Encapsulation of water insoluble drugs in mesoporous silica nanoparticles using supercritical carbon dioxide

Mesoporous silica nanoparticles MCM – 41 were synthesized with two dimensional hexagonal p6mm symmetry, high specific surface area(~ 980m2/g) narrow pore size and an average particle size of 186 nm. The produced nanoparticles were used to encapsulate carbamazepine through a supercritical carbon dioxide process combined with various organic solvents. Supercritical processing was found to provide increased drug encapsulation. The loaded MCM - 41 nanoparticles were analyzed using X–ray diffraction and differential scanning calorimetry (DSC) to investigate the crystalline state of the encapsulated carbamazepine and it was found to be dependent on the nature of the organic solvent. Carbamazepine showed increased dissolution rates under sink conditions. Viability studies of Caco – 2 cells demonstrated negligible cytotoxicity for the MCM–41 nanoparticles

KALYANAKARAKAM – A GEM OF AYURVEDA

Background: The origin of Ayurveda is lost in mysteries of time; since the earliest human civilization, man has sought ways to heal himself. Human civilization progressed, bringing in sophisticated thought & research behind medicine. It is believed that a system of medicine was prevalent in India in pre Vedic times. The Vedas are the earliest written records of the wisdom & insights of Indian seekers & scholars. Medicine is an ever changing science. Literary research is must in today’s perspective to get the hidden & unexplored knowledge. On this regard many Acharya’s contributed to ancient science i.e. Ayurveda. Jain seers have written several texts in Sanskrit on Ayurveda they are similar in content & finding to Vedic text. One among them is Kalyanakarakam, was composed by Acarya Ugraditya, a Jain monk who is believed to have lived in the 9th century of the Common Era. This text comprises of 667 Sanskrit hemistich divided into 25 chapters and one special section on predicting death. The chapters cover all aspects of Ayurveda with great depth and thoroughness. Aims & Objective: 1) To compile the literature bearing Svastha Rakshana i.e. preventive aspects in the form of Dinacharya (daily regimen), Rutu-charya (seasonal regimen) etc. &some other concepts like knowledge about Prakruti (nature) Desha (region), Kala (time), important anatomical structures, and regimens for pregnant women etc. Materials & Methods: Study aims to review the preventive aspects which are mentioned in Kalyanakarakam. Conclusion: Inculcating all the concepts which elucidates the concept of prevention is much essential in today’s perspective

Sciatica (Gridhrasi) - An Ayurveda Perspective

Large number of population suffers from low back pain. Chronic low back pain (CLBP) prevalence increases linearly from the third decade of life on, until the 60 years of age, being more prevalent in women. Sciatica is the most common debilitating condition causes CLBP. Radiating leg pain and related disabilities are the observed in sciatica. Nearly 40% people experience sciatic pain at some point in their life. The diagnosis of sciatica and its management varies considerably within and between countries. Conventional Medicine and surgery are widely used in the management of sciatica. There is radical rise in the use of Complementary and Alternative Medicine (CAM) in patients with sciatica. Ayurveda is one of the widely used CAM in the recent past. Sciatica resembles the disease Gridharsi of Ayurveda. Gridharsi is one among the Vataja nanatmaja vyadhi, where dysfunction of Vata affect gridharsi nadi characterized by low back pain radiating to lower limbs, stiffness and pricking type of pain. It starts from kati- prishta (pelvic region and Lumbosacral) radiating to jangha paada (Thigh, Feets) with impairment of lifting the leg. The gait of the person is very similar to vulture (Gridhra) hence the name is given as Gridharsi. In this article, attempt has been made to review the Ayurvedic classics text and related literatures to understand the disease Gridharsi with emphasis on its samprapti on the basis of Kriyakala and role of Shodhana and Shamana chikitsa in the management of Gridharsi

Proximate analysis and mineral characterization of Barringtonia species

The study about material contained in Barringtonia seeds were conducted at the first time using the standard procedure of AOAC. For present work, two species of Barringtonia were selected viz., B. acutangula and B. racemosa . The proximate composition and mineral constituents of Barringtonia seeds were evaluated. The B. acutangula seeds contained ash 4.24%, crude protein 9.23%, crude lipids 0.68%, crude fibre13.54% and carbohydrates 66.17%. While in seeds of B. racemosa, ash 4.02%, crude protein 12.09%, crude lipids 0.75%, crude fibre15.18% and carbohydrates: 64.67% were observed. Both the species have a high energy value on dry basis. Comparing the mineral content with recommended dietary allowances (RDA), the results indicated that seeds of B. acutangula fruits could be a good supplement for some nutrients such as calcium, fibre and carbohydrates, whereas the B. racemosa seeds could be a good supplement for some nutrients such as fibre, potassium, zinc and carbohydrates. The seeds of Barringtonia could be promoted as a carbohydrate supplement. Hence, this piece of work acclaims the potential of Barringtonia species indicating its proximate and mineral composition

