4,968 research outputs found
Investigation of a liquid-fed water resistojet plume
Measurements of mass flux and flow angle were taken throughout the forward flow region of the exhaust of a liquid-fed water resistojet using a quartz crystal microbalance (QCM). The resistojet operated at a mass flow rate of 0.1 g/s with a power input of 330 Watts. Measured values were compared to theoretical predictions obtained by employing a source flow approximation. Excellent agreement between predicted and measured mass flux values was attained; however, this agreement was highly dependent on knowledge of nozzle flow conditions. Measurements of the temperature at which the exhaust condensed on the QCM were obtained as a function of incident mass flux
Speckle Interferometry of Metal-Poor Stars in the Solar Neighborhood. I
We report the results of speckle-interferometric observations of 109 high
proper-motion metal-poor stars made with the 6-m telescope of the Special
Astrophysical Observatory of the Russian Academy of Sciences. We resolve eight
objects -- G102-20, G191-55, BD+19~1185A, G89-14, G87-45, G87-47,
G111-38, and G114-25 -- into individual components and we are the first to
astrometrically resolve seven of these stars. New resolved systems included two
triple (G111-38, G87-47) and one quadruple (G89-14) star. The ratio of
single-to-binary-to-triple-to-quadruple systems among the stars of our sample
is equal to 71:28:6:1.Comment: 8 pages, 4 figures, accepted to Astrophysical Bulleti
Effects of candesartan versus amlodipine on capillary rarefaction, pulse wave velocity, and central blood pressure in patients with essential hypertension
Background: A reduction in the density of capillaries (rarefaction) is known to occur in many tissues in patients with essential hypertension and play a role in increasing Blood Pressure (BP). The aim of this trial was to assess in a randomized, double blind, design the effects of treatment of hypertension with candesartan versus amlodipine on microvascular rarefaction and other indices of vascular function.
Methods: We recruited twenty-two individuals with mild-to-moderate hypertension. After a 2-week placebo run-in period, patients who remained hypertensive (≥140/90 mmHg) were randomized to 8-weeks treatment with Candesartan tablets 8mg daily (with forced titration to 16mg) or Amlodipine tablets 5mg daily (with forced titration to 10mg). The capillary microcirculation was studied using CapiScope system CAM1. Pulse wave velocity, central BP and aortic Augmentation Index were also measured.
Results: We observed significant reductions in brachial BP, and central BP after 4 and 8 weeks treatment with either candesartan or amlodipine but there was no significant effect on basal (functional) or maximal (structural) capillary densities, or pulse wave velocity.
Conclusion: Eight weeks treatment of hypertension with either amlodipine or candesartan significantly reduced brachial and central BP but was not sufficient to induce a regression in functional or structural microvascular abnormalities
Can the Experience of Participatory Development Help Think Critically about ‘Patient and Public Involvement’ in UK Healthcare?
The expansion of spaces for ‘patient and public involvement’ (PPI) in health systems in the UK is a relatively recent phenomenon, and yet ‘participation’ as a principle for planned interventions in international development is well established as a field of practice and controversy. Development workers and scholars have passed through moments of enchantment and disenchantment with the idea that the true source of innovation, expertise and workable (and sustainable) solutions is to be found not in the professionals but in communities of experience. Making ‘local knowledge’ the basis of interventions has proved unexpectedly problematic. How could incommensurable forms of knowing, across steep gradients of power be bridged? This article describes a decade-long experiment in participatory development in a remote Adivasi (tribal) region of western India in order to suggest the relevance of this experience for the very different context of PPI in healthcare settings. In particular, it highlights some general points about knowledge practices at the interface, and the human tendency to adjust, mirror, mimic, loop and in other ways make the ‘patient-professional’ interface itself hard to navigate. The article suggests that self-reflective insight into these social processes is necessary for effective ‘engagement’ by professional and lay actors alike
Computational lens for the near field
A method is presented to reconstruct the structure of a scattering object from data acquired with a photon scanning tunneling microscope. The data may be understood to form a Gabor type near-field hologram and are obtained at a distance from the sample where the field is defocused and normally uninterpretable. Object structure is obtained by the solution of the inverse scattering problem within the accuracy of a perturbative, two-dimensional model of the object
A Comparison of the Chemical Evolutionary Histories of the Galactic Thin Disk and Thick Disk Stellar Populations
We have studied 23 long-lived G dwarfs that belong to the thin disk and thick
disk stellar populations. Abundances have been derived for 24 elements: O, Na,
Mg, Al, Si, Ca, Ti, Sc, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Sr, Y, Zr, Ba, La, Ce,
Nd, and Eu. We find that the behavior of [alpha/Fe] and [Eu/Fe] vs. [Fe/H] are
quite different for the two populations. As has long been known, the thin disk
O, Mg, Si, Ca, and Ti ratios are enhanced relative to iron at the lowest
metallicities, and decline toward solar values as [Fe/H] rises above -1.0. For
the thick disk, the decline in [alpha/Fe] and [Eu/Fe] does not begin at [Fe/H]
= -1.0, but at -0.4. Other elements share this behavior, including Sc, Co, and
Zn, suggesting that at least in the chemical enrichment history of the thick
disk, these elements were manufactured in similar-mass stars. Combining our
results for the oldest and longest-lived stars with prior work, we find clear
signs for an independent origin for the Galactic thick disk. (Abridged)Comment: 48 pages and 20 figures, accepted for publication in the Astronomical
Journa
Line Broadening in Field Metal-poor Red Giant and Red Horizontal Branch Stars
We report 349 radial velocities for 45 metal-poor field red giant and red
horizontal branch stars. We have have identified one new spectroscopic binary,
HD 4306, and one possible such system, HD 184711. We also report 57 radial
velocities for 11 of the 91 stars reported on previously by Carney et al.
