Neutrino oscillations and Lorentz Invariance Violation in a Finslerian Geometrical model

Neutrino oscillations are one of the first evidences of physics beyond the Standard Model (SM). Since Lorentz Invariance is a fundamental symmetry of the SM, recently also neutrino physics has been explored to verify the eventual modification of this symmetry and its potential magnitude. In this work we study the consequences of the introduction of Lorentz Invariance Violation (LIV) in the high energy neutrinos propagation and evaluate the impact of this eventual violation on the oscillation predictions. An effective theory explaining these physical effects is introduced via Modified Dispersion Relations. This approach, originally introduced by Coleman and Glashow, corresponds in our model to a modification of the special relativity geometry. Moreover, the generalization of this perspective leads to the introduction of a maximum attainable velocity which is specific of the particle. This can be formalized in Finsler geometry, a more general theory of space-time. In the present paper the impact of this kind of LIV on neutrino phenomenology is studied, in particular by analyzing the corrections introduced in neutrino oscillation probabilities for different values of neutrino energies and baselines of experimental interest. The possibility of further improving the present constraints on CPT-even LIV coefficients by means of our analysis is also discussed.Comment: Accepted for publication with minor revisions, will appear on European Physics Journal

Neoadjuvant eribulin mesylate following anthracycline and taxane in triple negative breast cancer: Results from the HOPE study

Background Eribulin mesylate (E) is indicated for metastatic breast cancer patients previously treated with anthracycline and taxane. We argued that E could also benefit patients eligible for neoadjuvant chemotherapy. Methods Patients with primary triple negative breast cancer 2 cm received doxorubicin 60 mg/m2 and paclitaxel 200 mg/m2 x 4 cycles (AT) followed by E 1.4 mg/m2 x 4 cycles. Primary endpoint was pathological complete response (pCR) rate; secondary and explorative endpoints included clinical/metabolic response rates and safety, and biomarker analysis, respectively. Using a two-stage Simon design, 43 patients were to be included provided that 4 of 13 patients had achieved pCR in the first stage of the study. Results In stage I of the study 13 women were enrolled, median age 43 years, tumor size 2–5 cm in 9/13 (69%), positive nodal status in 8/13 (61%). Main grade 3 adverse event was neutropenia (related to AT and E in 4 and 2 cases, respectively). AT followed by E induced clinical complete + partial responses in 11/13 patients (85%), pCR in 3/13 (23%). Median measurements of maximum standardized uptake value (SUVmax) resulted 13, 3, and 1.9 at baseline, after AT and E, respectively. Complete metabolic response (CMR) occurred after AT and after E in 2 and 3 cases, respectively. Notably, 2 of the 5 (40%) patients with CMR achieved pCR at surgery. Immunostaining of paired pre-/post-treatment tumor specimens showed a reduction of β-catenin, CyclinD1, Zeb-1, and c-myc expression, in the absence of N-cadherin modulation. The study was interrupted at stage I due to the lack of the required patients with pCR. Conclusions Despite the early study closure, preoperative E following AT showed clinical and biological activity in triple negative breast cancer patients. Furthermore, the modulation of β-catenin pathway core proteins, supposedly outside the domain of epithelial–mesenchymal transition, claims for further investigation. Trial registration EU Clinical Trial Register, EudraCT number 2012-004956-12

M2-Branes and Fano 3-folds

A class of supersymmetric gauge theories arising from M2-branes probing Calabi-Yau 4-folds which are cones over smooth toric Fano 3-folds is investigated. For each model, the toric data of the mesonic moduli space is derived using the forward algorithm. The generators of the mesonic moduli space are determined using Hilbert series. The spectrum of scaling dimensions for chiral operators is computed.Comment: 128 pages, 39 figures, 42 table

Phases of M2-brane Theories

We investigate different toric phases of 2+1 dimensional quiver gauge theories arising from M2-branes probing toric Calabi-Yau 4 folds. A brane tiling for each toric phase is presented. We apply the 'forward algorithm' to obtain the toric data of the mesonic moduli space of vacua and exhibit the equivalence between the vacua of different toric phases of a given singularity. The structures of the Master space, the mesonic moduli space, and the baryonic moduli space are examined in detail. We compute the Hilbert series and use them to verify the toric dualities between different phases. The Hilbert series, R-charges, and generators of the mesonic moduli space are matched between toric phases.Comment: 60 pages, 28 figures, 6 tables. v2: minor correction

A conical deficit in the AdS4/CFT3 correspondence

Inspired by the AdS/CFT correspondence we propose a new duality that allow the study of strongly coupled field theories living in a 2+1 conical space-time. Solving the 4-d Einstein equations in the presence of an infinite static string and negative cosmological constant we obtain a conical AdS4 space-time whose boundary is identified with the 2+1 cone found by Deser, Jackiw and 't Hooft. Using the AdS4/CFT3 correspondence we calculate retarded Green's functions of scalar operators living in the cone.Comment: v3, 14 pages. We reinterpret our results for the Green's functions in the con