Optimization Aspects of Carcinogenesis

Any process in which competing solutions replicate with errors and numbers of their copies depend on their respective fitnesses is the evolutionary optimization process. As during carcinogenesis mutated genomes replicate according to their respective qualities, carcinogenesis obviously qualifies as the evolutionary optimization process and conforms to common mathematical basis. The optimization view accents statistical nature of carcinogenesis proposing that during it the crucial role is actually played by the allocation of trials. Optimal allocation of trials requires reliable schemas' fitnesses estimations which necessitate appropriate, fitness landscape dependent, statistics of population. In the spirit of the applied conceptual framework, features which are known to decrease efficiency of any evolutionary optimization procedure (or inhibit it completely) are anticipated as "therapies" and reviewed. Strict adherence to the evolutionary optimization framework leads us to some counterintuitive implications which are, however, in agreement with recent experimental findings, such as sometimes observed more aggressive and malignant growth of therapy surviving cancer cells

Overlaps after quantum quenches in the sine-Gordon model

We present a numerical computation of overlaps in mass quenches in sine-Gordon quantum field theory using truncated conformal space approach (TCSA). To improve the cut-off dependence of the method, we use a novel running coupling definition which has a general applicability in free boson TCSA. The numerical results are used to confirm the validity of a previously proposed analytical Ansatz for the initial state in the sinh-Gordon quench.Comment: 13 pages, 4 pdf figure

Compatibility of alternative fuels with advanced automotive gas turbine and stirling engines. A literature survey

The application of alternative fuels in advanced automotive gas turbine and Stirling engines is discussed on the basis of a literature survey. These alternative engines are briefly described, and the aspects that will influence fuel selection are identified. Fuel properties and combustion properties are discussed, with consideration given to advanced materials and components. Alternative fuels from petroleum, coal, oil shale, alcohol, and hydrogen are discussed, and some background is given about the origin and production of these fuels. Fuel requirements for automotive gas turbine and Stirling engines are developed, and the need for certain reseach efforts is discussed. Future research efforts planned at Lewis are described

Creating temperature dependent Ni-MH battery models for low power mobile devices

In this paper the methodology and the results of creating temperature dependent battery models for ambient intelligence applications is presented. First the measurement technology and the model generation process is presented in details, and then the characteristic features of the models are discussed.Comment: Submitted on behalf of TIMA Editions (http://irevues.inist.fr/tima-editions

Initial states in integrable quantum field theory quenches from an integral equation hierarchy

We consider the problem of determining the initial state of integrable quantum field theory quenches in terms of the post-quench eigenstates. The corresponding overlaps are a fundamental input to most exact methods to treat integrable quantum quenches. We construct and examine an infinite integral equation hierarchy based on the form factor bootstrap, proposed earlier as a set of conditions deter- mining the overlaps. Using quenches of the mass and interaction in Sinh-Gordon theory as a concrete example, we present theoretical arguments that the state has the squeezed coherent form expected for integrable quenches, and supporting an Ansatz for the solution of the hierarchy. Moreover we also develop an iterative method to solve numerically the lowest equation of the hierarchy. The iterative solution along with extensive numerical checks performed using the next equation of the hierarchy provide a strong numerical evidence that the proposed Ansatz gives a very good approximation for the solution.Comment: 36 pages, pdflatex file, 11 pdf figures. v2: revised version, accepted for publicatio

Major loop reconstruction from switching of individual particles

Major hysteresis loops of groups of isolated 60 mm square garnet particles of a regular two-dimensional array, have been measured magnetooptically. Individual loops for each particle were measured, and the statistics of the distribution of coercivities and interaction fields was determined. It is shown that from the measured coercivity distribution and calculated magnetostatic interaction fields the major hysteresis loop can be reconstructed. The switching sequence, and the major loop of an assembly of 535 particles were calculated numerically for two cases: first, when calculating the magnetostatic interaction, the 25 particles were assumed to be isolated; second, the major loop of the same 25 particles, embedded into a 939 square, was reconstructed taking into account the interactions among all 81 particles. The numerically simulated major hysteresis loops agree very well with the measured loops, demonstrating the reliability of numerical modeling