Synthesis, spectral characterization and bioactivity evaluation of sulfonamide derivatives of p-nitrobenzene sulfonylchloride

1375-1383A simple and convenient method for the synthesis of biologically active sulfonamide derivatives of p-nitrobenzene sulfonylchloride has been achieved. All the title compounds have been characterized by spectral and elemental analysis. They have been further screened in vitro for their antibacterial and antifungal activities. All the compounds show good to moderate activity against both bacteria and fungi when compared with standard bactericide, Streptomycin and fungicide, Nystatin

Sulfonylurea derivatives of tolbutamide analogues: Synthesis and evaluation of antimicrobial and antioxidant activities

127-135A series of new sulfonylurea derivatives of tolbutamide analogues have been synthesized in a simple and effective way in high yields to explore the possibilities of some altered biological actions such as antibacterial, antifungal and antioxidant activities (DPPH, H2O2 and IC50 values). Structures of these compounds have been well established by IR, 1H and 13C NMR, mass spectra and elemental analysis. Among the compounds 9c and 9j show promising antimicrobial activity. Compounds 9a, 9j and 9d exhibit good antioxidant activity with lowest IC50 values and close to the standard drug, ascorbic acid. Biological data reveals that sulfonylurea derivatives show good antioxidant activity rather than antimicrobial activity

Synthesis and bioactivity evaluation of new phenyl <i>N,N′-</i>phenylphosphorodiamidates

<p></p> <p>A series of new biologically active phenyl N,N<b>^′-</b>phenyl phosphorodiamidates were synthesized by reacting phenyl phenylphosphoramidochoridate with various amines. All the newly synthesized compounds <b>3a-j</b> were tested for their antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide (H₂O₂) and nitric oxide (NO) methods. In all the three methods the compounds <b>3c</b> (phenyl N-(6-methoxy-1,3-benzothiazol-2-yl)-N′-phenyl-phosphorodiamidate) and <b>3e</b> (phenyl N-(5-ethyl-1,3,4-thiadiazol-2-yl)-N′-phenylphosphorodiamidate) showed good radical scavenging activity.</p