Two-scale convergence for locally-periodic microstructures and homogenization of plywood structures

The introduced notion of locally-periodic two-scale convergence allows to average a wider range of microstructures, compared to the periodic one. The compactness theorem for the locally-periodic two-scale convergence and the characterisation of the limit for a sequence bounded in $H^1(\Omega)$ are proven. The underlying analysis comprises the approximation of functions, which periodicity with respect to the fast variable depends on the slow variable, by locally-periodic functions, periodic in subdomains smaller than the considered domain, but larger than the size of microscopic structures. The developed theory is applied to derive macroscopic equations for a linear elasticity problem defined in domains with plywood structures.Comment: 22 pages, 4 figure

Evaluation of entropy and JM-distance criterions as features selection methods using spectral and spatial features derived from LANDSAT images

A study area near Ribeirao Preto in Sao Paulo state was selected, with predominance in sugar cane. Eight features were extracted from the 4 original bands of LANDSAT image, using low-pass and high-pass filtering to obtain spatial features. There were 5 training sites in order to acquire the necessary parameters. Two groups of four channels were selected from 12 channels using JM-distance and entropy criterions. The number of selected channels was defined by physical restrictions of the image analyzer and computacional costs. The evaluation was performed by extracting the confusion matrix for training and tests areas, with a maximum likelihood classifier, and by defining performance indexes based on those matrixes for each group of channels. Results show that in spatial features and supervised classification, the entropy criterion is better in the sense that allows a more accurate and generalized definition of class signature. On the other hand, JM-distance criterion strongly reduces the misclassification within training areas

A Fabry-Perot interferometer with quantum mirrors: nonlinear light transport and rectification

Optical transport represents a natural route towards fast communications, and it is currently used in large scale data transfer. The progressive miniaturization of devices for information processing calls for the microscopic tailoring of light transport and confinement at length scales appropriate for the upcoming technologies. With this goal in mind, we present a theoretical analysis of a one-dimensional Fabry-Perot interferometer built with two highly saturable nonlinear mirrors: a pair of two-level systems. Our approach captures non-linear and non-reciprocal effects of light transport that were not reported previously. Remarkably, we show that such an elementary device can operate as a microscopic integrated optical rectifier

Equilibrium and Disorder-induced behavior in Quantum Light-Matter Systems

We analyze equilibrium properties of coupled-doped cavities described by the Jaynes-Cummings- Hubbard Hamiltonian. In particular, we characterize the entanglement of the system in relation to the insulating-superfluid phase transition. We point out the existence of a crossover inside the superfluid phase of the system when the excitations change from polaritonic to purely photonic. Using an ensemble statistical approach for small systems and stochastic-mean-field theory for large systems we analyze static disorder of the characteristic parameters of the system and explore the ground state induced statistics. We report on a variety of glassy phases deriving from the hybrid statistics of the system. On-site strong disorder induces insulating behavior through two different mechanisms. For disorder in the light-matter detuning, low energy cavities dominate the statistics allowing the excitations to localize and bunch in such cavities. In the case of disorder in the light- matter coupling, sites with strong coupling between light and matter become very significant, which enhances the Mott-like insulating behavior. Inter-site (hopping) disorder induces fluidity and the dominant sites are strongly coupled to each other.Comment: about 10 pages, 12 figure

A Naturalistic Approach to Training Accurate and Coherent Decision Making in Rugby Union Referees

The purpose of this investigation was to pilot the use of a video-based training program designed to develop referees’ shared mental models. A group of English Rugby Football Union (RFU) national referees, divided into a control group (n = 15) and experimental group (n = 41) made their immediate decisions on pre and posttests of 10 video recordings taken from real game scenarios. Over a six-week period the experimental group studied training tapes consisting of 5 sets of 5 tackles, in each case with an expert providing his interpretation of the correct decision. Each clip was filmed from the referee’s perspective and taken from real game situations in order to maintain high ecological validity in accordance with naturalistic decision-making theory. The lowest ranked referees on the national panel significantly improved their percentage of correct decisions, becoming 17.43% more accurate in their decisions at the posttest. These results suggest that such shared mental model training is an appropriate method for improving referee decision making. \bb\164 words

Linfoma de Hodgkin em Doença de Crohn Medicada com Infliximab

INTRODUCTION: Lymphoproliferative disorders, particularly non-Hodgkin's and Hodgkin's lymphomas, are rare in patients with inflammatory bowel diseases. The use of thiopurines and infection by Epstein-Barr virus are well-known cofactors that can raise its prevalence. Other risk factors such as disease activity and biological treatment are the subject of discussion, without enough data in the literature to confirm a potential association. METHODS: We report a case of Hodgkin's lymphoma in a patient who had been treated with azathioprine and was on long-term monotherapy with infliximab. CONCLUSIONS: We stress the importance of recognizing the possible occurrence of a lymphoproliferative disorder in association with anti-tumor necrosis factor-α therapy.info:eu-repo/semantics/publishedVersio

