Sound radiation in turbulent channel flows

Lighthill’s acoustic analogy is formulated for turbulent channel flow with pressure as the acoustic variable, and integrated over the channel width to produce a two-dimensional inhomogeneous wave equation. The equivalent sources consist of a dipole distribution related to the sum of the viscous shear stresses on the two walls, together with monopole and quadrupole distributions related to the unsteady turbulent dissipation and Reynolds stresses respectively. Using a rigid-boundary Green function, an expression is found for the power spectrum of the far-field pressure radiated per unit channel area. Direct numerical simulations (DNS) of turbulent plane Poiseuille and Couette flow have been performed in large computational domains in order to obtain good resolution of the low-wavenumber source behaviour. Analysis of the DNS databases for all sound radiation sources shows that their wavenumber–frequency spectra have non-zero limits at low wavenumber. The sound power per unit channel area radiated by the dipole distribution is proportional to Mach number squared, while the monopole and quadrupole contributions are proportional to the fourth power of Mach number. Below a particular Mach number determined by the frequency and radiation direction, the dipole radiation due to the wall shear stress dominates the far field. The quadrupole takes over at Mach numbers above about 0.1, while the monopole is always the smallest term. The resultant acoustic field at any point in the channel consists of a statistically diffuse assembly of plane waves, with spectrum limited by damping to a value that is independent of Mach number in the low-M limit

Classical Propagation of Strings across a Big Crunch/Big Bang Singularity

One of the simplest time-dependent solutions of M theory consists of nine-dimensional Euclidean space times 1+1-dimensional compactified Milne space-time. With a further modding out by Z_2, the space-time represents two orbifold planes which collide and re-emerge, a process proposed as an explanation of the hot big bang. When the two planes are near, the light states of the theory consist of winding M2-branes, describing fundamental strings in a particular ten-dimensional background. They suffer no blue-shift as the M theory dimension collapses, and their equations of motion are regular across the transition from big crunch to big bang. In this paper, we study the classical evolution of fundamental strings across the singularity in some detail. We also develop a simple semi-classical approximation to the quantum evolution which allows one to compute the quantum production of excitations on the string and implement it in a simplified example.Comment: 38 pages, 19 figure

ECONOMIC, ENVIRONMENTAL AND ENERGY USE IMPLICATIONS OF SHORT-SEASON COTTON PRODUCTION: TEXAS LOWER RIO GRANDE VALLEY

Crop Production/Industries,

Ground state and constrained domain walls in Gd/Fe multilayers

The magnetic ground state of antiferromagnetically coupled Gd/Fe multilayers and the evolution of in-plane domain walls is modelled with micromagnetics. The twisted state is characterised by a rapid decrease of the interface angle with increasing magnetic field. We found that for certain ratios M(Fe):M(Gd), the twisted state is already present at low fields. However, the magnetic ground state is not only determined by the ratio M(Fe):M(Gd) but also by the thicknesses of the layers, that is the total moments of the layer. The dependence of the magnetic ground state is explained by the amount of overlap of the domain walls at the interface. Thicker layers suppress the Fe aligned and the Gd aligned state in favour of the twisted state. Whereas ultrathin layers exclude the twisted state, since wider domain walls can not form in these ultrathin layers

Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells.

Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid leukemia (AML). Inhibitors to FLT3 have already been tested in clinical trials, however, drug resistance limits clinical efficacy. Mutant receptor tyrosine kinases are mislocalized in the endoplasmic reticulum (ER) of AML and play an important role in the non-canonical activation of signal transducer and activator of transcription 5 (STAT5). Here, we have tested a potent new drug called imipramine blue (IB), which is a chimeric molecule with a dual mechanism of action. At 200-300 nM concentrations, IB is a potent inhibitor of STAT5 through liberation of endogenous phosphatase activity following NADPH oxidase (NOX) inhibition. However, at 75-150 nM concentrations, IB was highly effective at killing mutant FLT3-driven AML cells through a similar mechanism as thapsigargin (TG), involving increased cytosolic calcium. IB also potently inhibited survival of primary human FLT3/ITD+ AML cells compared to FLT3/ITDneg cells and spared normal umbilical cord blood cells. Therefore, IB functions through a mechanism involving vulnerability to dysregulated calcium metabolism and the combination of fusing a lipophilic amine to a NOX inhibiting dye shows promise for further pre-clinical development for targeting high risk AML

Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection

This work was supported by the National Institutes of Health (R01AI080275 and R21AI22352), the NIH Fogarty International Center (R25TW009345), the University of Minnesota Center for Translational Science Institute (UL1TR000114), Wellcome Trust (086827, 075470, 097377, 101873 & 200208) and MRC Centre for Medical Mycology (N006364/1). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.Peer reviewedPublisher PD