Facile control of nanoporosity in Cellulose Acetate using Nickel(II) nitrate additive and water pressure treatment for highly efficient battery gel separators

We succeed in fabricating nearly straight nanopores in cellulose acetate (CA) polymers for use as battery gel separators by utilizing an inorganic hexahydrate (Ni(NO3)2??6H2O) complex and isostatic water pressure treatment. The continuous nanopores are generated when the polymer film is exposed to isostatic water pressure after complexing the nickel(II) nitrate hexahydrate (Ni(NO3)2??6H2O) with the CA. These results can be attributed to the manner in which the polymer chains are weakened because of the plasticization effect of the Ni(NO3)2??6H2O that is incorporated into the CA. Furthermore, we performed extensive molecular dynamics simulation for confirming the interaction between electrolyte and CA separator. The well controlled CA membrane after water pressure treatment enables fabrication of highly reliable cell by utilizing 2032-type coin cell structure. The resulting cell performance exhibits not only the effect of the physical morphology of CA separator, but also the chemical interaction of electrolyte with CA polymer which facilitates the Li-ion in the cell.ope

Intermittent Antibiotic Treatment Accelerated the Development of Colitis in IL-10 Knockout Mice

Many epidemiological studies suggest an association between antibiotic exposure and the development of inflammatory bowel disease [IBD]. However, the majority of these studies are observational and still the question remains, “Does the specific antibiotic administration regimen play a role in the development of colitis?” This study aimed to compare the possible effects of continuous and intermittent antibiotic exposure on the development of colitis using a colitis-susceptible IL-10 knockout [IL-10–/–] mouse model

Three-dimensional modeling of nitrate-N transport in vadose zone: Roles of soil heterogeneity and groundwater flux

Contamination of groundwater from nitrogen fertilizers in agricultural lands is an important environmental and water quality management issue. It is well recognized that in agriculturally intensive areas, fertilizers and pesticides may leach through the vadose zone and eventually reach groundwater. While numerical models are commonly used to simulate fate and transport of agricultural contaminants, few models have considered a controlled field work to investigate the influence of soil heterogeneity and groundwater flow on nitrate-N distribution in both root zone and deep vadose zone. In this work, a numerical model was developed to simulate nitrate-N transport and transformation beneath a center pivot-irrigated corn field on Nebraska Management System Evaluation area over a three-year period. The model was based on a realistic three-dimensional sediment lithology, as well as carefully controlled irrigation and fertilizer application plans. In parallel, a homogeneous soil domain, containing the major sediment type of the site (i.e. sandy loam), was developed to conduct the same water flow and nitrate-N leaching simulations. Simulated nitrate-N concentrations were compared with the monitored nitrate-N concentrations in 10 multilevel sampling wells over a three-year period. Although soil heterogeneity was mainly observed from top soil to 3m below the surface, heterogeneity controlled the spatial distribution of nitrate-N concentration. Soil heterogeneity, however, has minimal impact on the total mass of nitrate-N in the domain. In the deeper saturated zone, short-term variations of nitrate-N concentration correlated with the groundwater level fluctuations

Isochronous Gaussian Sampling: From Inception to Implementation

Gaussian sampling over the integers is a crucial tool in lattice-based cryptography, but has proven over the recent years to be surprisingly challenging to perform in a generic, efficient and provable secure manner. In this work, we present a modular framework for generating discrete Gaussians with arbitrary center and standard deviation. Our framework is extremely simple, and it is precisely this simplicity that allowed us to make it easy to implement, provably secure, portable, efficient, and provably resistant against timing attacks. Our sampler is a good candidate for any trapdoor sampling and it is actually the one that has been recently implemented in the Falcon signature scheme. Our second contribution aims at systematizing the detection of implementation errors in Gaussian samplers. We provide a statistical testing suite for discrete Gaussians called SAGA (Statistically Acceptable GAussian). In a nutshell, our two contributions take a step towards trustable and robust Gaussian sampling real-world implementations

Modeling the release and spreading of permanganate from aerated slow-release oxidants in a laboratory flow tank

Aerated, slow-release oxidants are a relatively new technology for treating contaminated aquifers. A critical need for advancing this technology is developing a reliable method for predicting the radius of influence (ROI) around each drive point. In this work, we report a series of laboratory flow tank experiments and numerical modeling efforts designed to predict the release and spreading of permanganate from aerated oxidant candles (oxidant-wax composites). To mimic the design of the oxidant delivery system used in the field, a double screen was used in a series of flow tank experiments where the oxidant was placed inside the inner screen and air was bubbled upward in the gap between the screens. This airflow pattern creates an airlift pump that causes water and oxidant to be dispersed from the top of the outer screen and drawn in at the bottom. Using this design, we observed that permanganate spreading and ROI increased with aeration and decreased with advection. A coupled bubble flow and transport model was able to successfully reproduce observed results by mimicking the upward shape and spreading of permanganate under various aeration and advection rates

Binding of the vesicle docking protein p115 to the GTPase Rab1b regulates membrane recruitment of the COPI vesicle coat

Membrane recruitment of the COPI vesicle coat is fundamental to its function and contributes to compartment identity in the early secretory pathway. COPI recruitment is triggered by guanine nucleotide exchange activating the Arf1 GTPase, but the key exchange factor, GBF1, is a peripheral membrane component whose membrane association is dependent on another GTPase, Rab1. Inactive Rab GTPases are in a soluble complex with guanine nucleotide dissociation inhibitor (GDI) and activation of Rab GTPases by exchange factors can be enhanced by GDI dissociation factors (GDFs). In the present study, we investigated the vesicle docking protein p115 and it’s binding to the Rab1 isoform Rab1b. Inhibition of p115 expression induced dissociation of Rab1b from Golgi membranes. Rab1b bound the cc2 domain of p115 and p115 lacking this domain failed to recruit Rab1b. Further, p115 inhibition blocked association of the COPI coat with Golgi membranes and this was suppressed by constitutive activation of Rab1b. These findings show p115 enhancement of Rab1b activation leading to COPI recruitment suggesting a connection between the vesicle docking machinery and the vesicle coat complex during the establishment of post-ER compartment identity

Improving the Sweeping Efficiency of Permanganate into Low Permeable Zones To Treat TCE: Experimental Results and Model Development

The residual buildup and treatment of dissolved contaminants in low permeable zones (LPZs) is a particularly challenging issue for injection-based remedial treatments. Our objective was to improve the sweeping efficiency of permanganate into LPZs to treat dissolved-phase TCE. This was accomplished by conducting transport experiments that quantified the ability of xanthan-MnO4− solutions to penetrate and cover (i.e., sweep) an LPZ that was surrounded by transmissive sands. By incorporating the non-Newtonian fluid xanthan with MnO4−, penetration of MnO4− into the LPZ improved dramatically and sweeping efficiency reached 100% in fewer pore volumes. To quantify how xanthan improved TCE removal, we spiked the LPZ and surrounding sands with 14C-lableled TCE and used a multistep flooding procedure that quantified the mass of 14C-TCE oxidized and bypassed during treatment. Results showed that TCE mass removal was 1.4 times greater in experiments where xanthan was employed. Combining xanthan with MnO4− also reduced the mass of TCE in the LPZ that was potentially available for rebound. By coupling a multiple species reactive transport model with the Brinkman equation for non-Newtonian flow, the simulated amount of 14C-TCE oxidized during transport matched experimental results. These observations support the use of xanthan as a means of enhancing MnO4− delivery into LPZs for the treatment of dissolved-phase TCE. Includes Supplementary Data