The electronic structure of the Nax_xCoO2_2 surface

The idea that surface effects may play an important role in suppressing $e_g'$ Fermi surface pockets on Na$_x$CoO$_2$ $(0.333 \le x \le 0.75)$ has been frequently proposed to explain the discrepancy between LDA calculations (performed on the bulk compound) which find $e_g$' hole pockets present and ARPES experiments, which do not observe the hole pockets. Since ARPES is a surface sensitive technique it is important to investigate the effects that surface formation will have on the electronic structure of Na$_{1/3}$CoO$_2$ in order to more accurately compare theory and experiment. We have calculated the band structure and Fermi surface of cleaved Na$_{1/3}$CoO$_2$ and determined that the surface non-trivially affects the fermiology in comparison to the bulk. Additionally, we examine the likelihood of possible hydroxyl cotamination and surface termination. Our results show that a combination of surface formation and contamination effects could resolve the ongoing controversy between ARPES experiments and theory.Comment: 4 pages, 2 figure

The origin of a1g_{1g} and eg_g' orderings in Nax_xCoO2_2

It has often been suggested that correlation effects suppress the small e_g' Fermi surface pockets of NaxCoO_2 that are predicted by LDA, but absent in ARPES measurements. It appears that within the dynamical mean field theory (DMFT) the ARPES can be reproduced only if the on-site energy of the eg' complex is lower than that of the a1g complex at the one-electron level, prior to the addition of local correlation effects. Current estimates regarding the order of the two orbital complexes range from -200 meV to 315 meV in therms of the energy difference. In this work, we perform density functional theory calculations of this one-electron splitting \Delta= \epsilon_a1g-\epsilon_e_g' for the full two-layer compound, Na2xCo2O4, accounting for the effects of Na ordering, interplanar interactions and octahedral distortion. We find that \epsilon a_1g-\epsilon e_g' is negative for all Na fillings and that this is primarily due to the strongly positive Coulomb field created by Na+ ions in the intercalant plane. This field disproportionately affects the a_1g orbital which protrudes farther upward from the Co plane than the e_g' orbitals. We discuss also the secondary effects of octahedral compression and multi-orbital filling on the value of \Delta as a function of Na content. Our results indicate that if the e_g' pockets are indeed suppressed that can only be due to nonlocal correlation effects beyond the standard DMFT.Comment: 4 pages, 3 figure

Measurement of a topological edge invariant in a microwave network

We report on the measurement of topological invariants in an electromagnetic topological insulator analog formed by a microwave network, consisting of the winding numbers of scattering matrix eigenvalues. The experiment can be regarded as a variant of a topological pump, with non-zero winding implying the existence of topological edge states. In microwave networks, unlike most other systems exhibiting topological insulator physics, the winding can be directly observed. The effects of loss on the experimental results, and on the topological edge states, is discussed.Comment: 10 pages, 10 figure

The art of HIV elimination: past and present science

Introduction: Remarkable strides have been made in controlling the HIV epidemic, although not enough to achieve epidemic control. More recently, interest in biomedical HIV control approaches has increased, but substantial challenges with the HIV cascade of care hinder successful implementation. We summarise all available HIV prevention methods and make recommendations on how to address current challenges. Discussion: In the early days of the epidemic, behavioural approaches to control the HIV dominated, and the few available evidence-based interventions demonstrated to reduce HIV transmission were applied independently from one another. More recently, it has become clear that combination prevention strategies targeted to high transmission geographies and people at most risk of infections are required to achieve epidemic control. Biomedical strategies such as male medical circumcision and antiretroviral therapy for treatment in HIV-positive individuals and as preexposure prophylaxis in HIV-negative individuals provide immense promise for the future of HIV control. In resourcerich settings, the threat of HIV treatment optimism resulting in increased sexual risk taking has been observed and there are concerns that as ART roll-out matures in resource-poor settings and the benefits of ART become clearly visible, behavioural disinhibition may also become a challenge in those settings. Unfortunately, an efficacious vaccine, a strategy which could potentially halt the HIV epidemic, remains elusive. Conclusion: Combination HIV prevention offers a logical approach to HIV control, although what and how the available options should be combined is contextual. Therefore, knowledge of the local or national drivers of HIV infection is paramount. Problems with the HIV care continuum remain of concern, hindering progress towards the UNAIDS target of 90-90-90 by 2020. Research is needed on combination interventions that address all the steps of the cascade as the steps are not independent of each other. Until these issues are addressed, HIV elimination may remain an unattainable goal

Connected OFCity Challenge: Addressing the Digital Divide in the Developing World

