Experiments on Passive Hypervelocity Boundary-Layer Control Using an Ultrasonically Absorptive Surface

Recently performed linear stability analyses suggested that transition could be delayed in hypersonic boundary layers by using an ultrasonically absorptive surface to damp the second mode (Mack mode). Boundary-layer transition experiments were performed on a sharp 5.06-deg half-angle round cone at zero angle of attack in the T5 Hypervelocity Shock Tunnel to test this concept. The cone was constructed with a smooth surface around half the cone circumference (to serve as a control) and an acoustically absorptive porous surface on the other half. Test gases investigated included nitrogen and carbon dioxide at M∞ ≃ 5 with specific reservoir enthalpy ranging from 1.3 to 13.0 MJ/kg and reservoir pressure ranging from 9.0 to 50.0 MPa. Comparisons were performed to ensure that previous results obtained in similar experiments (on a regular smooth surface) were reproduced, and the results were extended to examine the effects of the porous surface. These experiments indicated that the porous surface was highly effective in delaying transition provided that the pore size was significantly smaller than the viscous length scale

Surgical management of posterior fossa metastases

The diagnosis of brain metastases is associated with a poor prognosis reflecting uncontrolled primary disease that has spread to the relative sanctuary of the central nervous system. 20 % of brain metastases occur in the posterior fossa and are associated with significant morbidity. The risk of acute hydrocephalus and potential for sudden death means these metastases are often dealt with as emergency cases. This approach means a full pre-operative assessment and staging of underlying disease may be neglected and a proportion of patients undergo comparatively high risk surgery with little or no survival benefit. This study aimed to assess outcomes in patients to identify factors that may assist in case selection. We report a retrospective case series of 92 consecutive patients operated for posterior fossa metastases between 2007 and 2012. Routine demographic data was collected plus data on performance status, primary cancer site, details of surgery, adjuvant treatment and survival. The only independent positive prognostic factors identified on multivariate analysis were good performance status (if Karnofsky performance score >70, hazard ratio (HR) for death 0.36, 95 % confidence interval (CI) 0.18–0.69), adjuvant whole brain radiotherapy (HR 0.37, 95 % CI 0.21–0.65) and adjuvant chemotherapy where there was extracranial disease and non-synchronous presentation (HR 0.51, 95 % CI 0.31–0.82). Patients presenting with posterior fossa metastases may not be investigated as thoroughly as those with supratentorial tumours. Staging and assessment is essential however, and in the meantime emergencies related to tumour mass effect should be managed with steroids and cerebrospinal fluid diversion as required

Dizajniranje, sinteza, kinetika hidrolize i farmakodinamski profili konjugata aceklofenaka s histidinom i alaninom

The gastrointestinal toxicity associated with aceclofenac can be reduced by condensing its carboxylic acid group with methyl esters of amino acids like histidine and alanine to give amide linkage by the Schotten-Baumann method. Physicochemical characterization of the conjugates was carried out by various analytical and spectral methods. The synthesized conjugates were also subjected to in vitro hydrolysis in simulated gastric fluid (SGF) at pH 1.2, simulated intestinal fluid (SIF) at pH 7.4 and SIF + 80 % human plasma at pH 7.4. The release of free aceclofenac from histidine and alanine conjugated aceclofenac showed negligible hydrolysis in SGF compared to SIF. This indicated that the conjugates do not break in stomach, but release aceclofenac in SIF. Both synthesized conjugates showed excellent pharmacological response and encouraging hydrolysis rate in SIF and SIF + 80 % human plasma. Marked reduction of the ulcer index and comparable increase in analgesic and anti-inflammatory activities were obtained in both cases compared to aceclofenac alone. These findings suggest that the conjugates are better in action compared to the parent drug and have fewer gastrointestinal side-effects.Gastrointestinalna toksičnost aceklofenaka može se umanjiti kondenzacijom karboksilne skupine aceklofenaka s metilnim esterima aminokiselina poput histidina i alanina, pri čemu se stvaraju nove amidne veze po Schotten-Baumannovoj metodi. Fizikokemijska karakterizacija konjugata provedena je različitim analitičkim i spektralnim metodama. Nadalje, praćena je hidroliza sintetiziranih konjugata in vitro u simuliranoj gastričnoj tekućini (SGF) pri pH 1,2, simuliranoj intestinalnoj tekućini (SIF) pri pH 7,4 i simuliranoj intestinalnoj tekućini s 80 % humane plazme pri pH 7,4. Oslobađanje aceklofenaka iz konjugata s histidinom, odnosno alaninom, bilo je zanemarivo u SGF-u, u odnosu na oslobađanje u SIF-u. To ukazuje da su konjugati stabilni u želucu, dok se u SIF-u iz njih oslobađa aceklofenak. Oba konjugata daju izvrstan farmakološki odgovor i zadovoljavajući stupanj hidrolize u SIF-u i smjesi SIF-a i humane plazme. Oba konjugata pokazala su značajno smanjenu ulcerogenost i pojačano analgetsko i protuupalno djelovanje u odnosu na aceklofenak. Rezultati ukazuju na prednost konjugata u odnosu na samu ljekovitu tvar

