375 research outputs found
Selective inhibition of cholesterol synthesis by cell-free preparations of rat liver by using inhibitors of cytoplasmic acetoacetyl-coenzyme A thiolase.
Specific labelling of a constituent polypeptide of bovine heart mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone reductase by the inhibitor diphenyleneiodonium
Identification of cysteine as the reactive group in pyruvate kinase alkylated by 5-chloro-4-oxopentanoic acid
A detailed investigation of the properties of lactate dehydrogenase in which the ‘Essential’ cysteine-165 is modified by thioalkylation
Struggling and juggling: a comparison of assessment loads in research and teaching-intensive universities
In spite of the rising tide of metrics in UK higher education, there has been scant attention paid to assessment loads, when evidence demonstrates that heavy demands lead to surface learning. Our study seeks to redress the situation by defining assessment loads and comparing them across research-and teaching intensive universities. We clarify the concept of ‘assessment load’ in response to findings about high volumes of summative assessment on modular degrees. We define assessment load across whole undergraduate degrees, according to four measures: the volume of summative assessment; volume of formative assessment; proportion of examinations to coursework; number of different varieties of assessment. All four factors contribute to the weight of an assessment load, and influence students’ approaches to learning. Our research compares programme assessment data from 73 programmes in 14 UK universities, across two institutional categories. Research-intensives have higher summative assessment loads and a greater proportion of examinations; teaching-intensives have higher varieties of assessment. Formative assessment does not differ significantly across both university groups. These findings pose particular challenges for students in different parts of the sector. Our study questions the wisdom that ‘more’ is always better, proposing that lighter assessment loads may make room for ‘slow’ and deep learning
Time-variation of Jupiter's internal magnetic field consistent with zonal wind advection
Determination of the time dependency (secular variation) of a planet’s magnetic field provides a window into understanding the dynamo responsible for generating its field. However, of the six Solar System planets with active dynamos, secular variation has been firmly established only for Earth. Here, we compare magnetic field observations of Jupiter from the Pioneer 10 and 11, Voyager 1 and Ulysses spacecraft (acquired 1973–1992) with a new Juno reference model (JRM09). We find a consistent, systematic change in Jupiter’s field over this 45-year time span, which cannot be explained by changes in the magnetospheric field or by changing the assumed rotation rate of Jupiter. Through a simplified forward model, we find that the inferred change in the field is consistent with advection of the field by Jupiter’s zonal winds, projected down to 93–95% of Jupiter’s radius (where the electrical conductivity of the hydrogen envelope becomes sufficient to advect the field). This result demonstrates that zonal wind interactions with Jupiter’s magnetic field are important and lends independent support to atmospheric and gravitational-field determinations of the profile of Jupiter’s deep winds
Core-mantle boundary deformations and J2 variations resulting from the 2004 Sumatra earthquake
The deformation at the core-mantle boundary produced by the 2004 Sumatra
earthquake is investigated by means of a semi-analytic theoretical model of
global coseismic and postseismic deformation, predicting a millimetric
coseismic perturbation over a large portion of the core-mantle boundary.
Spectral features of such deformations are analysed and discussed. The
time-dependent postseismic evolution of the elliptical part of the gravity
field (J2) is also computed for different asthenosphere viscosity models. Our
results show that, for asthenospheric viscosities smaller than 10^18 Pa s, the
postseismic J2 variation in the next years is expected to leave a detectable
signal in geodetic observations.Comment: 14 pages, 8 figures, 1 table. It will appear in Geophysical Journal
Internationa
Neutron-hole strength in the N = 81 isotones
The distribution of neutron-hole strength has been studied in the N 81 isotones 137Ba, 139Ce, 141Nd and 143Sm through the single-neutron removing reactions (p,d) and ( 3He,α), at energies of 23 and 34 MeV, respectively. Systematic cross section measurements were made at angles sensitive to the transferred angular momentum, and spectroscopic factors extracted through a distorted-wave Born approximation analysis. Application of the MacFarlane-French sum rules indicate an anomalously low summed g7/2 spectroscopic factor, most likely due to extensive fragmentation of the single-particle strength. Single-particle energies, based upon the centroids of observed strength, are presented. © Published under licence by IOP Publishing Ltd
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