Insights into the time course of evidentiality processing in Turkish heritage speakers using a self-paced reading task

Introduction: Studies with heritage language speakers (HLS) have often used offline measurements, investigating the post-interpretive effects which emerge after processing has been completed. Relatively few studies have investigated heritage language processing using time-sensitive methods that allow the collection of evidence regarding real-time language processing rather than post-interpretive judgments. Using a self-paced-reading paradigm, we aimed to expand our understanding of HLS language processing by investigating evidentiality-the linguistic marking of information source, which is grammatically expressed in Turkish, but not in English. Method: Participants were 54 bilingual speakers of Turkish and English: 24 HLS (English onset: 0-5 yrs) and 30 emigrant Turkish speakers (ES) who grew up in Turkey before emigrating to Australia (English onset = 6-17 yrs). Participants read sentences with evidential-marked verb forms that either matched or mismatched to the information source context. Word-by-word reading times and end-of-sentence acceptability judgment speed and accuracy were measured. Results: The results showed that although the HLS' responses were slower and less accurate than the ES in both reading times and end-of-sentence acceptability judgments, they showed similarities in online processing patterns. Both groups were faster at reading the mismatching sentences compared to the matching sentences; however, this pattern emerged during the time course of reading first for the indirect condition for the ES, and only later for the direct condition and for the HLS for both evidential conditions. Only HLS read faster in the target region with the direct evidential that is shown to be acquired earlier in childhood, than they did for the indirect evidential which is mastered later. In contrast, the end-of-sentence judgment data showed that while the ES group responded faster to matching direct sentences than matching indirect, this effect was missing for the HLS. Nevertheless, there were similar patterns for accuracy across evidential conditions: both groups were more accurate with the direct evidential. Discussion: Overall, the use of the self-paced-reading paradigm allowed insights into HLS' evidentiality processing above and beyond their generally slower and less accurate processing compared to the reference group. This study provides further evidence for differences in the patterns observed using online vs. post interpretive measures in HLS, reinforcing the importance of combining these methodologies for further understanding of HLS competence and performance.</p

Edge Currents in Non-commutative Chern-Simons Theory from a New Matrix Model

This paper discusses the formulation of the non-commutative Chern-Simons (CS) theory where the spatial slice, an infinite strip, is a manifold with boundaries. As standard star products are not correct for such manifolds, the standard non-commutative CS theory is not also appropriate here. Instead we formulate a new finite-dimensional matrix CS model as an approximation to the CS theory on the strip. A work which has points of contact with ours is due to Lizzi, Vitale and Zampini where the authors obtain a description for the fuzzy disc. The gauge fields in our approach are operators supported on a subspace of finite dimension N+\eta of the Hilbert space of eigenstates of a simple harmonic oscillator with N, \eta \in Z^+ and N \neq 0. This oscillator is associated with the underlying Moyal plane. The resultant matrix CS theory has a fuzzy edge. It becomes the required sharp edge when N and \eta goes to infinity in a suitable sense. The non-commutative CS theory on the strip is defined by this limiting procedure. After performing the canonical constraint analysis of the matrix theory, we find that there are edge observables in the theory generating a Lie algebra with properties similar to that of a non-abelian Kac-Moody algebra. Our study shows that there are (\eta+1)^2 abelian charges (observables) given by the matrix elements (\cal A_i)_{N-1 N-1} and (\cal A_i)_{nm} (where n or m \geq N) of the gauge fields, that obey certain standard canonical commutation relations. In addition, the theory contains three unique non-abelian charges, localized near the N^th level. We show that all non-abelian edge observables except these three can be constructed from the abelian charges above. Using the results of this analysis we discuss the large N and \eta limit.Comment: LaTeX, 16 pages and 2 figures. Comments added in sections 4 and 5. A minor error corrected in section 4. Figures replaced for clarity. Typos correcte

Insights into the time course of evidentiality processing in Turkish heritage speakers using a self-paced reading task

IntroductionStudies with heritage language speakers (HLS) have often used offline measurements, investigating the post-interpretive effects which emerge after processing has been completed. Relatively few studies have investigated heritage language processing using time-sensitive methods that allow the collection of evidence regarding real-time language processing rather than post-interpretive judgments. Using a self-paced-reading paradigm, we aimed to expand our understanding of HLS language processing by investigating evidentiality-the linguistic marking of information source, which is grammatically expressed in Turkish, but not in English.MethodParticipants were 54 bilingual speakers of Turkish and English: 24 HLS (English onset: 0-5 yrs) and 30 emigrant Turkish speakers (ES) who grew up in Turkey before emigrating to Australia (English onset = 6-17 yrs). Participants read sentences with evidential-marked verb forms that either matched or mismatched to the information source context. Word-by-word reading times and end-of-sentence acceptability judgment speed and accuracy were measured.ResultsThe results showed that although the HLS' responses were slower and less accurate than the ES in both reading times and end-of-sentence acceptability judgments, they showed similarities in online processing patterns. Both groups were faster at reading the mismatching sentences compared to the matching sentences; however, this pattern emerged during the time course of reading first for the indirect condition for the ES, and only later for the direct condition and for the HLS for both evidential conditions. Only HLS read faster in the target region with the direct evidential that is shown to be acquired earlier in childhood, than they did for the indirect evidential which is mastered later. In contrast, the end-of-sentence judgment data showed that while the ES group responded faster to matching direct sentences than matching indirect, this effect was missing for the HLS. Nevertheless, there were similar patterns for accuracy across evidential conditions: both groups were more accurate with the direct evidential.DiscussionOverall, the use of the self-paced-reading paradigm allowed insights into HLS' evidentiality processing above and beyond their generally slower and less accurate processing compared to the reference group. This study provides further evidence for differences in the patterns observed using online vs. post interpretive measures in HLS, reinforcing the importance of combining these methodologies for further understanding of HLS competence and performance

