Synthesis, structure, and antimicrobial activity of (carboxyalkyl)dimethylsulfonium halides

© 2017, Pleiades Publishing, Ltd. Reactions of a series of ω-halocarboxylic acids (2-bromo-, 2-chloroethanoic, 3-bromo- and 3-chloropropanoic) with dimethyl sulfide resulted in the formation of stable (carboxylalkyl)dimethylsulfonium bromides and chlorides. Composition and structure of the salts obtained were established by a complex of chemical, physical and physicochemical methods. The sulfonium salts obtained showed high antibacterial and antimycotic activities with respect to the pathogenic microflora of humans and animals

Synthesis and biological evaluation of novel carboxylate phosphabetaines derivatives with long alkyl chains

© 2016 Taylor & Francis Group, LLC.The purpose of the present study was to investigate the antibacterial activity of novel alkyl esters of carboxylate phosphabetaine: β-(carboxyalkyl)ethyltributylphosphonium bromides 4–8. The in vitro microbiological activity of the synthesized phosphonium bromides against gram-positive, gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. Microbiological results indicate the synthesized phosphonium salts possess a broad spectrum of activity against the testedmicroorganisms. Every newly synthesized compound was characterized by elemental analyses, IR, 1H NMR, 31P NMR spectral studies

Synthesis, structure, and biological activity of dicarboxylate phosphabetaines

© 2016 Taylor & Francis Group, LLC.New stable dicarboxylate phosphabetaines were synthesized by the phosphorylation of a series of unsaturated carboxylic acids. Interaction of 3-(diphenylphosphonio)propionic acid with unsaturated monocarboxylic acids leads to the formation of stable dicarboxylate phosphabetaines 1–7. The structure of the isolated compounds was determined by IR and NMR spectroscopy, X-ray single crystal diffraction studies, and elemental analysis. Their thermal stability was studied by simultaneous thermogravimetry and differential scanning calorimetry. All of the synthesized compoundswere tested for their antibacterial and anti-Candida activity

Synthesis and structure of novel phosphorylated azomethines

© 2016 Taylor & Francis Group, LLC.The condensation of do-, hexa-, octadecan-1-amines with bromo- and nitrobenzaldehydes yielded a series of Schiff bases in good yields. Subsequent reaction of these compounds with dioctylphosphine oxide yielded phosphorylated azomethines and some were characterized using X-ray crystallography. The structure of the isolated compounds was determined by IR and NMR spectroscopy, elemental analysis, and their thermal stability was studied by simultaneous thermogravimetry and differential scanning calorimetry. All of the synthesized compounds were tested for their antibacterial and anti-Candida activity. A number of the compounds exhibited antimicrobial activity comparable to that of the commercially available drugs, ciprofloxacin and clotrimazole

Synthesis, structure, and antimicrobial activity of (carboxyalkyl)dimethylsulfonium halides

© 2017, Pleiades Publishing, Ltd. Reactions of a series of ω-halocarboxylic acids (2-bromo-, 2-chloroethanoic, 3-bromo- and 3-chloropropanoic) with dimethyl sulfide resulted in the formation of stable (carboxylalkyl)dimethylsulfonium bromides and chlorides. Composition and structure of the salts obtained were established by a complex of chemical, physical and physicochemical methods. The sulfonium salts obtained showed high antibacterial and antimycotic activities with respect to the pathogenic microflora of humans and animals

Synthesis, structure, and antimicrobial activity of (carboxyalkyl)dimethylsulfonium halides

© 2017, Pleiades Publishing, Ltd. Reactions of a series of ω-halocarboxylic acids (2-bromo-, 2-chloroethanoic, 3-bromo- and 3-chloropropanoic) with dimethyl sulfide resulted in the formation of stable (carboxylalkyl)dimethylsulfonium bromides and chlorides. Composition and structure of the salts obtained were established by a complex of chemical, physical and physicochemical methods. The sulfonium salts obtained showed high antibacterial and antimycotic activities with respect to the pathogenic microflora of humans and animals

Synthesis, structure, and biological activity of dicarboxylate phosphabetaines

© 2016 Taylor & Francis Group, LLC.New stable dicarboxylate phosphabetaines were synthesized by the phosphorylation of a series of unsaturated carboxylic acids. Interaction of 3-(diphenylphosphonio)propionic acid with unsaturated monocarboxylic acids leads to the formation of stable dicarboxylate phosphabetaines 1–7. The structure of the isolated compounds was determined by IR and NMR spectroscopy, X-ray single crystal diffraction studies, and elemental analysis. Their thermal stability was studied by simultaneous thermogravimetry and differential scanning calorimetry. All of the synthesized compoundswere tested for their antibacterial and anti-Candida activity

Synthesis and biological evaluation of novel carboxylate phosphabetaines derivatives with long alkyl chains

© 2016 Taylor & Francis Group, LLC.The purpose of the present study was to investigate the antibacterial activity of novel alkyl esters of carboxylate phosphabetaine: β-(carboxyalkyl)ethyltributylphosphonium bromides 4–8. The in vitro microbiological activity of the synthesized phosphonium bromides against gram-positive, gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. Microbiological results indicate the synthesized phosphonium salts possess a broad spectrum of activity against the testedmicroorganisms. Every newly synthesized compound was characterized by elemental analyses, IR, 1H NMR, 31P NMR spectral studies