Larotrectinib efficacy and safety in TRK fusion cancer: An expanded clinical dataset showing consistency in an age and tumor agnostic approach

Background: TRK fusion cancer results from gene fusions involving NTRK1, NTRK2 or NTRK3. Larotrectinib, the first selective TRK inhibitor, has demonstrated an overall response rate (ORR) of 75% with a favorable safety profile in the first 55 consecutively enrolled adult and pediatric patients with TRK fusion cancer (Drilon et al.,NEJM2018). Here, we report the clinical activity of larotrectinib in an additional 35 TRK fusion cancer patients and provide updated follow-up of the primary analysis set (PAS) of 55 patients as of 19thFeb 2018. Methods: Patients with TRK fusion cancer detected by molecular profiling from 3 larotrectinib clinical trials (NCT02122913, NCT02637687, and NCT02576431) were eligible.Larotrectinib was administered until disease progression, withdrawal, or unacceptable toxicity. Disease status was assessed using RECIST version 1.1. Results: As of Feb 2018, by independent review, 6 PRs in the PAS deepened to CRs. The median duration of response (DoR) and progression-free survival in the PAS had still not been reached, with 12.9 months median follow-up. At 1 year, 69% of responses were ongoing, 58% of patients remained progression-free and 90% of patients were alive. An additional 19 children and 25 adults (age range, 0.1-78 years) with TRK fusion cancer were enrolled after the PAS, and included cancers of the salivary gland, thyroid, lung, colon, melanoma, sarcoma, GIST and congenital mesoblastic nephroma. In 35 evaluable patients, the ORR by investigator assessment was 74% (5 CR, 21 PR, 6 SD, 2 PD, 1 not determined). In these patients, with median follow-up of 5.5 months, median DoR had not yet been reached, and 88% of responses were ongoing at 6 months, consistent with the PAS. Adverse events (AEs) were predominantly grade 1, with dizziness, increased AST/ALT, fatigue, nausea and constipation the most common AEs reported in ≥ 10% of patients. No AE of grade 3 or 4 related to larotrectinib occurred in more than 5% of patients. Conclusions: TRK fusions are detected in a broad range of tumor types. Larotrectinib is an effective age- and tumor-agnostic treatment for TRK fusion cancer with a positive safety profile. Screening patients for NTRK gene fusions in solid- and brain tumors should be actively considered

Blood Supply to the Integument of the Abdomen of the Rat: A Surgical Perspective

BACKGROUND: Many fundamental questions regarding the blood supply to the integument of the rat remain to be clarified, namely the degree of homology between rat and humans. The aim of this work was to characterize in detail the macro and microvascular blood supply to the integument covering the ventrolateral aspect of the abdominal wall of the rat. METHODS: Two hundred five Wistar male rats weighing 250-350 g were used. They were submitted to gross anatomical dissection after intravascular colored latex injection (n = 30); conversion in modified Spalteholz cleared specimens (n=10); intravascular injection of a Perspex solution, and then corroded, in order to produce vascular corrosion casts of the vessels in the region (n = 5); histological studies (n = 20); scanning electron microscopy of vascular corrosion casts (n = 10); surgical dissection of the superficial caudal epigastric vessels (n = 100); and to thermographic evaluation (n = 30). RESULTS: The ventrolateral abdominal wall presented a dominant superficial vascular system, which was composed mainly of branches from the superficial caudal epigastric artery and vein in the caudal half. The cranial half still received significant arterial contributions from the lateral thoracic artery in all cases and from large perforators coming from the intercostal arteries and from the deep cranial epigastric artery. CONCLUSIONS: These data show that rats and humans present a great deal of homology regarding the blood supply to the ventrolateral aspect of the abdominal integument. However, there are also significant differences that must be taken into consideration when performing and interpreting experimental procedures in rats.info:eu-repo/semantics/publishedVersio

Comparison of diverse methods for the correction of atmospheric effects on LANDSAT and SKYLAB images

Earth's atmosphere reduces a sensors ability in currently discriminating targets. Using radiometric correction to reduce the atmospheric effects may improve considerably the performance of an automatic image interpreter. Several methods for radiometric correction from the open literature are compared leading to the development of an atmospheric correction system