m6a RNA methylation: the implications for health and disease

The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification. The m6a modification is a highly reactive and fluid modification which can respond rapidly to a broad variety of stimuli, and translate these signals into cellular activity. The little information that has been established on its functional capacity has opened up many new avenues of research and has tremendous implications for several fields of study. Here we outline the breakthroughs which have led to the resurgence of interest in this modification and discuss the effects and potential they represent in terms of control in the immune system, viral replication and infection, as well as the occurrence and progression of cancer

Sirtuins, bioageing, and cancer

The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins are heavily implicated in cell cycle, cell division, transcription regulation, and metabolism, which places the various family members at critical junctures in cellular metabolism. Typically, Sirtuins have been implicated in the preservation of genomic stability and in the prolongation of lifespan though many of their target interactions remain unknown. Sirtuins play key roles in tumourigenesis, as some have tumour-suppressor functions and others influence tumours through their control of the metabolic state of the cell. Their links to ageing have also highlighted involvement in various age-related and degenerative diseases. Here, we discuss the current understanding of the role of Sirtuins in age-related diseases while taking a closer look at their roles and functions in maintaining genomic stability and their influence on telomerase and telomere function

The rescaling of sub-national planning: Can localism resolve England’s spatial planning conundrum?

This paper analyses the recent reorganisation of sub-national planning in England. The abrupt termination in 2010 of regional spatial strategies (RSSs) left England as the only major country in north-western Europe without effective sub-national governance structures (outside London) for spatial planning. Drawing on in-depth interviews with public-sector planners and other research material, this paper analyses the impacts of the demise of regional planning for ‘larger-than-local’ policy coordination in England. The paper seeks to question whether localism can succeed where regionalism is perceived to have failed in dealing effectively with the strategic spatial dilemmas integral to planning. It concludes by assessing whether the evolving decentralised forms of sub-national governance (combined authorities and local enterprise partnerships (LEPs)) emerging through the government’s ‘devolution revolution’ can develop to fill the current strategic planning void and resurrect some form of spatial planning throughout England