Livestock, livelihoods and vulnerability in Lesotho, Malawi and Zambia: designing livestock interventions for emergency situations

This study assesses the contributions of livestock to risk management and coping strategies and to identify livestock-centred interventions that can be used to save lives and livelihoods in crisis and emergency situations in selected countries of the Southern Africa Development Community (SADC). The specific objectives are to analyse the roles of livestock in household livelihood strategies; to examine different sources of risks and household risk management and coping strategies, paying particular attention to livestock-based strategies; to identify emergency response interventions including targeted livestock interventions for reducing food insecurity and vulnerability; and to provide a framework for identifying guiding principles for linking livelihood analysis, project and program design, and implementation in emergency situations. The countries covered in this study are Lesotho, Malawi and Zambia. The ratio of vulnerability to food insecurity appears to be growing in all of these countries with vulnerable households facing dwindling food stocks and rising prices of staple food at the time of the study (UN-RIACSO 2005)

Designing livestock interventions for emergency situations in Southern Africa

This brief is a review of the research conducted by the International Livestock Research Institute (ILRI) and partners in Lesotho, Malawi and Zambia aimed to assess the contribution of livestock to livelihoods and its role in risk management. The objective of the study was to identify the livelihood assets and strategies of households, taking into account differences between men and women and the contexts that translate household capabilities into livelihood opportunities. The study suggests that there are marked differences in ownership of productive assets, in livelihood strategies and in vulnerability between men and women. The results of the study showed that households in southern Africa are exposed to a variety of shocks with cumulative impacts that can trigger an emergency. The main factors contributing to vulnerability to food insecurity include drought, widespread crop failure, animal diseases and declining access to livestock service delivery. These factors affect all households in a community but in different ways

Zimbabwe’s land reform: challenging the myths

Most commentary on Zimbabwe’s land reform insists that agricultural production has almost totally collapsed, that food insecurity is rife, that rural economies are in precipitous decline, that political ‘cronies’ have taken over the land and that farm labour has all been displaced. This paper however argues that the story is not simply one of collapse and catastrophe; it is much more nuanced and complex, with successes as well as failures. The paper provides a summary of some of the key findings from a ten-year study in Masvingo province and the book Zimbabwe’s Land Reform: Myths and Realities. The paper documents the nature of the radical transformation of agrarian structure that has occurred both nationally and within the province, and the implications for agricultural production and livelihoods. A discussion of who got the land shows the diversity of new settlers, many of whom have invested substantially in their new farms. An emergent group ‘middle farmers’ is identified who are producing, investing and accumulating. This has important implications – both economically and politically – for the future, as the final section on policy challenges discusses.ESR

Safety and pharmacokinetics of MM-302, a HER2-targeted antibody–liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: A phase 1 dose-escalation study

BackgroundThis phase 1 dose-escalation trial studied MM-302, a novel HER2-targeted PEGylated antibody-liposomal doxorubicin conjugate, in HER2-positive locally advanced/metastatic breast cancer.MethodsPatients were enrolled in four cohorts: MM-302 monotherapy (8, 16, 30, 40, and 50 mg/m2 every 4 weeks [q4w]); MM-302 (30 or 40 mg/m2 q4w) plus trastuzumab (4 mg/kg q2w); MM-302 (30 mg/m2) plus trastuzumab (6 mg/kg) q3w; MM-302 (30 mg/m2) plus trastuzumab (6 mg/kg) and cyclophosphamide (450 mg/m2) q3w.ResultsSixty-nine patients were treated. The most common adverse events (AEs) were fatigue and nausea. Grade 3/4 AEs of special interest included neutropenia, fatigue, mucosal inflammation, anemia, thrombocytopenia, febrile neutropenia, and palmar-plantar erythrodysesthesia. The MTD was not reached. With MM-302 ≥ 30 mg/m2, overall response rate (ORR) was 13% and median progression-free survival (mPFS) 7.4 months (95% CI: 3·5-10·9) in all arms. In 25 anthracycline-naïve patients, ORR was 28·0% and mPFS 10·9 months (95% CI: 1·8-15·3). Imaging with 64Cu-labeled MM-302 visualized tumor-drug penetrance in tumors throughout the body, including the brain.ConclusionMM-302 monotherapy, in combination with trastuzumab, or trastuzumab plus cyclophosphamide, was well tolerated and showed promising efficacy. The selected phase 2 MM-302 dose was 30 mg/m2 plus 6 mg/kg trastuzumab q3w

