Recherche sur l'origine des fausses réactions positives dans le diagnostic sérologique de la péripneumonie contagieuse bovine

Des bovins ont été expérimentalement immunisés respectivement avec Mycoplasma (M) capricolum, M. mycoides subsp. mycoides (LC), M. mycoides subsp. capri, M. species groupe 7 de LEACH. Pendant 8 semaines ces animaux ont fait l'objet d'un suivi sérologique vis-à-vis de l'agent de la péripneumon ie contagieuse bovine (PPCB), par le test immunoenzymatique (ELISA), en fixation du complément (FC) et en hémagglutination passive (HAP), l'HAP étant effectuée également vis-à-vis des valences d'immunisation. En FC, utilisée selon la méthode standardisée, des réactions croisées, souvent transitoires, sont notées chez les bovins immunisés par le groupe 7 et les 2 "mycoides" caprins. Ce modèle experimental pourrait expliquer certaines réactions aspécifiques naturelles rencontrées exceptionnellement lors du diagnostic sérologique de la PPC

Unique presentation of a giant mediastinal tumor as kyphosis: a case report

<p>Abstract</p> <p>Introduction</p> <p>Although posture distortion is a common problem in elderly patients, spinal deformity caused by a thymoma has not been previously reported. Thymomas are slowly growing tumors that predominantly cause respiratory symptoms.</p> <p>Case presentation</p> <p>We report the case of an 83-year-old woman who was admitted with a giant mediastinal mass that had caused progressive spinal distortion and weight loss to our department. The clinical and laboratory investigations that followed revealed one of the largest thymomas ever reported in the medical literature, presenting as a mass lesion placed at the left hemithorax. She underwent complete surgical excision of the tumor via a median sternotomy. Two years after the operation, she showed significant improvement in her posture, no pulmonary discomfort, and a gain of 20 kg; she remains disease free based on radiographic investigations.</p> <p>Conclusions</p> <p>In this case, a chronic asymmetric load on the spine resulted in an abnormal vertebral curvature deformity that presented as kyphosis.</p

Reversal of childhood idiopathic scoliosis in an adult, without surgery: a case report and literature review

<p>Abstract</p> <p>Background</p> <p>Some patients with mild or moderate thoracic scoliosis (Cobb angle <50-60 degrees) suffer disproportionate impairment of pulmonary function associated with deformities in the sagittal plane and reduced flexibility of the spine and chest cage. Long-term improvement in the clinical signs and symptoms of childhood onset scoliosis in an adult, without surgical intervention, has not been documented previously.</p> <p>Case presentation</p> <p>A diagnosis of thoracic scoliosis (Cobb angle 45 degrees) with pectus excavatum and thoracic hypokyphosis in a female patient (DOB 9/17/52) was made in June 1964. Immediate spinal fusion was strongly recommended, but the patient elected a daily home exercise program taught during a 6-week period of training by a physical therapist. This regime was carried out through 1992, with daily aerobic exercise added in 1974. The Cobb angle of the primary thoracic curvature remained unchanged. Ongoing clinical symptoms included dyspnea at rest and recurrent respiratory infections. A period of multimodal treatment with clinical monitoring and treatment by an osteopathic physician was initiated when the patient was 40 years old. This included deep tissue massage (1992-1996); outpatient psychological therapy (1992-1993); a daily home exercise program focused on mobilization of the chest wall (1992-2005); and manipulative medicine (1994-1995, 1999-2000). Progressive improvement in chest wall excursion, increased thoracic kyphosis, and resolution of long-standing respiratory symptoms occurred concomitant with a >10 degree decrease in Cobb angle magnitude of the primary thoracic curvature.</p> <p>Conclusion</p> <p>This report documents improved chest wall function and resolution of respiratory symptoms in response to nonsurgical approaches in an adult female, diagnosed at age eleven years with idiopathic scoliosis.</p

Effect of Recovery Duration on Muscular Power and Blood Lactate During the Bench Press Exercise

International audienceIn order to assess the effect of recovery on power and blood lactate, 10 males performed 10 sets (S1 to S10) of 6 repetitions of bench press at 70% of their maximal strength, with 1 (Prot1), 3 (Prot3) or 5 (Prot5) min rest between sets. From the measurements of force and displacement of the bar, mean power during each repetition (MPR) and set (MPS), were calculated. Blood lactate was evaluated before and immediately after each set. No significant variations in power or blood lactate occurred during prot3 and prot5. From S4 to S10, significantly lower MPS (27% decrease) and higher blood lactate (7.6 +/- 2.0 mmol/l) were demonstrated in prot1 vs prot3 or prot5. In spite of this, MPR in protl were significantly lower for repetitions 4, 5 and 6 only: MPR of repetitions 1, 2 and 3 were similar in the 3 protocols. During prot1 only, power decrease was related to lactate accumulation for all subjects (0.64 &lt; or = r &lt; or = 0.99, p &lt; or = 0.05). These results indicate that although muscular power and blood lactate were both affected by the recovery interval, acidosis was not the direct cause of fatigue during the 1 min rest condition. The concomitant effects of lactate accumulation and insufficient time for a complete resynthesis may have resulted in a diminution of PCr stores, leading to power decrements

Reproduction expérimentale et évolution de la péripneumonie contagieuse bovine dans un groupe de bovins et de caprins : aspects anatomocliniques

Cinq bovins ont été inoculés par voie endobronchique avec une culture de Mycoplasma mycoides subsp. mycoides "small colony" (M.m.m. SC), et ont été entretenus en contact étroit avec 5 autres bovins et 5 caprins. Sur une période de 4 mois, ces animaux ont fait l'objet de suivis clinique et sérologique, ainsi que, pour les bovins, d'un suivi de l'excrétion de M.m.m. CS. A terme, ils ont été abattus et autopsiés. Sur cette période, les caprins n'ont présenté aucun symptôme, aucune lésion et aucune réaction sérologique. En revanche, tous les bovins se sont infectés, mais la maladie a pris dans ce foyer de péripneumonie pure des aspects très polymorphes : une forme subclinique avec excrétion massive et prolongée évoluant de façon chronique avec des lésions typiques à l'abattage chez tous les témoins-contacts; une forme aiguë mortelle avec excrétion massive et lésions étendues chez un inoculé; une forme latente avec excrétion prolongée mais sans lésions macroscopiques à l'abattage chez les autres inoculés