(2003). As was found in the previous study, radial velocity "jitter" is present
in many of the most luminous stars. Excluding stars showing spectroscopic
binary orbital motion, all 7 of the red giants with M(V) <= -2.0 display
jitter, as well as 3 of the 14 stars with -2.0 <= M(V) <= -1.4. We have also
measured line broadening in all of the new spectra, using synthetic spectra as
templates. The most luminous red giants show significant line broadening, as do
many of the red horizontal branch stars, and we discuss briefly possible
causes.Comment: To appear in the Astronomical Journa
The Multiple Origin of Blue Straggler Stars: Theory vs. Observations
In this chapter we review the various suggested channels for the formation
and evolution of blue straggler stars (BSSs) in different environments and
their observational predictions. These include mass transfer during binary
stellar evolution - case A/B/C and D (wind Roche-lobe overflow) mass transfer,
stellar collisions during single and binary encounters in dense stellar
cluster, and coupled dynamical and stellar evolution of triple systems. We also
explore the importance of the BSS and binary dynamics in stellar clusters. We
review the various observed properties of BSSs in different environments (halo
and bulge BSSs, BSSs in globular clusters and BSSs in old open clusters), and
compare the current observations with the theoretical predictions for BSS
formation. We try to constrain the likely progenitors and processes that play a
role in the formation of BSSs and their evolution. We find that multiple
channels of BSS formation are likely to take part in producing the observed
BSSs, and we point out the strengths and weaknesses of each the formation
channel in respect to the observational constraints. Finally we point out
directions to further explore the origin of BSS, and highlight eclipsing binary
BSSs as important observational tool.Comment: Chapter 11, in Ecology of Blue Straggler Stars, H.M.J. Boffin, G.
Carraro & G. Beccari (Eds), Astrophysics and Space Science Library, Springe
Mentoring faculty online: a literature review and recommendations for web-based programs
Teaching-focused faculty mentorship programs can expose instructors to new ideas, as well as opportunities for critical self-reflection, professional growth, and network building. In this literature review, we synthesize the research on teaching-focused faculty mentorship programs that have been facilitated at institutions of higher education through online or blended modalities. We identify key trends in the reported outcomes of these programs, as well as aspects of program design and implementation that might enable or impede program success. Finally, we provide eight recommendations to help guide the implementation of online and blended faculty mentorship programs
Effects and mechanisms of action of sildenafil citrate in human chorionic arteries
Objectives
Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for premature labor. Its effects in the feto-placental circulation are not known. Our objectives were to determine whether phosphodiesterase-5 is present in the human feto-placental circulation, and to characterize the effects and mechanisms of action of sildenafil citrate in this circulation.
Study Design
Ex vivo human chorionic plate arterial rings were used in all experiments. The presence of phosphodiesterase-5 in the feto-placental circulation was determined by western blotting and immunohistochemical staining. In a subsequent series of pharmacologic studies, the effects of sildenafil citrate in pre-constricted chorionic plate arterial rings were determined. Additional studies examined the role of cGMP and nitric oxide in mediating the effects of sildenafil.
Results
Phosphodiesterase-5 mRNA and protein was demonstrated in human chorionic plate arteries. Immunohistochemistry demonstrated phosphodiesterase-5 within the arterial muscle layer. Sildenafil citrate produced dose dependent vasodilatation at concentrations at and greater than 10 nM. Both the direct cGMP inhibitor methylene blue and the cGMP-dependent protein kinase inhibitor Rp-8-Br-PET-cGMPS significantly attenuated the vasodilation produced by sildenafil citrate. Inhibition of NO production with L-NAME did not attenuate the vasodilator effects of sildenafil. In contrast, sildenafil citrate significantly enhanced the vasodilation produced by the NO donor sodium nitroprusside.
Conclusion
Phosphodiesterase-5 is present in the feto-placental circulation. Sildenafil citrate vasodilates the feto-placental circulation via a cGMP dependent mechanism involving increased responsiveness to NO
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