Prime Submodules And A Sheaf On The Prime Spectra Of Modules

We define and investigate a sheaf of modules on the prime spectra of modules and it is shown that there is an isomorphism between the sections of this sheaf and the ideal transform module

Localized modes in defective multilayer structures

In this paper, the localized surface modes in a defective multilayer structure has been investigated. It is shown that the defective multilayer structures can support two different kind of localized modes depending on the position and the thickness of the defect layer. One of these modes is localized at the interface between the multilayer structure and a homogeneous medium (the so-called surface mode) and the other one is localized at the defect layer (defect localized mode). We reveal that the presence of defect layer pushes the dispersion curve of surface modes to the lower or the upper edge of the photonic bandgap depending on the homogeneous medium is a left-handed or right-handed medium (e.g. vacuum), respectively. So, the existence region of the surface modes restricted. Moreover, the effect of defect on the energy flow velocity of the surface modes is discussed.Comment: 5 pages, 7 figure

PLAST-ncRNA: Partition function Local Alignment Search Tool for non-coding RNA sequences

Alignment-based programs are valuable tools for finding potential homologs in genome sequences. Previously, it has been shown that partition function posterior probabilities attuned to local alignment achieve a high accuracy in identifying distantly similar non-coding RNA sequences that are hidden in a large genome. Here, we present an online implementation of that alignment algorithm based on such probabilities. Our server takes as input a query RNA sequence and a large genome sequence, and outputs a list of hits that are above a mean posterior probability threshold. The output is presented in a format suited to local alignment. It can also be viewed within the PLAST alignment viewer applet that provides a list of all hits found and highlights regions of high posterior probability within each local alignment. The server is freely available at http://plastrna.njit.edu

Preparation, Characterisation and Photocatalytic Applications of TiO2-MWCNTs Composite

The nanocomposite of TiO2-MWCNTs has been synthesised by simple hydrothermal route showing significant enhancement in the photocatalytic activity for the degradation of methyl orange dye (MO). Several characterisations employed were X-ray diffraction (XRD), Scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), Transmission electron microscopy (TEM), Raman spectroscopy.XRD pattern shows the formation of anatase phase in prepared TiO2 which was retained in TiO2-MWCNTs composite as well. The Raman spectrum of prepared TiO2-MWCNT shows the interface integration of TiO2 and MWCNTs which is further supported by TEM data. Complete decolorisation and degradation of dye using TiO2-MWCNTs nanocomposite has been observed only in 45 minutes of UV irradiation. 65 per cent reduction in chemical oxygen demand (COD) value of treated dye shows substantial mineralisation of dye by composite catalyst. Dye degradation reactions were found to follow first order kinetics.Defence Science Journal, 2013, 63(4), pp.435-441, DOI:http://dx.doi.org/10.14429/dsj.63.487

Preformed metal crowns may last longer than fillings

Copyright: Copyright 2007 Elsevier B.V., All rights reserved.Data sources: Searches were made using the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase and the System for Information on Grey Literature in Europe (SIGLE). Study selection: Randomised controlled trials (RCT) were chosen that assessed the effectiveness of PMC, compared with filling materials or in children where there had been no treatment of tooth decay in one or more primary molar teeth. Data extraction and synthesis: Forty-seven records were retrieved by the search strategies, some of which proved to be duplicates. Ultimately, 14 studies were scrutinised. None met the inclusion criteria and six studies were excluded from the review because they were either retrospective in design or they reported prospective outcomes but were not randomised. Conclusions: No RCT were available for appraisal. Although the use of PMC is recommended in clinical practice by the British Society of Paediatric Dentistry (BSPD), the evidence to support this is not strong, consisting mainly of case reports and uncontrolled studies. The lower quality levels of evidence that have been produced nevertheless have some strength, since clinical outcomes are consistently in favour of PMC even though many studies analyse casts placed on the most damaged of the pair of teeth. It is important that the absence of evidence for PMC is not misinterpreted as evidence for their lack of efficacy.publishersversionPeer reviewe

Phase II study of TP300 in patients with advanced gastric or gastro-oesophageal junction adenocarcinoma

