Gluino production in ultrarelativistic heavy ion collisions and nuclear shadowing

In this article we investigate the influence of nuclear effects in the production of gluinos in nuclear collisions at the LHC, and estimate the transverse momentum dependence of the nuclear ratios $R_{pA} = {\frac{d\sigma (pA)}{dy d^2 p_T}} / A {\frac{d\sigma (pp)}{dy d^2 p_T}}$ and $R_{AA} = {\frac{d\sigma (AA)}{dy d^2 p_T}} / A^2 {\frac{d\sigma (pp)}{dy d^2 p_T}}$. We demonstrate that depending on the magnitude of the nuclear effects, the production of gluinos could be enhanced, compared to proton-proton collisions. The study of these observables can be useful to determine the magnitude of the shadowing and antishadowing effects in the nuclear gluon distribution. Moreover, we test different SPS scenarios, corresponding to different soft SUSY breaking mechanisms, and find that the nuclear ratios are strongly dependent on that choice.Comment: 7 pages, 5 figures; results and discussions changed/added. Accepted for publication in Physical Review

Cultivo orgânico de milho verde em sistema plantio direto na palhada de diferentes espécies de plantas de cobertura do solo.

Foram avaliadas, em Seropédica, RJ (Baixada Fluminense), diferentes espécies botânicas, em cultivos solteiros e consorciados, antecedendo o plantio direto de milho verde submetido ao manejo orgânico. Adotou-se delineamento de blocos ao acaso com quatro repetições. Os tratamentos constaram de cultivos solteiros de crotalária ? Crotalaria juncea (C), girassol ? Helianthus annuus (G), sorgo ? Sorghum bicolor (S) e mamona ? Ricinus communis (M); dos consórcios: C + G, C + S, C + M, C + G + S, C + G + M, C + S + M e C + G + S + M; além do pousio, representado pelas parcelas mantidas cobertas com a vegetação espontânea. Na ausência da palhada de crotalária, o milho recebeu adubação suplementar com torta de mamona (2,0 Mg ha-1), 35 dias após a semeadura. Máxima contribuição em biomassa aérea correspondeu ao cultivo solteiro de crotalária. Nos consórcios, a leguminosa produziu mais biomassa do que cada uma das outras espécies e também acumulou maior quantidade de nitrogênio nos tecidos. Em sucessão aos cultivos solteiros das plantas de cobertura do solo e ao pousio, o milho alcançou produtividade maior do que em sucessão aos cultivos consorciados. Os resultados indicaram vantagem do uso da crotalária para o plantio direto do milho, pelo volume de palhada disponibilizada para adubação verde, o que proporcionou rendimento em espigas comercializáveis equivalente ou superior aos tratamentos nos quais o milho foi beneficiado pela adubação orgânica suplementar de cobertura.bitstream/item/42981/1/BOP-46.pd

Salivary molecular spectroscopy : a sustainable, rapid and non-invasive monitoring tool for diabetes mellitus during insulin treatment

Monitoring of blood glucose is an invasive, painful and costly practice in diabetes. Consequently, the search for a more cost-effective (reagent-free), non-invasive and specific diabetes monitoring method is of great interest. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy has been used in diagnosis of several diseases, however, applications in the monitoring of diabetic treatment are just beginning to emerge. Here, we used ATR-FTIR spectroscopy to evaluate saliva of non-diabetic (ND), diabetic (D) and insulin-treated diabetic (D+I) rats to identify potential salivary biomarkers related to glucose monitoring. The spectrum of saliva of ND, D and D+I rats displayed several unique vibrational modes and from these, two vibrational modes were pre-validated as potential diagnostic biomarkers by ROC curve analysis with significant correlation with glycemia. Compared to the ND and D+I rats, classification of D rats was achieved with a sensitivity of 100%, and an average specificity of 93.33% and 100% using bands 1452 cm-1 and 836 cm-1, respectively. Moreover, 1452 cm-1 and 836 cm-1 spectral bands proved to be robust spectral biomarkers and highly correlated with glycemia (R2 of 0.801 and 0.788, P < 0.01, respectively). Both PCA-LDA and HCA classifications achieved an accuracy of 95.2%. Spectral salivary biomarkers discovered using univariate and multivariate analysis may provide a novel robust alternative for diabetes monitoring using a non-invasive and green technology

Plantio direto de berinjela (Solanum melongena), sob manejo orgânico, em solo com cobertura viva permanente de gramínea e leguminosa.

