Domain-mediated interactions for protein subfamily identification

Within a protein family, proteins with the same domain often exhibit different cellular functions, despite the shared evolutionary history and molecular function of the domain. We hypothesized that domain-mediated interactions (DMIs) may categorize a protein family into subfamilies because the diversified functions of a single domain often depend on interacting partners of domains. Here we systematically identified DMI subfamilies, in which proteins share domains with DMI partners, as well as with various functional and physical interaction networks in individual species. In humans, DMI subfamily members are associated with similar diseases, including cancers, and are frequently co-associated with the same diseases. DMI information relates to the functional and evolutionary subdivisions of human kinases. In yeast, DMI subfamilies contain proteins with similar phenotypic outcomes from specific chemical treatments. Therefore, the systematic investigation here provides insights into the diverse functions of subfamilies derived from a protein family with a link-centric approach and suggests a useful resource for annotating the functions and phenotypic outcomes of proteins.11Ysciescopu

Unusual persistence of superconductivity against high magnetic fields in the strongly-correlated iron-chalcogenide film FeTe:Ox_{x}

We report an unusual persistence of superconductivity against high magnetic fields in the iron chalcogenide film FeTe:O$_{x}$ below ~ 2.5 K. Instead of saturating like a mean-field behavior with a single order parameter, the measured low-temperature upper critical field increases progressively, suggesting a large supply of superconducting states accessible via magnetic field or low-energy thermal fluctuations. We demonstrate that superconducting states of finite momenta can be realized within the conventional theory, despite its questionable applicability. Our findings reveal a fundamental characteristic of superconductivity and electronic structure in the strongly-correlated iron-based superconductors.Comment: 10 pages, 3 figure

Detection of an exoplanet around the evolved K giant HD 66141

Aims. We have been carrying out a precise radial velocity (RV) survey for K giants to search for and study the origin of the lowamplitude and long-periodic RV variations. Methods. We present high-resolution RV measurements of the K2 giant HD 66141 from December 2003 to January 2011 using the fiber-fed Bohyunsan Observatory Echelle Spectrograph (BOES) at Bohyunsan Optical Astronomy Observatory (BOAO). Results. We find that the RV measurements for HD 66141 exhibit a periodic variation of 480.5 +/- 0.5 days with a semi-amplitude of 146.2 +/- 2.7 m/s. The Hipparcos photometry and bisector velocity span (BVS) do not show any obvious correlations with RV variations. We find indeed 706.4 +/- 35.0 day variations in equivalent width (EW) measurements of H_alpha line and 703.0 +/- 39.4 day variations in a space-born measurements 1.25{\mu} flux of HD 66141 measured during COBE/DIRBE experiment. We reveal that a mean value of long-period variations is about 705 +/- 53 days and the origin is a rotation period of the star and variability that is caused by surface inhomogeneities. For the 480 day periods of RV variations an orbital motion is the most likely explanation. Assuming a stellar mass of 1.1 +/- 0.1 M_Sun? for HD 66141, we obtain a minimum mass for the planetary companion of 6.0 +/- 0.3 M_Jup with an orbital semi-major axis of 1.2 +/- 0.1 AU and an eccentricity of 0.07 +/- 0.03.Comment: 7 pages, 10 figures, 3 tables, accepted for publisation in Astronomy & Astrophysic

Cross-Layer Peer-to-Peer Track Identification and Optimization Based on Active Networking

P2P applications appear to emerge as ultimate killer applications due to their ability to construct highly dynamic overlay topologies with rapidly-varying and unpredictable traffic dynamics, which can constitute a serious challenge even for significantly over-provisioned IP networks. As a result, ISPs are facing new, severe network management problems that are not guaranteed to be addressed by statically deployed network engineering mechanisms. As a first step to a more complete solution to these problems, this paper proposes a P2P measurement, identification and optimisation architecture, designed to cope with the dynamicity and unpredictability of existing, well-known and future, unknown P2P systems. The purpose of this architecture is to provide to the ISPs an effective and scalable approach to control and optimise the traffic produced by P2P applications in their networks. This can be achieved through a combination of different application and network-level programmable techniques, leading to a crosslayer identification and optimisation process. These techniques can be applied using Active Networking platforms, which are able to quickly and easily deploy architectural components on demand. This flexibility of the optimisation architecture is essential to address the rapid development of new P2P protocols and the variation of known protocols

Birthrates and delay times of Type Ia supernovae

Type Ia supernovae (SNe Ia) play an important role in diverse areas of astrophysics, from the chemical evolution of galaxies to observational cosmology. However, the nature of the progenitors of SNe Ia is still unclear. In this paper, according to a detailed binary population synthesis study, we obtained SN Ia birthrates and delay times from different progenitor models, and compared them with observations. We find that the Galactic SN Ia birthrate from the double-degenerate (DD) model is close to those inferred from observations, while the birthrate from the single-degenerate (SD) model accounts for only about 1/2-2/3 of the observations. If a single starburst is assumed, the distribution of the delay times of SNe Ia from the SD model is a weak bimodality, where the WD + He channel contributes to the SNe Ia with delay times shorter than 100Myr, and the WD + MS and WD + RG channels to those with age longer than 1Gyr.Comment: 11 pages, 2 figures, accepted by Science in China Series G (Dec.30, 2009

Iwasawa Effects in Multi-layer Optics

There are many two-by-two matrices in layer optics. It is shown that they can be formulated in terms of a three-parameter group whose algebraic property is the same as the group of Lorentz transformations in a space with two space-like and one time-like dimensions, or the $Sp(2)$ group which is a standard theoretical tool in optics. Among the interesting mathematical properties of this group, the Iwasawa decomposition drastically simplifies the matrix algebra under certain conditions, and leads to a concise expression for the S-matrix for transmitted and reflected rays. It is shown that the Iwasawa effect can be observed in multi-layer optics, and a sample calculation of the S-matrix is given.Comment: RevTex 10 pages including 1 psfi