406 research outputs found
Accuracy Evaluation of an Optical Lattice Clock with Bosonic Atoms
We report the first accuracy evaluation of an optical lattice clock based on
the 1S0 - 3P0 transition of an alkaline earth boson, namely 88Sr atoms. This
transition has been enabled using a static coupling magnetic field. The clock
frequency is determined to be 429 228 066 418 009(32) Hz. The isotopic shift
between 87Sr and 88Sr is 62 188 135 Hz with fractional uncertainty 5.10^{-7}.
We discuss the conditions necessary to reach a clock accuracy of 10^{-17} or
less using this scheme.Comment: 3 pages, 4 figures, uses ol.sty fil
Ultrastable Optical Clock with Neutral Atoms in an Engineered Light Shift Trap
An ultrastable optical clock based on neutral atoms trapped in an optical
lattice is proposed. Complete control over the light shift is achieved by
employing the transition of
atoms as a "clock transition". Calculations of ac multipole polarizabilities
and dipole hyperpolarizabilities for the clock transition indicate that the
contribution of the higher-order light shifts can be reduced to less than 1
mHz, allowing for a projected accuracy of better than .Comment: 4 pages, 2 figures, accepted for publication in Phys. Rev. Let
Trapping of Neutral Mercury Atoms and Prospects for Optical Lattice Clocks
We report a vapor-cell magneto-optical trapping of Hg isotopes on the
intercombination transition. Six abundant isotopes, including
four bosons and two fermions, were trapped. Hg is the heaviest non-radioactive
atom trapped so far, which enables sensitive atomic searches for ``new
physics'' beyond the standard model. We propose an accurate optical lattice
clock based on Hg and evaluate its systematic accuracy to be better than
. Highly accurate and stable Hg-based clocks will provide a new
avenue for the research of optical lattice clocks and the time variation of the
fine-structure constant.Comment: 4 pages, 3 figure
An Optical Lattice Clock with Spin-polarized 87Sr Atoms
We present a new evaluation of an 87Sr optical lattice clock using spin
polarized atoms. The frequency of the 1S0-3P0 clock transition is found to be
429 228 004 229 873.6 Hz with a fractional accuracy of 2.6 10^{-15}, a value
that is comparable to the frequency difference between the various primary
standards throughout the world. This measurement is in excellent agreement with
a previous one of similar accuracy
Accurate spectroscopy of Sr atoms
We report the frequency measurement with an accuracy in the 100 kHz range of
several optical transitions of atomic Sr : at 689 nm, at 688 nm and at 679 nm. Measurements are performed with
a frequency chain based on a femtosecond laser referenced to primary frequency
standards. They allowed the indirect determination with a 70 kHz uncertainty of
the frequency of the doubly forbidden 5s^2^1S_0- 5s5p^3P_0 transition of
Sr at 698 nm and in a second step its direct observation. Frequency
measurements are performed for Sr and Sr, allowing the
determination of , and isotope shifts, as well as the
hyperfine constants.Comment: 12 pages, 16 figure
Coherence of Spin-Polarized Fermions Interacting with a Clock Laser in a Stark-Shift-Free Optical Lattice
We investigated the coherence of spin-polarized ^{87}Sr atoms trapped in a
light-shift-free one-dimensional optical lattice during their interaction with
a clock laser on the ^1S_0-^3P_0 transition. Collapses and revivals appeared
for more than 50 Rabi cycles, attributed to the thermal distribution of
discrete vibrational states in the lattice potential. The population
oscillation in the clock states lasted more than 1s, demonstrating high
immunity from decoherence. This long atomic coherence suggests the feasibility
of Pauli blocking of collisions in optical clock excitation.Comment: 10 pages, 4 figure
p35, the non-cyclin activator of Cdk5, protects podocytes against apoptosis in vitro and in vivo
Cyclin-dependent kinase-5 is widely expressed and predominantly regulated by the non-cyclin activator p35. Since we recently showed that expression of p35 in the kidney is restricted to podocytes, we examined here its function in mice in which p35 was genetically deleted. The mice did not exhibit kidney abnormalities during glomerular development or during adult life. Conditionally immortalized cultured podocytes, derived from these null mice, did not have any change in their morphology, differentiation, or proliferation. However, when these cultured podocytes were exposed to UV-C irradiation, serum depletion, puromycin aminonucleoside, or transforming growth factor-β-1, they showed increased apoptosis compared to those from wild-type mice. Levels of Bcl-2 were decreased in these null podocytes but increased after transduction with human p35. Restoration of p35 or the ectopic expression of Bcl-2 reduced the susceptibility of p35-null podocytes to apoptosis. Experimental glomerulonephritis, characterized by podocyte apoptosis and subsequent crescent formation, was utilized to test these findings in vivo. Podocyte apoptosis was significantly increased in diseased p35-null compared with wild-type mice, accompanied by increased glomerulosclerosis and decreased renal function. Our study shows that p35 does not affect glomerulogenesis but controls podocyte survival following injury, in part, by regulating Bcl-2 expression
A high stability semiconductor laser system for a Sr-based optical lattice clock
We describe a frequency stabilized diode laser at 698 nm used for high
resolution spectroscopy of the 1S0-3P0 strontium clock transition. For the
laser stabilization we use state-of-the-art symmetrically suspended optical
cavities optimized for very low thermal noise at room temperature. Two-stage
frequency stabilization to high finesse optical cavities results in measured
laser frequency noise about a factor of three above the cavity thermal noise
between 2 Hz and 11 Hz. With this system, we demonstrate high resolution remote
spectroscopy on the 88Sr clock transition by transferring the laser output over
a phase-noise-compensated 200 m-long fiber link between two separated
laboratories. Our dedicated fiber link ensures a transfer of the optical
carrier with frequency stability of 7 \cdot 10^{-18} after 100 s integration
time, which could enable the observation of the strontium clock transition with
an atomic Q of 10^{14}. Furthermore, with an eye towards the development of
transportable optical clocks, we investigate how the complete laser system
(laser+optics+cavity) can be influenced by environmental disturbances in terms
of both short- and long-term frequency stability.Comment: 9 pages, 9 figures, submitted to Appl. Phys.
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