Testing whether muon neutrino flavor mixing is maximal

The small difference between the survival probabilities of muon neutrino and antineutrino beams, traveling through earth matter in a long baseline experiment such as MINOS, is shown to be an important measure of any possible deviation from maximality in the flavor mixing of those states.Comment: Some revision has been made in the experimental discussions with two new figures replacing the old ones and a clarification of the accuracy of the perturbative result has been included. This version will be published in Physical Review Letters. Title changed as asked by the editors of Physical Review Letter

Prevalence and determinants of hypertension among older adults : a comparative analysis of the 6th and 8th national health surveys of Bangladesh

Background: Hypertension is a major public health concern in low-and middle-income countries. A nationwide Health, Population, and Nutrition Sector Development Program in Bangladesh has been shown to be effective in resource-poor settings. This article aims to investigate whether the prevalence and determinants of adult hypertension changed from 2011 to 2018. Methods: The determinants of adult hypertension were assessed in 2011 and 2018 data of Bangladesh Demographic and Health surveys. These two surveys included both men and women over the age of 34 years and measured their blood pressure, weight, height, and other covariates. For both surveys, we estimated the age-standard prevalence of hypertension and relative, attributable and mediated risk of determinants of hypertension using hierarchical mixed-effects sequential Poisson regression models. Results: The prevalence of adult hypertension increased by 10.9% from 29.5% in 2011 to 40.4% in 2018. The nationwide awareness program on the Health, Population and Nutrition Sector changed the risks associated with hypertension determinants over the years. During 2011, Socio-economic status (SES) was a major distal determinant of adult hypertension, explaining 21% of population-attributable risk (ART). However, other factors accounted for 90% of risk, mainly by excessive body weight (51%) and awareness of hypertension (39%). In contrast, SES only explained 16% of ART risk, with 97% of the risk mediated by excessive body weight (55%) and awareness of hypertension (41%). Conclusion: The study results highlight that hypertension among older adult was significantly increased over the six-year period. Specially, the socio-economic status, awareness of hypertension and excessive body weight were the significant determinants. Being awareness of hypertension and excessive body weight changed the causal pathways of socio-economic status. The results also highlight the value of studying the effect of non-communicable disease awareness programs to enhance our comprehension of factors influencing health

Neutrino masses, cosmological bound and four zero Yukawa textures

Four zero neutrino Yukawa textures in a specified weak basis, combined with $\mu\tau$ symmetry and type-I seesaw, yield a highly constrained and predictive scheme. Two alternately viable $3\times3$ light neutrino Majorana mass matrices $m_{\nu A}/m_{\nu B}$ result with inverted/normal mass ordering. Neutrino masses, Majorana in character and predicted within definite ranges with laboratory and cosmological inputs, will have their sum probed cosmologically. The rate for $0\nu\beta\beta$ decay, though generally below the reach of planned experiments, could approach it in some parameter region. Departure from $\mu\tau$ symmetry due to RG evolution from a high scale and consequent CP violation, with a Jarlskog invariant whose magnitude could almost reach $6\times 10^{-3}$, are explored.Comment: Published versio

Constraints on Baryon-Nonconserving Yukawa Couplings in a Supersymmetric Theory

The 1-loop evolution of couplings in the minimal supersymmetric standard model, extended to include baryon nonconserving $(B\!\!\!/)$ operators through explicit $R$-parity violation, is considered keeping only $B\!\!\!/$ superpotential terms involving the maximum possible number of third generation superfields. If all retained Yukawa couplings $Y_i$ are required to remain in the perturbative domain $(Y_i < 1)$ upto the scale of gauge group unification, upper bounds ensue on the magnitudes of the $B\!\!\!/$ coupling strengths at the supersymmetry breaking scale, independent of the model of unification. They turn out to be similar to the corresponding fixed point values reached from a wide range of $Y_i$ (including all $Y_i$ greater than unity) at the unification scale. The coupled evolution of the top and $B\!\!\!/$ Yukawa couplings results in a reduction of the fixed point value of the former.Comment: PRL-TH-94/8 and TIFR/TH/94-7, 15 pages, LaTe

Constraints On Radiative Neutrino Mass Models From Oscillation Data

The three neutrino Zee model and its extension including three active and one sterile species are studied in the light of new neutrino oscillation data. We obtain analytical relations for the mixing angle in solar oscillations in terms of neutrino mass squared differences. For the four neutrino case, we obtain the result $\mathsf{sin^2 2 \theta_\odot \approx 1 - [ (\Delta m^2_{Atm})^2/(4 \Delta m^2_{LSND} \Delta m^2_\odot) ]^2}$, which can accommodate both the large and small mixing scenarios. We show that within this framework, while both the SMA-MSW and the LMA-MSW solutions can easily be accommodated, it would be difficult to reconcile the LOW-QVO solutions. We also comment on the active-sterile admixture within phenomenologically viable textures.Comment: The paper has been substantially rewritten, especially in Section IV, though the basic results are unchanged. Some new references and an appendix have been adde

