41 research outputs found
Listeria Monocytogenes in a Young Patient with Non Hodgkin's Lymphoma: Case Report
Listeria monocytogenes is an intracellular food-borne pathogen, widely distributed in the environment, which rarely causes clinical infection in healthy people, but may cause severe disease in immunocompromised patients. A case of listeriosis is certified in an immunocompromised patient, thus confirming this microorganism to be an opportunistic human pathogen
Enhanced follicular delivery of finasteride to human scalp skin using heat and chemical penetration enhancers
© The Author(s) 2020. This article is an open access publication. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Purpose The aim of this work was to evaluate whether improved topical delivery of finasteride, focussed to the hair follicles of human scalp skin could be achieved with application of short durations of heat and use of specific chemical penetration enhancers. Methods Franz cell experiments with human scalp skin were performed with a range of chemical penetration enhancers at 32°C and 45°C to simulate normal and heated conditions. Selected chemical penetration enhancers were taken forward for finite dose Franz cell studies which examined the effect of heat produced by a prototype external heating system that supplied either 20 or 30 min of additional heat over both a 24 h and a 1 h time period. Results Short durations of externally applied heat significantly increased finasteride penetration into human scalp skin after 24 h. Analysis of drug distribution in the skin after 1 h and 24 h indicated that both heat and chemical penetration enhancer selection influenced drug delivery to the hair follicles. Conclusion The use of short durations of heat in combination with specific chemical penetration enhancers was able to increase the delivery of finasteride to human scalp skin and provide focussed drug delivery to the hair follicles.Peer reviewe
Proteomic map of peripheral blood mononuclear cells
In the field of proteomics extensive efforts have been focused on the knowledge of proteins
expressed by different cell types. In particular, enormous progress has been done in the
characterization of blood cellular components. In this work, we have established a public
2-DE database for human peripheral blood mononuclear cells (PBMCs) proteins. Two
hundred and forty-six spots corresponding to 174 different proteins have been identified
on 2-DE gels from PBMCs isolated from six healthy individuals. All the identified proteins
have been classified in thirteen categories on the basis of their differential functions or
cellular localization and annotated at the http://physiology.unile.it/proteomics. The role of
several proteins has been discussed in relation to their biological function. We intend to
show the potentiality of PBMCs to investigate the proteomics changes possibly associated
with a large number of pathologies such as autoimmune, neurodegenerative and cancer
diseases
Simultaneous ventral tunical grafting and three pieces inflatable penile prosthesis implantation
6reservedmixedCapece, M.; Chiriacò, G.; Ralph, D.; Liguori, G.; Trombetta, C.; Garaffa, G.Capece, M.; Chiriacò, G.; Ralph, D.; Liguori, G.; Trombetta, C.; Garaffa, G
Listeria Monocytogenes in a Young Patient with Non Hodgkin's Lymphoma: Case Report
Listeria monocytogenes is an intracellular food-borne pathogen, widely distributed in the environment, which rarely causes clinical infection in healthy people, but may cause severe disease in immunocompromised patients. A case of listeriosis is certified in an immunocompromised patient, thus confirming this microorganism to be an opportunistic human pathogen