The Star Product on the Fuzzy Supersphere

The fuzzy supersphere $S_F^{(2,2)}$ is a finite-dimensional matrix approximation to the supersphere $S^{(2,2)}$ incorporating supersymmetry exactly. Here the star-product of functions on $S_F^{(2,2)}$ is obtained by utilizing the OSp(2,1) coherent states. We check its graded commutative limit to $S^{(2,2)}$ and extend it to fuzzy versions of sections of bundles using the methods of [1]. A brief discussion of the geometric structure of our star-product completes our work.Comment: 21 pages, LaTeX, new material added, minor errors correcte

Cumulative incidence and risk factors for cutaneous squamous-cell carcinoma metastases in organ transplant recipients: the SCOPE-ITSCC metastases study, a prospective multi-center study.

Solid organ transplant recipients (SOTRs) are believed to have an increased risk of metastatic cutaneous squamous-cell carcinoma (cSCC), but reliable data are lacking regarding the precise incidence and associated risk factors. In a prospective cohort study, including 19 specialist dermatology outpatient clinics in 15 countries, patient and tumor characteristics were collected using standardized questionnaires when SOTRs presented with a new cSCC. After a minimum of 2 years of follow-up, relevant data for all SOTRs were collected. Cumulative incidence of metastases was calculated by the Aalen-Johansen estimator. Fine and Gray models were used to assess multiple risk factors for metastases. Of 514 SOTRs who presented with 623 primary cSCCs, 37 developed metastases with a 2-year patient-based cumulative incidence of 6.2%. Risk factors for metastases included location in the head and neck area, local recurrence, size >2cm, clinical ulceration, poor differentiation grade, perineural invasion and deep invasion. A high-stage tumor that is also ulcerated showed the highest risk of metastasis, with a 2-year cumulative incidence of 46.2% (31.9% - 68.4%). SOTRs have a high risk of cSCC metastases and well-established clinical and histological risk factors have been confirmed. High-stage, ulcerated cSCCs have the highest risk of metastasis. [Abstract copyright: Copyright © 2024. Published by Elsevier Inc.

Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitro

The production of high levels of reactive oxygen species by neutrophils is associated with the local and systemic destructive phenotype found in the chronic inflammatory disease periodontitis. In the present study, we investigated the ability of sulforaphane (SFN) to restore cellular glutathione levels and reduce the hyperactivity of circulating neutrophils associated with chronic periodontitis. Using differentiated HL60 cells as a neutrophil model, here we show that generation of extracellular O2 . - by the nicotinamide adenine dinucleotide (NADPH) oxidase complex is increased by intracellular glutathione depletion. This may be attributed to the upregulation of thiol regulated acid sphingomyelinase driven lipid raft formation. Intracellular glutathione was also lower in primary neutrophils from periodontitis patients and, consistent with our previous findings, patients neutrophils were hyper-reactive to stimuli. The activity of nuclear factor erythroid-2-related factor 2 (Nrf2), a master regulator of the antioxidant response, is impaired in circulating neutrophils from chronic periodontitis patients. Although patients' neutrophils exhibit a low reduced glutathione (GSH)/oxidised glutathione (GSSG) ratio and a higher total Nrf2 level, the DNA-binding activity of nuclear Nrf2 remained unchanged relative to healthy controls and had reduced expression of glutamate cysteine ligase catalytic (GCLC), and modifier (GCLM) subunit mRNAs, compared to periodontally healthy subjects neutrophils. Pre-treatment with SFN increased expression of GCLC and GCM, improved intracellular GSH/GSSG ratios and reduced agonist-activated extracellular O2 . - production in both dHL60 and primary neutrophils from patients with periodontitis and controls. These findings suggest that a deficiency in Nrf2-dependent pathways may underpin susceptibility to hyper-reactivity in circulating primary neutrophils during chronic periodontitis. © 2013 Dias et al

Differential effects of alprazolam and clonazepam on the immune system and blood vessels of non-stressed and stressed adult male albino rats

Benzodiazepines belongs to one of the most commonly used anxiolytic and anticonvulsant drugs in the world. Full description of toxic effects on different organs is lacking for nearly all the current benzodiazepines. The aim of the current work was to study the immunologic and vascular changes induced by sub-chronic administration of alprazolam and clonazepam in non-stressed and stressed adult male albino rats. Forty-two adult male albino rats were divided into 6 groups (I): (Ia) Negative control rats, (Ib): Positive control rats received distilled water, (II): Stressed rats, (III): Non-stressed rats received daily oral dose of clonazepam (0.5 mg/kg), (IV): Stressed rats received daily oral dose of clonazepam (0.5 mg/kg), (V): Non-stressed rats received daily oral dose of alprazolam (0.3 mg/kg). (VI): Stressed rats received daily oral dose of alprazolam (0.3 mg/kg). At the end of the 4th week, total leukocyte count (WBCs) and differential count were determined, anti-sheep RBC antibody (Anti-SRBC) titer and interleukin-2 (IL-2) level were assessed, thymus glands, lymph nodes, spleens and abdominal aortae were submitted to histopathological examination. Alprazolam was found to induce a significant increase in neutrophil count and a significant decrease in lymphocytes, anti-SRBC titer and IL-2 level with severe depletion of the splenic, thymal and nodal lymphocytes, accompanied by congestion and eosinophilic vasculitis of all organs tested in comparison to clonazepam treated rats. Stress enhanced the toxic effects. It was concluded that the immune system and blood vessels can be adversely affected to a greater extent by short-term chronic administration of alprazolam than by clonazepam, and these toxic effects are aggravated by stress