Bail-In from an Insolvency Law Perspective

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Abstract. Sex hormone-binding globulin or ABP/SHBG is an extracellular androgen and oestrogen carrier. In the rat, ABP/SHBG is secreted by Sertoli cells of the testis and is thought to regulate androgen bioavailability in the male reproductive tract. During ontogenesis, ABP/SHBG is expressed in many mesoderm-derived tissues, including interdigital mesenchyme of the developing autopodium. Shbg is thus a candidate for Hd, comprising autopodium (hand and foot) reduction and male sterility resulting from spermatogenesis impairment. Moreover, linkage mapping of Hd revealed that an intragenic marker for Shbg, D10Wox12, was nonrecombinant with Hd. Sequencing of the entire coding sequence of Shbg failed to identify any variation in hypodactylous animals, distinct from two control strains. However, RT-PCR analysis revealed a significantly higher level of the Shbg transcript in hypodactylous rats compared to SHR controls. Whether Shbg expression is upregulated due to a cis-acting mutation in regulatory elements of the Shbg gene or it is a secondary result of spermatogenesis failure remains to be determined. Sex hormone-binding globulin, or alternatively androgen-binding protein (ABP/SHBG) is an extracellular carrier glycoprotein that binds androgens and oestrogens (more particularly testosterone, dihydrotestosterone and oestradiol) with high affinity The expression pattern of ABP/SHBG is also species-dependent. In rodents, ABP/SHBG is produced by Sertoli cells of the testi