Outcomes of the “BRCA Quality Improvement Dissemination Program”: An Initiative to Improve Patient Receipt of Cancer Genetics Services at Five Health Systems

OBJECTIVE: A quality improvement initiative (QII) was conducted with five community-based health systems\u27 oncology care centers (sites A-E). The QII aimed to increase referrals, genetic counseling (GC), and germline genetic testing (GT) for patients with ovarian cancer (OC) and triple-negative breast cancer (TNBC). METHODS: QII activities occurred at sites over several years, all concluding by December 2020. Medical records of patients with OC and TNBC were reviewed, and rates of referral, GC, and GT of patients diagnosed during the 2 years before the QII were compared to those diagnosed during the QII. Outcomes were analyzed using descriptive statistics, two-sample t-test, chi-squared/Fisher\u27s exact test, and logistic regression. RESULTS: For patients with OC, improvement was observed in the rate of referral (from 70% to 79%), GC (from 44% to 61%), GT (from 54% to 62%) and decreased time from diagnosis to GC and GT. For patients with TNBC, increased rates of referral (from 90% to 92%), GC (from 68% to 72%) and GT (81% to 86%) were observed. Effective interventions streamlined GC scheduling and standardized referral processes. CONCLUSION: A multi-year QII increased patient referral and uptake of recommended genetics services across five unique community-based oncology care settings

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Tomographic imaging of severely disrupted fuel assemblies tested in TREAT

A series of CT codes is under development in the Reactor Analysis and Safety Division of Argonne National Laboratory for use as a post-test examination tool to analyze segments of the final fuel-bundle configuration of TREAT tests. This paper presents the results of CT analysis for fuel assemblies using neutron radiography. Fuel relocation following overpower transients in the TREAT reactor is examined for sections of the assemblies, and results are compared to metallographic sections. Further improvements are expected to increase the use and reliability of CT analysis as a standard post-test examination tool

Post-failure material movement in the PFR/TREAT experiments

In the PFR/TREAT experiments the fast neutron hodoscope has provided experimental data on post-failure material movement during Transient Overpower and Transient Under-Cooled Overpower events. Analyses of selected experiments have been done, using SIMMER-II and SAS4A, to validate these codes. Full results of these analyses are presented in the paper. The general conclusion that can be drawn from the analyses that have been made so far is that the hodoscope is providing data which has appropriate resolution in time and space and that the computer models which are being used by the USDOE and the UKAEA provide good representations of fuel redistribution