effects of these methodologically challenging chemicals (MCCs) in vitro is typically conducted by “liquid application,” involving the direct application of a solution containing the test substance to the apical, air-exposed surface of dpHBEC-ALI cultures. We report that the application of liquid to the apical surface of a dpHBEC-ALI co-culture model results in significant reprogramming of the dpHBEC transcriptome and biological pathway activity, alternative regulation of cellular signaling pathways, increased secretion of pro-inflammatory cytokines and growth factors, and decreased epithelial barrier integrity. Given the prevalence of liquid application in the delivery of test substances to ALI systems, understanding its effects provides critical infrastructure for the use of in vitro systems in respiratory research as well as in the safety and efficacy testing of inhalable substances

Liquid application dosing alters the physiology of air-liquid interface (ALI) primary human bronchial epithelial cell/lung fibroblast co-cultures and in vitro testing relevant endpoints

Differentiated primary human bronchial epithelial cell (dpHBEC) cultures grown under air-liquid interface (ALI) conditions exhibit key features of the human respiratory tract and are thus critical for respiratory research as well as efficacy and toxicity testing of inhaled substances (e.g., consumer products, industrial chemicals, and pharmaceuticals). Many inhalable substances (e.g., particles, aerosols, hydrophobic substances, reactive substances) have physiochemical properties that challenge their evaluation under ALI conditions in vitro. Evaluation of the effects of these methodologically challenging chemicals (MCCs) in vitro is typically conducted by “liquid application,” involving the direct application of a solution containing the test substance to the apical, air-exposed surface of dpHBEC-ALI cultures. We report that the application of liquid to the apical surface of a dpHBEC-ALI co-culture model results in significant reprogramming of the dpHBEC transcriptome and biological pathway activity, alternative regulation of cellular signaling pathways, increased secretion of pro-inflammatory cytokines and growth factors, and decreased epithelial barrier integrity. Given the prevalence of liquid application in the delivery of test substances to ALI systems, understanding its effects provides critical infrastructure for the use of in vitro systems in respiratory research as well as in the safety and efficacy testing of inhalable substances

Brillouin scattering-induced rogue waves in self-pulsing fiber lasers

We report the experimental observation of extreme instabilities in a self-pulsing fiber laser under the influence of stimulated Brillouin scattering (SBS). Specifically, we observe temporally localized structures with high intensities that can be referred to as rogue events through their statistical behaviour with highly-skewed intensity distributions. The emergence of these SBS-induced rogue waves is attributed to the interplay between laser operation and resonant Stokes orders. As this behaviour is not accounted for by existing models, we also present numerical simulations showing that such instabilities can be observed in chaotic laser operation. This study opens up new possibilities towards harnessing extreme events in highly-dissipative systems through adapted laser cavity configurations