The North American Journals of Prince Maximilian of Wied, volume 3, September 1833-August 1834

Review of: "The North American Journals of Prince Maximilian of Wied, volume 3, September 1833-August 1834," edited by Stephen S. Witte and Marsha V. Gallagher and translated by Dieter Karch

The North American Journals of Prince Maximilian of Wied, volume 3, September 1833-August 1834

Review of: "The North American Journals of Prince Maximilian of Wied, volume 3, September 1833-August 1834," edited by Stephen S. Witte and Marsha V. Gallagher and translated by Dieter Karch

Social pedagogy as relational attachment practice

The utility of social pedagogy as an approach to building resiliency and developing positive relationships with children and youth is currently underdeveloped in North America. However, there are signs of growth in this field. For example, one youth project in British Columbia, Canada, employs relationship building, collaboration and creativity in terms of music- or art-based community interventions as part of its programme. The findings from a recent evaluation report on this youth project will be used to explore the potential for a social pedagogical approach being deployed more widely, and possibly more effectively, than current youth-focused practice. Specifically, the importance of relational practice, underpinned by aspects of attachment theory will be used to explore the utility of social pedagogical practices and examine the possibility of its development within a number of professional contexts

Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects

Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones. It remains unclear whether these changes in biliary cholesterol excretion are associated with changes in cholesterol synthesis and bile acid synthesis. We therefore studied the activities of rate-limiting enzymes of cholesterol synthesis and bile acid synthesis, 3-hydroxy-3-methyl-glutarylcoenzyme A reductase and cholesterol 7alpha-hydroxylase, respectively, in normal subjects during UDCA feeding. Methods: UDCA was given to 8 healthy volunteers ( 5 men, 3 women; age 24-44 years) in a single dose of 10-15 mg/kg body weight for 40 days. Before and during ( days 3, 5, 10, 20, 30 and 40) UDCA treatment, urinary excretion of mevalonic acid and serum concentrations of 7alpha-hydroxy-4-cholesten-3-one (7alpha-HCO) were determined as markers of cholesterol and bile acid synthesis, respectively. The Wilcoxon signed rank test and Spearman's rank correlation coefficient were used for statistical analysis. Results: Cholesterol synthesis and serum lipid concentrations remained unchanged during UDCA treatment for 40 days. However, synthesis of bile acids increased during long-term treatment with UDCA as reflected by an increase in 7alpha-HCO serum concentrations from 39.7 +/- 21.3 ng/ml (median 32.8 ng/ml) before treatment to 64.0 +/- 30.4 ng/ml (median 77.5 ng/ml) at days 30-40 of UDCA treatment ( p < 0.05). Conclusions: UDCA treatment does not affect cholesterol synthesis in the liver, but does increase bile acid synthesis after prolonged treatment. This may represent a compensatory change following decreased absorption of endogenous bile acids as observed with UDCA therapy

Performance of Port Facilities During the Northridge Earthquake

During the January 17, 1994, Northridge earthquake, two of the Port of Los Angeles\u27 facilities called Berths 121-126 and Pier 300 sustained moderate damage. Lateral displacement of dikes up to five inches and liquefaction of hydraulic fills were observed. Several geotechnical analyses from simplified SPT -based method to sophisticated fully-coupled analyses are presented. Observed lateral displacements are predicted reasonably well by the fully-coupled analysis procedure and an intermediate analysis procedure which incorporates some results from a fully-coupled analysis in to a simplified Newmark-type deformation analysis. The potential for higher pore pressure generation underneath the dike compared to a level ground is also discussed

Food habits of imperiled Plains Topminnow and diet overlap with invasive Western Mosquitofish in the Central Great Plains

Plains Topminnow (Fundulus sciadicus) populations have experienced large declines throughout the Central Great Plains, with Western Mosquitofish (Gambusia affinis) introductions suggested as a contributing factor. There are limited studies identifying the food habits of Plains Topminnow and the trophic interactions with Western Mosquitofish. This study sought to determine if a diet overlap exists between the Plains Topminnow and the introduced Western Mosquitofish by identifying the feeding habits of both species. We analyzed diets from lentic and lotic populations of Plains Topminnow captured in August and found lentic topminnows employed a generalist diet while lotic topminnow selected for gastropods. Additionally, Western Mosquitofish diets from regionally proximate lotic and lentic populations also displayed a generalist diet consisting of benthic, littoral and terrestrial macroinvertebrates. The two species did not show overlapping diets based on Schoener’s Index. Therefore we suggest the introduced Western Mosquitofish do not likely impact Plains Topminnow populations through food resource competition

A noninvasive method for quantifying cerebral blood flow by hybrid PET/MRI

Although PET with 15O-water is the gold standard for imaging cerebral blood flow (CBF), quantification requires measuring the arterial input function (AIF), which is an invasive and noisy procedure. To circumvent this problem, we propose a noninvasive PET/MRI approach that eliminates the need to measure AIF by using global CBF determined by phase-contrast (PC) MRI as a reference region. This approach not only is noninvasive but also involves no additional imaging time, because PC MRI and 15O-water PET are acquired simultaneously. The purpose of this study was to test the accuracy of this hybrid method in an animal model in which AIF was measured directly and CBF was varied by changing the arterial CO2 tension. Methods: PET and MRI data were simultaneously acquired in juvenile pigs at hypocapnia (n 5 5), normocapnia (n 5 5), and hypercapnia (n 5 4). CBF was measured by the MRI reference method and by PET alone using an MRI-compatible blood sampling system to measure AIF. Results: Global CBF estimates from PC MRI and 15O-water PET agreed well, with a correlation coefficient of 0.9 and a slope of 0.88. Strong positive correlations (R2 . 0.96) were also found between regional CBF generated by the PET-only and the MRI-reference methods. Conclusion: These findings demonstrate the accuracy of this hybrid PET/MRI approach, which might prove useful in patients for whom obtaining accurate CBF measurements is challenging