Statistical Assertions for Validating Patterns and Finding Bugs in Quantum Programs

In support of the growing interest in quantum computing experimentation, programmers need new tools to write quantum algorithms as program code. Compared to debugging classical programs, debugging quantum programs is difficult because programmers have limited ability to probe the internal states of quantum programs; those states are difficult to interpret even when observations exist; and programmers do not yet have guidelines for what to check for when building quantum programs. In this work, we present quantum program assertions based on statistical tests on classical observations. These allow programmers to decide if a quantum program state matches its expected value in one of classical, superposition, or entangled types of states. We extend an existing quantum programming language with the ability to specify quantum assertions, which our tool then checks in a quantum program simulator. We use these assertions to debug three benchmark quantum programs in factoring, search, and chemistry. We share what types of bugs are possible, and lay out a strategy for using quantum programming patterns to place assertions and prevent bugs.Comment: In The 46th Annual International Symposium on Computer Architecture (ISCA '19). arXiv admin note: text overlap with arXiv:1811.0544

Remote Video Monitoring System Using Raspberry Pi 3 and GPRS Module

Now a day’s security has prime importance in different areas such as home security, monitoring of remote areas etc. with advancement in embedded system and wireless technology, it is possible to build a remote area monitoring system with low cost. This paper represents a system implemented by using Raspberry Pi 3 and GPRS module. Transmitter section is implemented at remote area where images are captured by using USB camera interfaced with Raspberry pi. Images are compressed by software programming using libjpeg library and uploaded to HTTP server via SIM900A/800 GSM/GPRS module. Internet connection is established using PPP stack of SIM900A/800 GSM/GPRS module. Receiver section is monitoring center where images are downloaded using 3g or Wi-Fi wireless connection. Received images are decompressed and streamed on web browser using MJPG streamer

Proof Verification and Attribute Based Re-Encryption of Shared Data over Public Cloud

Cloud storage is the best and proficient approach to handle our information remotely. In any case, since information proprietors and clients are more often than not outside the trusted area of cloud specialist co-ops the information security and get to control is the critical component at the season of delicate information put away in the cloud. Additionally, now days there are distinctive systems are accessible for information sharing and saving security of information proprietor and client. Key Escrow is the one of the significant issue now a day. We can’t keep full trust over the key power focus since they might be abuse their benefits. This is unsatisfactory for data sharing circumstances. In this paper we concentrated the current procedure for sharing the information from information proprietor to information client. The methodology propose an enhanced two-party key issuing convention that can ensure that neither key power nor cloud specialist co-op can bargain the entire mystery key of a client exclusively. The method also present the idea of quality with weight, being given to upgrade the statement of characteristic, which cannot just extend the expression from paired to discretionary state, additionally help the intricacy of get to approach. In this manner, both capacity cost and encryption many-sided quality for a cipher text are eased. Attribute based encryption is an open key based encryption that empowers get to control over encoded information utilizing access strategies and credited qualities. In this paper we propose proof verification module which verify proof of shared file and is received by data consumer when file shared by data owner and also a method which applies re-encryption (ABE) of a shared file here the attributes of data consumers are used to generate key

Solvent Effect on Fluorescence Quenching of 7, 8 Benzo‑4‑azido Methyl Coumarin by Aniline

Fluorescence quenching of biologically active studies of 7, 8 benzo-4-azidomethyl coumarin (7BAMC) by aniline in four different organic solvents namely benzene, dioxane, tetrahydrofuran and acetonitrile has been carried out at room temperature with a view to understand the quenching mechanisms. The Stern–Volmer (S-V) plot has been found to be non-linear with a positive deviation for all the solvents studied. In order to interpret these results we have invoked the ground state complex formation and sphere of action static quenching models. Using these models various quenching rate parameters have been determined. The magnitudes of these parameters suggest that sphere of action static quenching model agrees well with the experimental results. Hence the positive deviation is attributed to the static and dynamic quenching. Further, with the use of Finite Sink approximation model, it was possible to check these bimolecular reactions as diffusion-limited and to estimate independently distance parameter R’ and mutual diffusion coefficient D. Finally an effort has been made to correlate the values of R’ and D with the values of the encounter distance R and the mutual coefficient D determined using the Edward’s empirical relation and Stokes – Einstein relation

MANGO STARCH: ITS USE AND FUTURE PROSPECTS

Mango (Mangifera indica L.) is tropical fruit with high nutritional value. The aim of present work was to isolate the starch from black variety of mango and evaluate the physicochemical as well as functional properties. Starch is widely used in the food and pharmaceutical industries for various applications. These industries depend on crops that are also the traditional sources of food resulting high demands with consequence economic implications. The results showed that the moisture content (14.93%) was higher while ash content (0.12%) was low. Amylose content was 35.06%. It was observed that the onset gelatinization temperature of the starch ranged from 50°C whereas, the conclusion gelatinization temperature was from 91-92.5°C. The starch show adequate properties and could be alternative source for the production of industrial products that may require starch.Â