Mechanical properties of Zr_(57)Nb_5Al_(10)Cu_(15.4)Ni_(12.6) metallic glass matrix particulate composites

To increase the toughness of a metallic glass with the nominal composition Zr_(57)Nb_5Al_(10)Cu_(15.4)Ni_(12.6), it was used as the matrix in particulate composites reinforced with W, WC, Ta, and SiC. The composites were tested in compression and tension experiments. Compressive strain to failure increased by more than 300% compared with the unreinforced Zr_(57)Nb_5Al_(10)Cu_(15.4)Ni_(12.6), and energy to break of the tensile samples increased by more than 50%. The increase in toughness came from the particles restricting shear band propagation, promoting the generation of multiple shear bands and additional fracture surface area. There was direct evidence of viscous flow of the metallic glass matrix within the confines of the shear bands

High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast.

In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule. If the two strands of DNA are not identical, there will be mismatches within the heteroduplex DNA (hetDNA). In wild-type strains, these mismatches are repaired by the mismatch repair (MMR) system, producing a gene conversion event. In strains lacking MMR, the mismatches persist. Most previous studies involving hetDNA formed during mitotic recombination were restricted to one locus. Below, we present a global mapping of hetDNA formed in the MMR-defective mlh1 strain. We find that many recombination events are associated with repair of double-stranded DNA gaps and/or involve Mlh1-independent mismatch repair. Many of our events are not explicable by the simplest form of the double-strand break repair model of recombination

Transient gravitational waves from pulsar post-glitch recoveries

This work explores whether gravitational waves (GWs) from neutron star (NS) mountains can be detected with current 2nd-generation and future 3rd-generation GW detectors. In particular, we focus on a scenario where transient mountains are formed immediately after a NS glitch. In a glitch, a NS's spin frequency abruptly increases and then often exponentially recovers back to, but never quite reaches, the spin frequency prior to the glitch. If the recovery is ascribed to an additional torque due to a transient mountain, we find that GWs from that mountain are marginally-detectable with Advanced LIGO at design sensitivity and is very likely to be detectable for 3rd-generation detectors such as the Einstein Telescope. Using this model, we are able to find analytical expressions for the GW amplitude and its duration in terms of observables.Comment: 16 pages, 3 figures. Small changes made in response to referee comments. Accepted for publication in MNRA

Tail-Heaviness, Asymmetry, and Profitability Forecasting by Quantile Regression

We show that quantile regression is better than ordinary-least-squares (OLS) regression in forecasting profitability for a range of profitability measures following the conventional setup of the accounting literature, including the mean absolute forecast error (MAFE) evaluation criterion. Moreover, we perform both a simulated-data and an archival-data analysis to examine how the forecasting performance of quantile regression against OLS changes with the shape of the profitability distribution. Considering the MAFE and mean squared forecast error (MSFE) criteria together, quantile regression is more accurate relative to OLS when the profitability to be forecast has a heavier-tailed distribution. In addition, the asymmetry of the profitability distribution has either a U-shape or an inverted-U-shape effect on the forecasting accuracy of quantile regression. An application of the distributional shape analysis framework to cash flows forecasting demonstrates the usefulness of the framework beyond profitability forecasting, providing additional empirical evidence on the positive effect of tail-heaviness and supporting the notion of an inverted-U-shape effect of asymmetry

Modeling of the near field plume of a Hall thruster

In this study, a detailed numerical model is developed to simulate the xenon plasma near-field plume from a Hall thruster. The model uses a detailed fluid model to describe the electrons and a particle-based kinetic approach is used to model the heavy xenon ions and atoms. The detailed model is applied to compute the near field plume of a small, 200 W Hall thruster. Results from the detailed model are compared with the standard modeling approach that employs the Boltzmann model. The usefulness of the model detailed is assessed through direct comparisons with a number of different measured data sets. The comparisons illustrate that the detailed model accurately predicts a number of features of the measured data not captured by the simpler Boltzmann approach. © 2004 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70104/2/JAPIAU-95-9-4575-1.pd

Predicting Hall Thruster Operational Lifetime

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76444/1/AIAA-2004-3953-127.pd

The safety and efficacy of mesenchymal stem cells for prevention or regeneration of intervertebral disc degeneration: a systematic review

General Posters: abstract no. GP86INTRODUCTION: Mesenchymal stem cells (MSCs) have been used to halt the progression or regenerate the disc with hopes to prevent or treat discogenic back pain. However, the safety and efficacy of the use of MSCs for such treatment in animal and human models at short and long term assessment (i.e. greater than 48 weeks) have not been systematically addressed. This study addressed a systematic review of comparative controlled studies addressing the use of MSCs to that of no treatment/saline for the treatment of disc degeneration. METHODS: Online databases were extensively searched. Controlled trials in animal models and humans were eligible for inclusion. Trial design, MSC characteristics, injection method, disc assessment, outcome intervals, and complication events were assessed. Validity of each study was assessed addressing trial design. Two individuals independently addressed the aforementioned. RESULTS: Twenty-two animal studies were included. No human comparative controlled trials were reported. All three types of MSCs (i.e. derived from bone marrow, synovial and adipose tissue) showed successful inhibition of disc degeneration progression. From three included studies, bone marrow derived MSC showed superior quality of disc repair when compared to other treatments, including TGF-β1, NP bilaminar co-culture and axial distraction regimen. However, osteophyte development was reported in two studies as potential complication of MSC transplantation. CONCLUSIONS: Based on animal models, the current evidence suggests that in the short-term MSC transplantation is safe and effective in halting disc degeneration; however, additional and larger studies are needed to assess the long-term regenerative effects and potential complications. Inconsistency in methodological design and outcome parameters prevent any robust conclusions. In addition, randomized controlled trials in humans are needed to assess the safety and efficacy of such therapy.published_or_final_versio

Performance of domestic and foreign-invested enterprises in China

Despite increasing attention paid to China's enterprise reform since the late 1970s, relatively little is known about the performance of reformed state-owned enterprises (SOEs) and newly formed private firms vis-à-vis foreign firms in China. In this study, we examine the performance of domestic Chinese firms in various ownership categories versus foreign-invested enterprises (FIEs) based on two nation-wide surveys conducted by the National Bureau of Statistics in 1998 and 2002. We found that both domestic non-state-owned firms and foreign-invested enterprises performed better than state-owned enterprises. Meanwhile, three categories of Chinese firms-privately owned, collectively owned, and shareholding-had higher performance levels than the foreign-invested enterprises. © 2005 Elsevier Inc. All rights reserved.postprin

An Evaluation of Sources of Erosion in Hall Thrusters

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76799/1/AIAA-2005-3530-604.pd

An Investigation of Factors Involved in Hall Thruster Wall Erosion Modeling

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76234/1/AIAA-2006-4657-608.pd