Background: TP300, a recently developed synthetic camptothecin analogue, is a highly selective topoisomerase I inhibitor. A phase I study showed good safety and tolerability. As camptothecins have proven active in oesophago-gastric adenocarcinomas, in this phase II study we assessed the efficacy and safety of TP300 in patients with gastric or gastro-oesophageal junction (GOJ) adenocarcinomas. Methods: Eligible patients had metastatic or locally advanced gastric or Siewert Types II or III GOJ inoperable adenocarcinoma. Patients were chemotherapy naïve unless this had been administered in the perioperative setting. TP300 was administered as a 1-h intravenous infusion every 3 weeks (a cycle) for up to 6 cycles at a starting dose of 8 mg/m2 with intra-patient escalation to 10 mg/m2 from cycle 2 in the absence of dose-limiting toxicity. Tumour responses (RECIST 1.1) were assessed every 6 weeks. Toxicity was recorded by NCI-CTCAE version 3.0. Using a modified two-stage Simon design (Stage I and II), a total of 43 patients were to be included providing there were 3 of 18 patients with objective response in Stage I of the study. Results: In Stage I of the study 20 patients (14 males, 6 females), median age 67 years (range 40 − 82), performance status ECOG 0/1, with GC [14] or GOJ carcinoma [6] were enrolled. Of the 16 evaluable patients, 11 received the planned dose increase to 10 mg/m2 at cycle 2, 2 decreased to 6 mg/m2, and 3 continued on 8 mg/m2. There were no objective responses after 2 cycles of treatment. Twelve patients had stable disease for 1 − 5 months and 4 had progressive disease. Median progression free survival (PFS) was 4.1 months (CI [1.6 − 4.9]), median time to progression (TTP) was 2.9 months (CI [1.4 − 4.2]). Grade 3/4 toxicities (worst grade all cycles) included 7 patients (35 %) with neutropenia, 4 patients (20 %) with anaemia, 2 patients (10 %) with thrombocytopenia, and 3 patients (15 %) with fatigue. This study was terminated at the end of Stage I due to a lack of the required (3/18) responders. Conclusions: This study of TP300 showed good drug tolerability but it failed to demonstrate sufficient efficacy as measured by radiological response

Functional evaluation of various modalities of management in floating knee injuries at a tertiary care centre in central India

Background: The injuries involving femur and tibia fractures due to high velocity are known as floating knee injuries. These fractures may involve the shaft, metaphysis or the articular surface. There are many complications associated with these injuries. This study evaluates the functional, clinical and radiological outcomes of floating knee injuries. Methods: A Prospective and interventional study was performed at MGMMC and MYH Hospital, Indore. We included 30 patients in our study. Femur fractures are managed by intramedullary nailing or distal femur plating. Tibia fractures are managed by Intramedullary nailing or tibia plating. Patient were called for regular follow up for a minimum of 6 months. Functional and clinical evaluation done by Karlstorm and olerud scoring system and radiological outcome by union on x rays were done. Results: Out of 30 patients 28 (93.33%) male and 2 (6.66%) female. According to Fraser classification, 17 (56.66%) type 1, 4 (13.33%) type 2A, 4 (13.33%) type2B, 5 (16.66%) type 2C injuries. A majority of the injuries occurred due to road traffic accidents involving right limb 21 (70%) more then left 9 (30%). Knee stiffness occurred in 8, infection in femur 3, infection in tibia 2, malunion of femur 2, limb length discrepancy in 2 patients. Outcome was excellent in 5 (16.66%), Good in 10 (33.33%), Acceptable in 9 (30%) and poor in 6 (20%). Conclusions: Fraser type 1 fracture has excellent results and Fraser type 2C has poor results. Closed fracture has better outcome compared to compound Fractures. A better functional outcome can be determined on the basis of implant choice based on Fraser Classification, level of injury, open or closed injury, simple or compound type of fracture

On setup level tool sequence selection for 2.5-D pocket machining

Abstract This paper describes algorithms for efficiently machining an entire setup. Previously, the author developed a graph based algorithm to find the optimal tool sequence for machining a single 2.5-axis pocket. This paper extends this algorithm for finding an efficient tool sequence to machine an entire setup. A setup consists of a set of features with precedence constraints, that are machined when the stock is clamped in a particular orientation. The precedence constraints between the features primarily result from nesting of some features within others. Four extensions to the basic graph algorithm are investigated in this research. The first method finds optimal tool sequences on a feature by feature basis. This is a local optimization method that does not consider inter feature toolpath interactions. The second method uses a composite graph for finding an efficient tool sequence for the entire setup. The constrained graph and subgraph approaches have been developed for situations where different features in the setup have distinct critical tools. It is found that the first two methods can produce erroneous results which can lead to machine crashes and incomplete machining. Illustrative examples have been generated for each method.

Longitudinal photocurrent spectroscopy of a single GaAs/AlGaAs v-groove quantum wire

Modulation-doped GaAs v-groove quantum wires (QWRs) have been fabricated with novel electrical contacts made to two-dimensional electron-gas (2DEG) reservoirs. Here, we present longitudinal photocurrent (photoconductivity/PC) spectroscopy measurements of a single QWR. We clearly observe conductance in the ground-state one-dimensional subbands; in addition, a highly temperature-dependent response is seen from other structures within the v-groove. The latter phenomenon is attributed to the effects of structural topography and localization on carrier relaxation. The results of power-dependent PC measurements suggest that the QWR behaves as a series of weakly interacting localized states, at low temperatures