331 research outputs found
Measuring the Quantum State of a Large Angular Momentum
We demonstrate a general method to measure the quantum state of an angular
momentum of arbitrary magnitude. The (2F+1) x (2F+1) density matrix is
completely determined from a set of Stern-Gerlach measurements with (4F+1)
different orientations of the quantization axis. We implement the protocol for
laser cooled Cesium atoms in the 6S_{1/2}(F=4) hyperfine ground state and apply
it to a variety of test states prepared by optical pumping and Larmor
precession. A comparison of input and measured states shows typical
reconstruction fidelities of about 0.95.Comment: 4 pages, 6 figures, submitted to PR
Resolved-sideband Raman cooling to the ground state of an optical lattice
We trap neutral Cs atoms in a two-dimensional optical lattice and cool them
close to the zero-point of motion by resolved-sideband Raman cooling. Sideband
cooling occurs via transitions between the vibrational manifolds associated
with a pair of magnetic sublevels and the required Raman coupling is provided
by the lattice potential itself. We obtain mean vibrational excitations
\bar{n}_x \approx \bar{n}_y \approx 0.01, corresponding to a population \sim
98% in the vibrational ground state. Atoms in the ground state of an optical
lattice provide a new system in which to explore quantum state control and
subrecoil laser coolingComment: PDF file, 13 pages including 3 figure
Phase Control of Nonadiabaticity-induced Quantum Chaos in An Optical Lattice
The qualitative nature (i.e. integrable vs. chaotic) of the translational
dynamics of a three-level atom in an optical lattice is shown to be
controllable by varying the relative laser phase of two standing wave lasers.
Control is explained in terms of the nonadiabatic transition between optical
potentials and the corresponding regular to chaotic transition in mixed
classical-quantum dynamics. The results are of interest to both areas of
coherent control and quantum chaos.Comment: 3 figures, 4 pages, to appear in Physical Review Letter
Dichotomy of Tyrosine Hydroxylase and Dopamine Regulation between Somatodendritic and Terminal Field Areas of Nigrostriatal and Mesoaccumbens Pathways
Measures of dopamine-regulating proteins in somatodendritic regions are often used only as static indicators of neuron viability, overlooking the possible impact of somatodendritic dopamine (DA) signaling on behavior and the potential autonomy of DA regulation between somatodendritic and terminal field compartments. DA reuptake capacity is less in somatodendritic regions, possibly placing a greater burden on de novo DA biosynthesis within this compartment to maintain DA signaling. Therefore, regulation of tyrosine hydroxylase (TH) activity may be particularly critical for somatodendritic DA signaling. Phosphorylation of TH at ser31 or ser40 can increase activity, but their impact on L-DOPA biosynthesis in vivo is unknown. Thus, determining their relationship with L-DOPA tissue content could reveal a mechanism by which DA signaling is normally maintained. In Brown-Norway Fischer 344 F1 hybrid rats, we quantified TH phosphorylation versus L-DOPA accumulation. After inhibition of aromatic acid decarboxylase, L-DOPA tissue content per recovered TH protein was greatest in NAc, matched by differences in ser31, but not ser40, phosphorylation. The L-DOPA per catecholamine and DA turnover ratios were significantly greater in SN and VTA, suggesting greater reliance on de novo DA biosynthesis therein. These compartmental differences reflected an overall autonomy of DA regulation, as seen by decreased DA content in SN and VTA, but not in striatum or NAc, following short-term DA biosynthesis inhibition from local infusion of the TH inhibitor α-methyl-p-tyrosine, as well as in the long-term process of aging. Such data suggest ser31 phosphorylation plays a significant role in regulating TH activity in vivo, particularly in somatodendritic regions, which may have a greater reliance on de novo DA biosynthesis. Thus, to the extent that somatodendritic DA release affects behavior, TH regulation in the midbrain may be critical for DA bioavailability to influence behavior
State determination in continuous measurement
The possibility of determining the state of a quantum system after a
continuous measurement of position is discussed in the framework of quantum
