Promoting adherence to antiretroviral therapy: the experience from a primary care setting in Khayelitsha, South Africa.

OBJECTIVE: To describe the approach used to promote adherence to antiretroviral therapy (ART) and to present the outcomes in the first primary care public sector ART project in South Africa. DESIGN: The study is a prospective open cohort, including all adult patients naive to previous ART who received antiretroviral treatment in Khayelitsha, from May 2001 to the end of 2002. Patients were followed until their most recent visit before 31 July 2003. METHODS: Plasma viral load was determined at 3, 6, 12, 18 and 24 months after ART was initiated, and CD4 cell counts 6-monthly. Kaplan-Meier estimates were determined for the cumulative proportions of patients surviving, and patients with viral load suppression and viral rebound. RESULTS: A total of 287 patients were initiated on triple therapy. The probability of survival was 86.3% at 24 months. The median CD4 cell count gain was 288 cells/microliters at 24 months. Viral load was less than 400 copies/ml in 89.2, 84.2 and 69.7% of patients at 6, 12 and 24 months, respectively. The cumulative probability of viral rebound (two consecutive HIV-RNA measurements above 400 copies/ml) after achieving an HIV-RNA measurement below 400 copies/ml was 13.2% at 18 months. CONCLUSION: The study shows that, with a standard approach to patient preparation and strategies to enhance adherence, a cohort of patients on ART can be retained in a resource-limited setting in a developing country. A high proportion of patients achieved suppression of viral replication. The subsequent probability of viral rebound was low

Polarization of Thermal Emission from Aligned Dust Grains Under an Anisotropic Radiation Field

If aspherical dust grains are immersed in an anisotropic radiation field, their temperature depends on the cross-sections projected in the direction of the anisotropy.It was shown that the temperature difference produces polarized thermal emission even without alignment, if the observer looks at the grains from a direction different from the anisotropic radiation. When the dust grains are aligned, the anisotropy in the radiation makes various effects on the polarization of the thermal emission, depending on the relative angle between the anisotropy and alignment directions. If the both directions are parallel, the anisotropy produces a steep increase in the polarization degree at short wavelengths. If they are perpendicular, the polarization reversal occurs at a wavelength shorter than the emission peak. The effect of the anisotropic radiation will make a change of more than a few % in the polarization degree for short wavelengths and the effect must be taken into account in the interpretation of the polarization in the thermal emission. The anisotropy in the radiation field produces a strong spectral dependence of the polarization degree and position angle, which is not seen under isotropic radiation. The dependence changes with the grain shape to a detectable level and thus it will provide a new tool to investigate the shape of dust grains. This paper presents examples of numerical calculations of the effects and demonstrates the importance of anisotropic radiation field on the polarized thermal emission.Comment: 13pages, 7figure

Viking navigation

A comprehensive description of the navigation of the Viking spacecraft throughout their flight from Earth launch to Mars landing is given. The flight path design, actual inflight control, and postflight reconstruction are discussed in detail. The preflight analyses upon which the operational strategies and performance predictions were based are discussed. The inflight results are then discussed and compared with the preflight predictions and, finally, the results of any postflight analyses are presented

Millimeter- and Submillimeter-Wave Observations of the OMC-2/3 Region. II. Observational Evidence for Outflow-Triggered Star Formation in the OMC-2 FIR 3/4 Region

We have carried out the observations of the OMC-2 FIR 3/4 region with the NMA and ASTE in the H$^{13}$CO$^{+}$ (1--0), $^{12}$CO (3--2, 1--0), SiO ($v$=0, $J$=2--1), CS (2--1), and CH$_3$OH ($J_K$=7$_K$--6$_K$) lines and in the 3.3 mm continuum emission. Our NMA observations in the H$^{13}$CO$^{+}$ emission have revealed 0.07 pc-scale dense gas associated with FIR 4. The $^{12}$CO (3--2,1--0) emission shows high-velocity blue and red shifted components at the both north-east and south-west of FIR 3, suggesting a molecular outflow nearly along the plane of the sky driven by FIR 3. The SiO and the CH$_{3}$OH emission are detected around the interface between the outflow and the dense gas. Furthermore, the $^{12}$CO (1--0) emission shows an L-shaped structure in the P-V diagram. These results imply presence of the shock due to the interaction between the molecular outflow driven by FIR 3 and the dense gas associated with FIR 4. Moreover, our high angular-resolution observations of FIR 4 in the 3.3 mm continuum emission have first found that FIR 4 consists of eleven dusty cores. The separation among these cores is on the same order of the Jeans length, suggesting that the fragmentation into these cores has been caused by the gravitational instability. The time scale of the fragmentation is similar to the time scale of the interaction between the molecular outflow and the dense gas. We suggest that the interaction between the molecular outflow from FIR 3 and the dense gas associated with FIR 4 triggered the fragmentation into these dusty cores, and hence the next generation the cluster formation.Comment: 13 pages, 9 figures. Accepted by Ap

High Resolution Millimeter-Wave Mapping of Linearly Polarized Dust Emission: Magnetic Field Structure in Orion