Over the past 50 years, the development of information and communications technology has provided unprecedented support to the steady economic growth of developed countries. In recent years, some of the largest growth has been reported in emerging economies, which, however, often lack adequate telecommunications infrastructure to further sustain their development. Although a number of service providers and system vendors have started to address the issue, the challenges they encounter are substantially different from those in the developed world, including an unreliable electricity grid, poor fiber infrastructure, low revenue expectations, and often a harsh climate environment. This paper reports use cases and solutions pertinent to the development of the networking infrastructure in emerging economies, provided by organizations directly involved in such activities. After providing some background information on the current state of network infrastructure and the main challenges for Africa and rural China, the paper provides details on two proposed solutions. The first focuses on the provisioning of services and network infrastructure through the development of low-cost data centers, whereas the second proposes cost-effective adaptation of both fiber and hybrid copper-fiber technology to rural areas. The article is concluded with a brief discussion on the complementarity of the two approaches

Sequential CCR5-Tropic HIV-1 Reactivation from Distinct Cellular Reservoirs following Perturbation of Elite Control

Background HIV Elite Controllers may reveal insights into virus persistence given they harbour small reservoir sizes, akin to HIV non-controllers treated early with combination antiretroviral therapy. Both groups of patients represent the most promising candidates for interventions aimed at sustained remission or ‘cure’. Analytic treatment interruption (ATI) in the latter group leads to stochastic rebound of virus, though it is unclear whether loss of elite control is also associated with similar rebound characteristics. Methods We studied three discrete periods of virus rebound during myeloma related immune disruption over 2.5 years in an elite controller who previously underwent autologous stem cell transplantation (ASCT) in the absence of any antiretroviral therapy. Single genome sequencing of the V1-V4 region of env in PBMC and plasma was performed and phylogenies reconstructed. Average pairwise distance (APD) was calculated and non-parametric methods used to assess compartmentalisation. Coreceptor usage was predicted based on genotypic algorithms. Results 122 single genome sequences were obtained (median 26 sequences per rebound). The initial rebounding plasma env sequences following ASCT represented two distinct lineages, and clustered with proviral DNA sequences isolated prior to ASCT. One of the lineages was monophyletic, possibly indicating reactivation from clonally expanded cells. The second rebound occurred 470 days after spontaneous control of the first rebound and was phylogenetically distinct from the first, confirmed by compartmentalisation analysis, with a different cellular origin rather than ongoing replication. By contrast, third rebound viruses clustered with second rebound viruses, with evidence for ongoing evolution that was associated with lymphopenia and myeloma progression. Following ASCT a shift in tropism from CXCR4-tropic viruses to a CCR5-tropic population was observed to persist through to the third rebound. Conclusions Our data highlight similarities in the viral reservoir between elite and non-controllers undergoing ATI following allogeneic transplantation. The lack of propagation of CXCR4 using viruses following transplantation warrants further study

Splitting fields and general differential Galois theory

An algebraic technique is presented that does not use results of model theory and makes it possible to construct a general Galois theory of arbitrary nonlinear systems of partial differential equations. The algebraic technique is based on the search for prime differential ideals of special form in tensor products of differential rings. The main results demonstrating the work of the technique obtained are the theorem on the constructedness of the differential closure and the general theorem on the Galois correspondence for normal extensions..Comment: 33 pages, this version coincides with the published on

Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017.

We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity

Measurement of fraction unbound paclitaxel in human plasma

The clinical pharmacokinetic behavior of paclitaxel (Taxol) is distinctly nonlinear, with disproportional increases in systemic exposure with an increase in dose. We have recently shown that Cremophor EL, the formulation vehicle used for i.v. administration of paclitaxel, alters drug distribution as a result of micellar entrapment of paclitaxel, and we speculated that the free drug fraction (fu) is dependent on dose and time-varying concentrations of Cremophor EL in the central plasma compartment. To test this hypothesis, a reproducible equilibrium dialysis method has been developed for the measurement of paclitaxel fu in plasma. Equilibrium dialysis was performed at 37 degrees C in a humidified atmosphere of 5% CO(2) using 2.0-ml polypropylene test tubes. Experiments were carried out with 260-microliter aliquots of plasma containing a tracer amount of [G-(3)H]paclitaxel with high-specific activity against an equal volume of 0.01 M phosphate buffer (pH 7.4). Drug concentrations were measured by both reversed-phase HPLC and liquid scintillation counting. Using this method, fu has been measured in three patients receiving three consecutive 3-weekly courses of paclitaxel at dose levels of 135, 175, and 225 mg/m(2) and found to range between 0.036 and 0.079. The method was also used to define concentration-time profiles of unbound drug, estimated from the product of the total plasma concentration and fu