18 research outputs found
Both cytochromes P450 1A and 3A4 are involved in the N-demethylation of tamoxifen
info:eu-repo/semantics/publishe
Toxicity and metabolism of tamoxifen in primary rat hepatocyte cultures
info:eu-repo/semantics/nonPublishe
Effect of retinol and retinoic acid supplemented diets on cytochrome P‐450 content and UDP glucuronosyltransferase activities in vitamin A‐deficient rat liver
Expression of coagulation factor V gene by normal adult human hepatocytes in primary culture
Modeling of Hepatocytes Proliferation Isolated from Proximal and Distal Zones from Human Hepatocellular Carcinoma Lesion
Thyroid cell survival in coculture with autologous peripheral or intrathyroidal lymphocytes
Schistosomal portal hypertension: influence of the portal blood flow in serum levels of hepatic enzymes
Objetivo – Avaliar a relação entre o fluxo sangüíneo portal e o perfil laboratorial hepático em pacientes com hipertensão portal
esquistossomótica. Pacientes e Métodos – Estudaram-se 64 pacientes com hipertensão portal esquistossomótica, sendo 19 não-operados,
23 submetidos a desconexão ázigo-portal com esplenectomia e 22 submetidos a derivação esplenorrenal distal. Avaliou-se o perfil
laboratorial hepático através da dosagem sérica de albumina, transaminases glutâmico-oxalacética e glutâmico-pirúvica, bilirrubinas
direta e indireta, fosfatase alcalina, gama-glutamil transferase e avaliação do tempo de protrombina. O fluxo portal foi avaliado por
Doppler. Os resultados foram analisados através de regressão linear, coeficiente de correlação de Pearson, teste do Qui-quadrado e
análise de variância de um via com pós-teste de Tukey. Resultados – Evidenciou-se que somente a gama-glutamil transferase teve
correlação significativa com o fluxo portal. No cotejo dos quartis, também, somente a gama-glutamil transferase mostrou resultado
significativo, em que se constatou que o quarto quartil, de maior fluxo portal e formado em sua maioria por pacientes não operados,
também foi o de maior valor médio de gama-glutamil transferase e significativamente maior que o primeiro e terceiro quartis. Conclusões –
Estes dados sugerem que: quanto maior o fluxo sangüíneo portal, maior o nível sérico de gama-glutamil transferase; a gama-glutamil
transferase é a variável da avaliação do perfil hepático mais representativa da influência do fluxo portal na atividade funcional hepática
nos pacientes com esquistossomose hepatoesplênica, e é possível que as cirurgias, através de suas modificações hemodinâmicas
(diminuição da congestão), sejam também benéficas por diminuírem o grau de colestase presente ou em regredirem a indução microssomal.
_________________________________________________________________________________________ ABSTRACT: Aim – To evaluate relation between the portal blood flow and the laboratory hepatic screening in patients with schistosomal portal hypertension.
Patients and Methods – Sixty-four patients with schistosomal portal hypertension had studied, being 19 not operated, 23 submitted to esophagogastric
devascularization with splenectomy and 22 submitted to distal splenorenal shunt. Evaluated the laboratory hepatic screening through the dosage of
albumin, aspartate aminotransferase, alanine aminotransferase, direct bilirubin and indirect bilirubin, alkaline phosphatase, gamma-glutamil transferase
and prothrombin time. The portal flow was evaluated for Doppler. The results have been analyzed through linear regression, Pearson correlation coefficient,
chi-square and one-way analysis of variance with Tukey's test. Results – It was proven that only gamma-glutamil transferase had significant correlation
with the portal flow. In compare of the quartiles, also only gamma-glutamil transferase showed resulted significant, it was evidenced that the fourth
quartile, that is bigger portal flow and formed in its majority for patients not operated, also was bigger average of gamma-glutamil transferase and
significantly bigger value than first and the third quartiles. Conclusions – 1. The portal blood flow was bigger in patients that the serum level of GGT was
bigger; 2. the gamma-glutamil transferase is the variable of the hepatic screening evaluation more representative of the portal flow influence in hepatic
functional activity in patients with hepatosplenic schistosomiasis, and 3. probably, the different surgeries through hemodynamics modifications, are
beneficial in to diminish the degree of cholestasis or in decrease the microssomal induction