Evolution of social science research at ICRISAT, and a case study in Zimbabwe

Social science research (SSR) at ICRISAT evolved in the context of its socio-economics program, covering agricultural economics, science and technology policy, rural sociology, and anthropology (Byerlee 2001). These disciplines play complementary roles in obtaining a basic understanding of the rural economy in the semi-arid tropics (SAT), identifying priorities for research, informing policy, monitoring research impacts and helping to direct investments by ICRISAT’s partners. The first part of this paper analyzes the evolution of SSR in ICRISAT. The second part is a recent case study on livelihood diversification behavior among smallholder farm communities in Zimbabwe. It illustrates how SSR contributes to livelihood analysis, targeting of research and development, and informing policy. The structure and content of SSR at ICRISAT has been shaped by the Institute’s overall research strategies over time. Before 1996, ICRISAT’s major emphasis was on increasing production and food security through new technologies and new uses for our mandate crops. The strategy focused on more efficient use of small quantities of inputs and their timely application to enrich nutrient-poor soils. In the latter half of the 1990s, there was renewed effort on problem-based, impact-driven science and delivery of outputs. By 1997, the Institute’s strategy aimed to identify alternative uses of the natural resource base that could help reduce poverty, promote food security, and prevent environmental degradation. In line with these changes, socio-economics research focused on analysis of the potential of agriculture in the semiarid tropics, alternative investment strategies, input and output markets, and policy. In accordance with the CGIAR’s vision of a food-secure world by 2010, ICRISAT’s vision today is to improve the wellbeing of the SAT poor through agricultural research for impact. The Institute has a mandate to enhance the livelihoods of the poor in semi-arid farming systems through integrated management of genetic and natural resources (ICRISAT 1980–2003)

Detection of bovine-virus-diarrhoea-virus antibodies in cattle with an enzyme-linked immunosorbent assay

The serum-neutralization (SN) and the indirect-immunofluorescence (IIF) assays have invariably been used for detecting antibodies against bovine virus diarrhoea virus (BVDV) in cattle sera. An enzyme-linked immunosorbent assay (ELISA) was applied which has a sensitivity comparable with the SN and IIF in detecting antibody to BVDV. A total of 472 bovine sera were assayed and a high prevalence of 79,2% was recorded. Positive correlations between the ELISA and the SN were found when certain sera were assayed, implying that the former test could then be used for routine diagnosis of BVDV.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.University of Zimbabwe Research Board. European Union.mn201

Evolution of Social Science Research at ICRISAT, and a Case Study in Zimbabwe. Working Paper Series no. 20

This paper consists of two distinct yet complementary parts. The first part analyzes the evolution of social science research (SSR) at ICRISAT. It describes the initiation of SSR, its continued recognition and incorporation in the Institute's research strategy, its structure, staff strength, collaboration and partnerships; and the constraints faced by SSR - including debates on relevance and performance, and how these have been dealt with within the Institute. The second part was motivated by the CGIAR's thrust to enhance the contribution of SSR to sustainable agricultural development, food security, and poverty eradication. It is a case study of livelihood diversification behavior among smallholder farm communities in Zimbabwe and illustrates how SSR contributes to livelihood analysis, targeting of research and development, and informing policy. It addresses several key questions: Given the changing environment in the semi-arid tropics, what factors constrain rural livelihoods? How do resource-poor smallholder farm households cope with these constraints? How do their coping strategies impact on farmer investment behavior? And what are the implications for targeting of research and development

Diabetes Mellitus in HIV-Infected Patients Receiving Antiretroviral Therapy

Background. There is little in the literature on HIV and diabetes mellitus (DM) in sub-Saharan Africa. Objective. To assess the characteristics of HIV and DM in patients receiving antiretroviral therapy (ART) in Botswana. Methods. A retrospective case-control study was conducted at 4 sites. Each HIV-infected patient with DM (n=48) was matched with 2 HIV-infected controls (n=108) by age (±2 years) and sex. Primary analysis was conditional logistic regression to estimate univariate odds and 95% confidence intervals (CIs) for each characteristic. Results. There was no significant association between co-morbid diseases, tuberculosis, hypertension or cancer and risk of diabetes. DM patients were more likely to have higher pre-ART weight (odds ratio (OR) 1.09; 95% CI 1.04 - 1.14). HIV-infected adults \u3e70 kg were significantly more likely to have DM (OR 12.30; 95% CI 1.40 - 107.98). Participants receiving efavirenz (OR 4.58; 95% CI 1.44 - 14.57) or protease inhibitor therapy (OR 20.7; 95% CI 1.79 - 240.02) were more likely to have DM. Neither mean pre-ART CD4 cell count (OR 1.0; 95% CI 0.99 - 1.01) nor pre-ART viral load \u3e100 000 copies/ml (OR 0.71; 95% CI 0.21 - 2.43) were associated with a significant risk of diabetes. Conclusions. These findings suggest a complex interrelation among traditional host factors and treatment-related metabolic changes in the pathogenesis of DM inpatients receiving ART. Notably, pre-ART weight, particularly if \u3e70 kg, is associated with the diagnosis of diabetes in HIV-infected patients in Botswana

Impact and sustainability of low-head drip irrigation kits, in the semi-arid Gwanda and Beitbridge Districts, Mzingwane Catchment, Limpopo Basin, Zimbabwe

Resource-poor smallholder farmers in the semi-arid Gwanda and Beitbridge districts face food insecurity on an annual basis due to a combination of poor and erratic rainfall (average 500 mm/a and 345 mm/a, respectively, for the period 1970–2003) and technologies inappropriate to their resource status. This impacts on both household livelihoods and food security. In an attempt to improve food security in the catchment a number of drip kit distribution programmes have been initiated since 2003 as part of an on-going global initiative aimed at 2 million poor households per year. A number of recent studies have assessed the technical performance of the drip kits in-lab and in-field. In early 2005 a study was undertaken to assess the impacts and sustainability of the drip kit programme. Representatives of the NGOs, local government, traditional leadership and agricultural extension officers were interviewed. Focus group discussions with beneficiaries and other villagers were held at village level. A survey of 114 households was then conducted in two districts, using a questionnaire developed from the output of the interviews and focus group discussions..