Non-asymptotically flat, non-AdS dilaton black holes

We show that previously known non-asymptotically flat static black hole solutions of Einstein-Maxwell-dilaton theory may be obtained as near-horizon limits of asymptotically flat black holes. Specializing to the case of the dilaton coupling constant $\alpha^2 = 3$, we generate from the non-asymptotically flat magnetostatic or electrostatic black holes two classes of rotating dyonic black hole solutions. The rotating dyonic black holes of the ``magnetic'' class are dimensional reductions of the five-dimensional Myers-Perry black holes relative to one of the azimuthal angles, while those of the ``electric'' class are twisted dimensional reductions of rotating dyonic Rasheed black strings. We compute the quasi-local mass and angular momentum of our rotating dyonic black holes, and show that they satisfy the first law of black hole thermodynamics, as well as a generalized Smarr formula. We also discuss the construction of non-asymptotically flat multi-extreme black hole configurations.Comment: Minor corrections. 2 references added. To appear in Physical Review

Rotating 5D-Kaluza-Klein Space-Times from Invariant Transformations

Using invariant transformations of the five-dimensional Kaluza-Klein (KK) field equations, we find a series of formulae to derive axial symmetric stationary exact solutions of the KK theory starting from static ones. The procedure presented in this work allows to derive new exact solutions up to very simple integrations. Among other results, we find exact rotating solutions containing magnetic monopoles, dipoles, quadripoles, etc., coupled to scalar and to gravitational multipole fields.Comment: 24 pages, latex, no figures. To appear in Gen. Rel. Grav., 32, (2000), in pres

How to combine visual features with tags to improve movie recommendation accuracy?

Previous works have shown the effectiveness of using stylistic visual features, indicative of the movie style, in content-based movie recommendation. However, they have mainly focused on a particular recommendation scenario, i.e., when a new movie is added to the catalogue and no information is available for that movie (New Item scenario). However, the stylistic visual features can be also used when other sources of information is available (Existing Item scenario). In this work, we address the second scenario and propose a hybrid technique that exploits not only the typical content available for the movies (e.g., tags), but also the stylistic visual content extracted form the movie files and fuse them by applying a fusion method called Canonical Correlation Analysis (CCA). Our experiments on a large catalogue of 13K movies have shown very promising results which indicates a considerable improvement of the recommendation quality by using a proper fusion of the stylistic visual features with other type of features

All Vacuum Near-Horizon Geometries in DD-dimensions with (D−3)(D-3) Commuting Rotational Symmetries

We explicitly construct all stationary, non-static, extremal near horizon geometries in $D$ dimensions that satisfy the vacuum Einstein equations, and that have $D-3$ commuting rotational symmetries. Our work generalizes [arXiv:0806.2051] by Kunduri and Lucietti, where such a classification had been given in $D=4,5$. But our method is different from theirs and relies on a matrix formulation of the Einstein equations. Unlike their method, this matrix formulation works for any dimension. The metrics that we find come in three families, with horizon topology $S^2 \times T^{D-4}$, or $S^3 \times T^{D-5}$, or quotients thereof. Our metrics depend on two discrete parameters specifying the topology type, as well as $(D-2)(D-3)/2$ continuous parameters. Not all of our metrics in $D \ge 6$ seem to arise as the near horizon limits of known black hole solutions.Comment: 22 pages, Latex, no figures, title changed, references added, discussion of the parameters specifying solutions corrected, amended to match published versio