New interactions in neutrino oscillations with three light flavors

If one assumes solar and LSND neutrino oscillations to explain the corresponding data, then the atmospheric neutrino deficit cannot be accommodated within the Standard Model with three light flavors, unless one ignores the data's zenith-angle dependence. We propose a novel solution to this problem by postulating large anomalous diagonal $\nu_\tau$-quark interactions which affect $\nu_\mu - \nu_\tau$ oscillations traversing the Earth and induce the observed zenith-angle dependence.Comment: Final version, to appear in Phys. Rev. Letters dated May 25, 199

'Mu-Tau' symmetry, tribimaximal mixing and four zero neutrino Yukawa textures

Within the type-I seesaw framework with three heavy right chiral neutrinos and in the basis where the latter and the charged leptons are mass diagonal, a near `mu-tau' symmetry in the neutrino sector is strongly suggested by the neutrino oscillation data. There is further evidence for a close to the tribimaximal mixing pattern which subsumes `mu-tau' symmetry. On the other hand, the assumption of a (maximally allowed) four zero texture in the Yukawa coupling matrix Y_nu in the same basis leads to a highly constrained and predictive theoretical scheme. We show that the requirement of an exact `mu-tau' symmetry, coupled with observational constraints, reduces the `seventy two' allowed textures in such a `Y_nu' to 'only four' corresponding to just two different forms of the light neutrino mass matrix `m_nu'. The effect of each of these on measurable quantities can be described, apart from an overall factor of the neutrino mass scale, in terms of two real parameters and a phase angle all of which are within very constrained ranges. The additional input of a tribimaximal mixing reduces these three parameters to `only one' with a very nearly fixed value. Implications for both flavored and unflavored leptogenesis as well as radiative lepton flavor violating decays are discussed. We also investigate the stability of these conclusions under small deviations due to renormalization group running from a high scale where the four zero texture as well as `mu-tau' symmetry or the tribimaximal mixing pattern are imposed.Comment: Typographical changes,accepted for publication in JHE

Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers.

We have profiled, for the first time, an evolving human metastatic microenvironment by measuring gene expression, matrisome proteomics, cytokine and chemokine levels, cellularity, extracellular matrix organization, and biomechanical properties, all on the same sample. Using biopsies of high-grade serous ovarian cancer metastases that ranged from minimal to extensive disease, we show how nonmalignant cell densities and cytokine networks evolve with disease progression. Multivariate integration of the different components allowed us to define, for the first time, gene and protein profiles that predict extent of disease and tissue stiffness, while also revealing the complexity and dynamic nature of matrisome remodeling during development of metastases. Although we studied a single metastatic site from one human malignancy, a pattern of expression of 22 matrisome genes distinguished patients with a shorter overall survival in ovarian and 12 other primary solid cancers, suggesting that there may be a common matrix response to human cancer.Significance: Conducting multilevel analysis with data integration on biopsies with a range of disease involvement identifies important features of the evolving tumor microenvironment. The data suggest that despite the large spectrum of genomic alterations, some human malignancies may have a common and potentially targetable matrix response that influences the course of disease. Cancer Discov; 8(3); 304-19. ©2017 AACR.This article is highlighted in the In This Issue feature, p. 253

Developments in high energy theory

This non-technical review article is aimed at readers with some physics background, including beginning research students. It provides a panoramic view of the main theoretical developments in high energy physics since its inception more than half a century ago, a period in which experiments have spanned an enormous range of energies, theories have been developed leading up to the Standard Model, and proposals -- including the radical paradigm of String Theory -- have been made to go beyond the Standard Model. The list of references provided here is not intended to properly credit all original work but rather to supply the reader with a few pointers to the literature, specifically highlighting work done by Indian authors.Comment: 52 pages, 14 figures, corrected versio

<i>ABCB1</i> (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

BACKGROUND: Clinical response to chemotherapy for ovarian cancer is frequently compromised by the development of drug-resistant disease. The underlying molecular mechanisms and implications for prescription of routinely prescribed chemotherapy drugs are poorly understood. METHODS: We created novel A2780-derived ovarian cancer cell lines resistant to paclitaxel and olaparib following continuous incremental drug selection. MTT assays were used to assess chemosensitivity to paclitaxel and olaparib in drug-sensitive and drug-resistant cells±the ABCB1 inhibitors verapamil and elacridar and cross-resistance to cisplatin, carboplatin, doxorubicin, rucaparib, veliparib and AZD2461. ABCB1 expression was assessed by qRT-PCR, copy number, western blotting and immunohistochemical analysis and ABCB1 activity assessed by the Vybrant and P-glycoprotein-Glo assays. RESULTS: Paclitaxel-resistant cells were cross-resistant to olaparib, doxorubicin and rucaparib but not to veliparib or AZD2461. Resistance correlated with increased ABCB1 expression and was reversible following treatment with the ABCB1 inhibitors verapamil and elacridar. Active efflux of paclitaxel, olaparib, doxorubicin and rucaparib was confirmed in drug-resistant cells and in ABCB1-expressing bacterial membranes. CONCLUSIONS: We describe a common ABCB1-mediated mechanism of paclitaxel and olaparib resistance in ovarian cancer cells. Optimal choice of PARP inhibitor may therefore limit the progression of drug-resistant disease, while routine prescription of first-line paclitaxel may significantly limit subsequent chemotherapy options in ovarian cancer patients