550 research outputs found

    Implementing an inclusive social work curriculum

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    This paper discusses the implementation of an inclusive curriculum in social work education, in response to an Inclusive Curriculum project at the University of South Australia which aimed to develop principles and policies of inclusivity in curriculum within national priorities. The concept of \u27inclusivity\u27 is located within theories of identity, and international developments on inclusive education. We discuss the articulation of ideas on inclusivity in social work education through the \u27personal story\u27 of an individual social work educator\u27s practices within organizational policies and structures. We show how an educator\u27s \u27personal story\u27 is positioned within particular perspectives of knowledge and pedagogy, and influenced by other personal stories that produced a particular response to implementing an inclusive curriculum in social work.<br /

    Growth of Carbon Nanotubes on HfO2 towards Highly Sensitive Nano-Sensors

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    Carbon nanotube (CNT) growth on HfO2 is reported for the first time. The process uses a combination of Ge and Fe nanoparticles and achieves an increase in CNT density from 0.15 to 6.2 mm length/mm2 compared with Fe nanoparticles alone. The synthesized CNTs are assessed by the fabrication of back-gate CNT field-effect transistors with Al source/drain contacts for nano-sensor applications. The devices exhibit excellent p-type behavior with an Ion=Ioff ratio of 105 and a steep sub-threshold slope of 130 mV/dec

    Metal-catalyst-free growth of carbon nanotubes and their application in field-effect transistors

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    The metal-catalyst-free growth of carbon nanotubes (CNTs) using chemical vapor deposition and the application in field-effect transistors (FETs) is demonstrated. The CNT growth process used a 3-nm-thick Ge layer on SiO2 that was subsequently annealed to produce Ge nanoparticles. Raman measurements show the presence of radial breathing mode peaks and the absence of the disorder induced D-band, indicating single walled CNTs with a low defect density. The synthesized CNTs are used to fabricate CNTFETs and the best device has a state-of-the-art on/off current ratio of 3×108 and a steep sub-threshold slope of 110 mV/dec

    A generalizable mechanism of CD24 signalling and its ability to specifically alter the biogenesis of B cell extracellular vesicles

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    CD24 is a variably glycosylated, glycophosphatidylinositol (GPI)-anchored cell surface protein. Its expression is dynamic during cellular differentiation and ligand interaction. While several decades of research have established that CD24 engages in many cell-type specific functions in many cases the ligands of CD24 are unknown, and researchers have relied on the use of antibodies to mimic ligand binding. Furthermore, as a GPI-anchored protein, CD24 must rely on in cis signalling partners, however little has been elucidated on the cell membrane-proximal signalling activities of CD24. Therefore, the work presented in this thesis presents a more comprehensive examination of CD24 expression, and function in multiple cell types, followed by an in-depth analysis in immature B lymphocytes. In B cells, CD24 is known to mediate the induction of apoptosis. To predict in cis and in trans partners of CD24, an analysis of CD24 mRNA expression, and its potential ligands was performed. In some tissues, such as B cells, an association was identified between CD24 and putative ligands, including Siglec-2. In other tissues, no significant associations were identified. Our previous investigation suggested that CD24 is involved in vesicle trafficking, Consistent with this, CD24 surface protein expression was shown to be dynamic within 1 h of Ab stimulation in WEHI-231 immature B cells and in ex vivo primary immature B cells. I found CD24 promotes the generation of plasma membrane-derived microvesicles (MVs). These MVs transported CD24 between cells. MVs also carried a variety of nucleic acid cargo, identified by RNA-Seq, and protein cargo as determined by mass spectrometry and flow cytometry. The incorporation of these cargos into MVs was variably influenced by CD24 stimulation. Overall, these data suggest that MVs generated in response to CD24 play a role in regulating mitochondria, and immune cell activation. Finally, a unifying hypothesis on the function of CD24 is presented herein, proposing its role as a moderating rheostat of cellular signalling rather than a de novo signalling receptor. Together, this work has significantly advanced our understanding of CD24 in B cells, and may provide insight for studies in other cell types or in diseases such as leukemia
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