Are there socioeconomic gradients in stage and grade of breast cancer at diagnosis? Cross sectional analysis of UK cancer registry data

Socioeconomic gradients in uptake of breast cancer screening in the United Kingdom should, intuitively, lead to socioeconomic gradients in disease progression at diagnosis. However, studies have found little evidence of such an effect. Although this could be interpreted as evidence that socioeconomic gradients in uptake of screening do not have clinically important consequences, all of the published studies have used data from before (pre-1988) or during the early stages (1988-95) of implementation of the national breast cancer screening programme. We investigated the relation between socioeconomic position and progression of breast cancer at diagnosis by using recent data from the Northern and Yorkshire Cancer Registry and Information Service (NYCRIS), which is estimated to achieve around 93% ascertainment

Assembly Bias and Splashback in Galaxy Clusters

We use publicly available data for the Millennium Simulation to explore the implications of the recent detection of assembly bias and splashback signatures in a large sample of galaxy clusters. These were identified in the SDSS/DR8 photometric data by the redMaPPer algorithm and split into high- and low-concentration subsamples based on the projected positions of cluster members. We use simplified versions of these procedures to build cluster samples of similar size from the simulation data. These match the observed samples quite well and show similar assembly bias and splashback signals. Previous theoretical work has found the logarithmic slope of halo density profiles to have a well-defined minimum whose depth decreases and whose radius increases with halo concentration. Projected profiles for the observed and simulated cluster samples show trends with concentration which are opposite to these predictions. In addition, for high-concentration clusters the minimum slope occurs at significantly smaller radius than predicted. We show that these discrepancies all reflect confusion between splashback features and features imposed on the profiles by the cluster identification and concentration estimation procedures. The strong apparent assembly bias is not reflected in the three-dimensional distribution of matter around clusters. Rather it is a consequence of the preferential contamination of low-concentration clusters by foreground or background groups.Comment: 17 pages, 16 figures, 3 tables, accepted versio

How Rare is the Bullet Cluster?

The galaxy cluster 1E 0657-56 has a bullet-like subcluster that is moving away from the centre of the main cluster at high speed. Markevitch et al. (2004) recently estimated a relative velocity of V_bullet = 4500 +1100/-800 km/s, based on observations of the bow shock in front of the subcluster. The weak lensing analysis of Clowe et al. (2004) indicates that a substantial secondary mass peak is associated with this subcluster. We estimate the likelihood of such a configuration by examining the distribution of subhalo velocities for clusters in the Millennium Run, a large LCDM cosmological simulation. We find that the most massive subhalo has a velocity as high as that of the bullet subcluster in only about 1 out of every 100 cluster-sized halos. This estimate is strongly dependent on the precise velocity adopted for the bullet. One of the ten most massive subhalos has such a high velocity about 40% of the time. We conclude that the velocity of the bullet subcluster is not exceptionally high for a cluster substructure, and can be accommodated within the currently favoured LCDM comogony.Comment: 5 pages, 3 figures, accepted for publication in MNRA

Development of a super ductile diecast Al-Mg-Si alloy

This is the post-print version of the final paper published in Materials Science and Engineering A. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2012 Elsevier B.V.The super ductile diecast aluminium alloys have been developed particularly for application in automotive body structure. On the basis of the reviewing aluminium alloys currently available, the requirement of diecast aluminium alloys is summarized and the Al-Mg-Si system is focused in the development. The effect of various alloying elements on the microstructure and the mechanical properties, such as yield strength, ultimate tensile strength and elongation is assessed. The optimized composition of the super ductile Al-Mg-Si alloy has been found to be at 5.0-5.5wt% Mg, 1.5-2.0wt% Si, 0.5-0.7wt% Mn, 0.15-0.2wt% Ti with Fe <0.25wt% for the best combination of strength and ductility, which shows 150MPa of yield strength, 300MPa of ultimate tensile strength, and 15% of elongation under as-cast condition. The paint baking hardenability of the optimized alloy is found to be insignificant. Less than a 10% increase in the yield strength was achieved, with a slight decrease in the elongation after aging at 180°C for 30min, which is a simulated process of paint baking. Cu is found to slightly increase the yield strength under the as-cast condition and after the heat treatment, but with a significant reduction in the ductility. Therefore, Cu should be limited in the super ductile aluminium alloy. The microstructure of diecast aluminium alloys at the optimized composition consists of the primary α-Al phase, the α-AlFeMnSi intermetallics and the Al-Mg Si eutectics. There are two types of primary α-Al phase: dendritic or fragmented dendritic α-Al phase solidified in the shot sleeve and globular α-Al particles solidified in the die cavity. The α-AlFeMnSi intermetallics is in the form of compact morphology and with a size of less than 3μm. The eutectic cells are at size of 10μm with a typical lamellar morphology of α-Al phase and Mg Si phase.EPSRC and JLRUK

Diffuse light in z~0.25 galaxy clusters: constraining tidal damage and the faint end of the Luminosity Function

The starlight coming from the intergalactic space in galaxy clusters and groups witnesses the violent tidal interactions that galaxies experience in these dense environments. Such interactions may be (at least partly) responsible for the transformation of normal star-forming galaxies into passive dwarf ellipticals (dEs). In this contribution we present the first systematic study of the IntraCluster Light (ICL) for a statistically representative sample (Zibetti et al. 2005), which comprises 683 clusters selected between z=0.2 and 0.3 from ~1500 deg^2 in the SDSS. Their ICL is studied by stacking the images in the g-, r-, and i-band after masking out all galaxies and polluting sources. In this way a very uniform background illumination is obtained, that allows us to measure surface brightnesses as faint as 31 mag/arcsec^2 and to trace the ICL out to 700 kpc from the central galaxy. We find that the local fraction of light contributed by intracluster stars rapidly decreases as a function of the clustercentric distance, from ~40% at 100 kpc to ~5% at 500 kpc. By comparing the distribution and colours of the ICL and of the clusters galaxies, we find indication that the main source of ICL are the stars stripped from galaxies that plunge deeply into the cluster potential well along radial orbits. Thus, if dEs are the remnants of these stripped progenitors we should expect similar radial orbital anisotropies and correlations between the dE luminosity function and the amount of ICL in different clusters. The diffuse emission we measure is contaminated by faint unresolved galaxies: this makes our flux estimate depend to some extent on the assumed luminosity function, but, on the other hand, allows us to constrain the number of faint galaxies. Our present results disfavour steep (alpha<-1.35) faint-end powerlaw slopes.Comment: 4 pages, 2 figures, use iauc.cls. Oral presentation to appear in the proceedings of "IAU Colloquium 198 - Near-Field Cosmology with Dwarf Elliptical Galaxies", Les Diablerets 14-18 March 2005, B. Binggeli and H. Jerjen ed