We present 1.3 and 3.3 mm polarization maps of Orion-KL obtained with the BIMA array at approximately 4 arcsec resolution. Thermal emission from magnetically aligned dust grains produces the polarization. Along the Orion ``ridge'' the polarization position angle varies smoothly from about 10 degrees to 40 degrees, in agreement with previous lower resolution maps. In a small region south of the Orion ``hot core,'' however, the position angle changes by 90 degrees. This abrupt change in polarization direction is not necessarily the signpost of a twisted magnetic field. Rather, in this localized region processes other than the usual Davis-Greenstein mechanism might align the dust grains with their long axes parallel with the field, orthogonal to their normal orientation.Comment: AAS preprint:14 pages, 2 figures (3mm.eps and 1mm.eps); requires aaspp4.sty To be published in Astrophysical Journal Letter

FACT - Threshold prediction for higher duty cycle and improved scheduling

The First G-APD Cherenkov telescope (FACT) is the first telescope using silicon photon detectors (G-APD aka. SiPM). The use of Silicon devices promise a higher photon detection efficiency, more robustness and higher precision than photo-multiplier tubes. Being operated during different light-conditions, the threshold settings of a Cherenkov telescope have to be adapted to feature the lowest possible threshold but also an efficient suppression of triggers from night-sky background photons. Usually this threshold is set either by experience or a mini-ratescan. Since the measured current through the sensors is directly correlated with the noise level, the current can be used to set the best threshold at any time. Due to the correlation between the physical threshold and the final energy threshold, the current can also be used as a measure for the energy threshold of any observation. This presentation introduces a method which uses the properties of the moon and the source position to predict the currents and the corresponding energy threshold for every upcoming observation allowing to adapt the observation schedule accordingly

Mesoscopic phase statistics of diffuse ultrasound in dynamic matter

Temporal fluctuations in the phase of waves transmitted through a dynamic, strongly scattering, mesoscopic sample are investigated using ultrasonic waves, and compared with theoretical predictions based on circular Gaussian statistics. The fundamental role of phase in Diffusing Acoustic Wave Spectroscopy is revealed, and phase statistics are also shown to provide a sensitive and accurate way to probe scatterer motions at both short and long time scales.Comment: 4 pages, 4 figures, submitted to Physical Review Letter

FACT - Long-term stability and observations during strong Moon light

The First G-APD Cherenkov Telescope (FACT) is the first Cherenkov telescope equipped with a camera made of silicon photon detectors (G-APD aka. SiPM). Since October 2011, it is regularly taking data on the Canary Island of La Palma. G-APDs are ideal detectors for Cherenkov telescopes as they are robust and stable. Furthermore, the insensitivity of G-APDs towards strong ambient light allows to conduct observations during bright Moon and twilight. This gain in observation time is essential for the long-term monitoring of bright TeV blazars. During the commissioning phase, hundreds of hours of data (including data from the the Crab Nebula) were taken in order to understand the performance and sensitivity of the instrument. The data cover a wide range of observation conditions including different weather conditions, different zenith angles and different light conditions (ranging from dark night to direct full Moon). We use a new parmetrisation of the Moon light background to enhance our scheduling and to monitor the atmosphere. With the data from 1.5 years, the long-term stability and the performance of the camera during Moon light is studied and compared to that achieved with photomultiplier tubes so far.Comment: 3 pages, 3 figures, FACT Contribution to the 33rd International Cosmic Ray Conference (ICRC), Rio de Janeir

FACT - How stable are the silicon photon detectors?

The First G-APD Cherenkov telescope (FACT) is the first telescope using silicon photon detectors (G-APD aka. SiPM). The use of Silicon devices promise a higher photon detection efficiency, more robustness and higher precision than photo-multiplier tubes. Since the properties of G-APDs depend on auxiliary parameters like temperature, a feedback system adapting the applied voltage accordingly is mandatory. In this presentation, the feedback system, developed and in operation for FACT, is presented. Using the extraction of a single photon-equivalent (pe) spectrum as a reference, it can be proven that the sensors can be operated with very high precision. The extraction of the single-pe, its spectrum up to 10\,pe, its properties and their precision, as well as their long-term behavior during operation are discussed. As a by product a single pulse template is obtained. It is shown that with the presented method, an additional external calibration device can be omitted. The presented method is essential for the application of G-APDs in future projects in Cherenkov astronomy and is supposed to result in a more stable and precise operation than possible with photo-multiplier tubes

FACT - Long-term Monitoring of Bright TeV-Blazars

Since October 2011, the First G-APD Cherenkov Telescope (FACT) is operated successfully on the Canary Island of La Palma. Apart from the proof of principle for the use of G-APDs in Cherenkov telescopes, the major goal of the project is the dedicated long-term monitoring of a small sample of bright TeV blazars. The unique properties of G-APDs permit stable observations also during strong moon light. Thus a superior sampling density is provided on time scales at which the blazar variability amplitudes are expected to be largest, as exemplified by the spectacular variations of Mrk 501 observed in June 2012. While still in commissioning, FACT monitored bright blazars like Mrk 421 and Mrk 501 during the past 1.5 years so far. Preliminary results including the Mrk 501 flare from June 2012 will be presented.Comment: 4 pages, 4 figures, presented at the 33rd ICRC (2013