bitstream/CNPAB-2010/34358/1/cot091.pd

Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis

Thyroid hormones (THs) are essential for embryonic brain development but the genetic mechanisms involved in the action of maternal THs (MTHs) are still largely unknown. As the basis for understanding the underlying genetic mechanisms of MTHs regulation we used an established zebrafish monocarboxylic acid transporter 8 (MCT8) knock-down model and characterised the transcriptome in 25hpf zebrafish embryos. Subsequent mapping of differentially expressed genes using Reactome pathway analysis together with in situ expression analysis and immunohistochemistry revealed the genetic networks and cells under MTHs regulation during zebrafish embryogenesis. We found 4,343 differentially expressed genes and the Reactome pathway analysis revealed that TH is involved in 1681 of these pathways. MTHs regulated the expression of core developmental pathways, such as NOTCH and WNT in a cell specific context. The cellular distribution of neural MTH-target genes demonstrated their cell specific action on neural stem cells and differentiated neuron classes. Taken together our data show that MTHs have a role in zebrafish neurogenesis and suggest they may be involved in cross talk between key pathways in neural development. Given that the observed MCT8 zebrafish knockdown phenotype resembles the symptoms in human patients with Allan-Herndon-Dudley syndrome our data open a window into understanding the genetics of this human congenital condition.Portuguese Fundacao para Ciencia e Tecnologia (FCT) [PTDC/EXPL/MARBIO/0430/2013]; CCMAR FCT Plurianual financing [UID/Multi/04326/2013]; FCT [SFRH/BD/111226/2015, SFRH/BD/108842/2015, SFRH/BPD/89889/2012]; FCT-IF Starting Grant [IF/01274/2014]info:eu-repo/semantics/publishedVersio

Ocorrência de insetos-pragas e de seus predadores em diferentes sistemas de produção de soja.

bitstream/item/148546/1/27-ocorrencia.pd

Leaf and Root Extracts from Campomanesia adamantium (Myrtaceae) Promote Apoptotic Death of Leukemic Cells via Activation of Intracellular Calcium and Caspase-3

Phytochemical studies are seeking new alternatives to prevent or treat cancer, including different types of leukemias. Campomanesia adamantium, commonly known as guavira or guabiroba, exhibits pharmacological properties including antioxidant, antimicrobial, and antiproliferative activities. Considering the anticancer potential of this plant species, the aim of this study was to evaluate the antileukemic activity and the chemical composition of aqueous extracts from the leaves (AECL) and roots (AECR) of C. adamantium and their possible mechanisms of action. The extracts were analyzed by LC-DAD-MS, and their constituents were identified based on the UV, MS, and MS/MS data. The AECL and AECR showed different chemical compositions, which were identified as main compounds glycosylated flavonols from AECL and ellagic acid and their derivatives from AECR. The cytotoxicity promoted by these extracts were evaluated using human peripheral blood mononuclear cells and Jurkat leukemic cell line. The cell death profile was evaluated using annexin-V-FITC and propidium iodide labeling. Changes in the mitochondrial membrane potential, the activity of caspases, and intracellular calcium levels were assessed. The cell cycle profile was evaluated using propidium iodide. Both extracts caused concentration-dependent cytotoxicity only in Jurkat cells via late apoptosis. This activity was associated with loss of the mitochondrial membrane potential, activation of caspases-9 and -3, changes in intracellular calcium levels, and cell cycle arrest in S-phase. Therefore, the antileukemic activity of the AECL and AECR is mediated by mitochondrial dysfunction and intracellular messengers, which activate the intrinsic apoptotic pathway. Hence, aqueous extracts of the leaves and roots of C. adamantium show therapeutic potential for use in the prevention and treatment of diseases associated the proliferation of tumor cell.Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Mato Grosso do Sul (FUNDECT)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Instituto Nacional de Pesquisa do Pantanal - INPPFundação de Amparo e Desenvolvimento da Pesquisa FadespFed Univ Grande Dourados, Res Grp Biotechnol & Bioprospecting Appl Metab, Dourados, BrazilUniv Fed São Paulo, Dept Biochem, São Paulo, BrazilUniv Braz Cubas, Fac Pharm, Mogi Das Cruzes, BrazilUniv Mogi das Cruzes, Interdisciplinary Ctr Biochem Invest, Mogi Das Cruzes, BrazilUniv Fed São Paulo, Dept Pharmaceut Sci, São Paulo, BrazilUniv Fed Mato Grosso do Sul, Lab Nat Prod & Mass Spectrometry, Campo Grande, MS, BrazilUniv Fed São Paulo, Dept Biochem, São Paulo, BrazilUniv Fed São Paulo, Dept Pharmaceut Sci, São Paulo, BrazilWeb of Scienc

Análises físico-químicas de vinhos experimentais elaborados no Vale do Submédio São Francisco.

O presente trabalho teve como objetivo realizar análises físico-químicas (acidez total e volátil, teor alcoólico, densidade e pH) para a caracterização de vinhos experimentais varietais elaborados a partir de uvas de Viognier e Petit Verdot, colhidas em vinhedos estabelecidos sobre o porta-enxerto IAC-766 em 2004, no município de Casa Nova-BA