trajectory theory. Initial lack of knowledge of the system and external noises
are accounted for by considering the evolution of conditioned density matrices
under a stochastic master equation. It is shown that after a finite time the
state of the system is a pure state and can be inferred from the measurement
record alone. The relation to emerging possibilities for the continuous
experimental observation of single quanta, as for example in cavity quantum
electrodynamics, is discussed.Comment: 12 pages, 4 figures, Revte
Multipartite Entanglement and Quantum State Exchange
We investigate multipartite entanglement in relation to the theoretical
process of quantum state exchange. In particular, we consider such entanglement
for a certain pure state involving two groups of N trapped atoms. The state,
which can be produced via quantum state exchange, is analogous to the
steady-state intracavity state of the subthreshold optical nondegenerate
parametric amplifier. We show that, first, it possesses some 2N-way
entanglement. Second, we place a lower bound on the amount of such entanglement
in the state using a novel measure called the entanglement of minimum bipartite
entropy.Comment: 12 pages, 4 figure
Discrepancy between Knowledge and Perceptions of Dietary Omega-3 Fatty Acid Intake Compared with the Omega-3 Index
Little is known about the relationship between perceptions of nutrient adequacy and biomarkers of nutrition status. This cross-sectional study of U.S. and German adults (n = 200;18-80 years) compared dietary practices, knowledge, and beliefs of omega-3 fatty acids (O3-FA) with the omega-3 index (O3-I), an erythrocyte-based biomarker associated with cardiovascular disease (CVD) risk. More than half of adults believed that O3-FAs are beneficial for heart and brain health and could correctly identify the food sources of O3-FA. However, the mean O3-I in the U.S. (4.3%) and Germany (5.5%) puts the majority of adults sampled (99%) in intermediate or high CVD-risk categories. More Americans were considered at high CVD-risk (40%) when compared with Germans (10%). In the U.S., but not Germany, women had a significantly higher O3-I than men (4.8% vs. 3.8%, p < 0.001). In the intermediate CVD-risk group, about one-third of adults in both countries (30% in the U.S. and 27% in Germany) believed their diet was adequate in O3-FA. Notably, mean O3-I concentrations did not significantly differ with dietary perceptions of adequacy. More adults in Germany (26%) than in the U.S. (10%) believed that dietary supplements are needed to achieve a balanced diet. In spite of adequate knowledge about food sources and a consistent belief that O3-FA are important for health, very few participants had O3-I concentrations in the range for CVD protection
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The polygenic nature of telomere length and the anti-ageing properties of lithium
Telomere length is a promising biomarker for age-related disease and a potential anti-ageing drug target. Here, we study the genetic architecture of telomere length and the repositioning potential of lithium as an anti-ageing medication. LD score regression applied to the largest telomere length genome-wide association study to-date, revealed SNP-chip heritability estimates of 7.29%, with polygenic risk scoring capturing 4.4% of the variance in telomere length in an independent cohort (p = 6.17 × 10-5). Gene-enrichment analysis identified 13 genes associated with telomere length, with the most significant being the leucine rich repeat gene, LRRC34 (p = 3.69 × 10-18). In the context of lithium, we confirm that chronic use in a sample of 384 bipolar disorder patients is associated with longer telomeres (p = 0.03). As complementary evidence, we studied three orthologs of telomere length regulators in a Caenorhabditis elegans model of lithium-induced extended longevity and found all transcripts to be affected post-treatment (p  0.05). Consequently, this suggests that lithium may be catalysing the activity of endogenous mechanisms that promote telomere lengthening, whereby its efficacy eventually becomes limited by each individual's inherent telomere maintenance capabilities. Our work indicates a potential use of polygenic risk scoring for the prediction of adult telomere length and consequently lithium's anti-ageing efficacy
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