8,053 research outputs found
A Dependence of Hadron Production in Inelastic Muon Scattering and Dimuon Production by Protons
The A dependence of the production of hadrons in inelastic muon scattering
and of the production of dimuons in high proton interactions are simply
related. Feynman x distributions and z scaling distributions in nuclei are
compared with energy loss models. Suggestions for new data analyses are
presented.Comment: 14pp +13 figures, UPR report 607T (available from
ftp://dept.physics.upenn.edu/muhad
The Rab-binding profiles of bacterial virulence factors during infection
Legionella pneumophila, the causative agent of Legionnaire's disease, uses its type IV secretion system to translocate over 300 effector proteins into host cells. These effectors subvert host cell signaling pathways to ensure bacterial proliferation. Despite their importance for pathogenesis, the roles of most of the effectors are yet to be characterized. Key to understanding the function of effectors is the identification of host proteins they bind during infection. We previously developed a novel tandem-affinity purification (TAP) approach using hexahistidine and BirA-specific biotinylation tags for isolating translocated effector complexes from infected cells whose composition were subsequently deciphered by mass spectrometry. Here we further advanced the workflow for the TAP approach and determined the infection-dependent interactomes of the effectors SidM and LidA, which were previously reported to promiscuously bind multiple Rab GTPases in vitro. In this study we defined a stringent subset of Rab GTPases targeted by SidM and LidA during infection, comprising of Rab1A, 1B, 6, and 10; in addition, LidA targets Rab14 and 18. Taken together, this study illustrates the power of this approach to profile the intracellular interactomes of bacterial effectors during infection
Eigenvalue Separation in Some Random Matrix Models
The eigenvalue density for members of the Gaussian orthogonal and unitary
ensembles follows the Wigner semi-circle law. If the Gaussian entries are all
shifted by a constant amount c/Sqrt(2N), where N is the size of the matrix, in
the large N limit a single eigenvalue will separate from the support of the
Wigner semi-circle provided c > 1. In this study, using an asymptotic analysis
of the secular equation for the eigenvalue condition, we compare this effect to
analogous effects occurring in general variance Wishart matrices and matrices
from the shifted mean chiral ensemble. We undertake an analogous comparative
study of eigenvalue separation properties when the size of the matrices are
fixed and c goes to infinity, and higher rank analogues of this setting. This
is done using exact expressions for eigenvalue probability densities in terms
of generalized hypergeometric functions, and using the interpretation of the
latter as a Green function in the Dyson Brownian motion model. For the shifted
mean Gaussian unitary ensemble and its analogues an alternative approach is to
use exact expressions for the correlation functions in terms of classical
orthogonal polynomials and associated multiple generalizations. By using these
exact expressions to compute and plot the eigenvalue density, illustrations of
the various eigenvalue separation effects are obtained.Comment: 25 pages, 9 figures include
We Could, but Should We? Ethical Considerations for Providing Access to GeoCities and Other Historical Digital Collections
We live in an era in which the ways that we can make sense of our past are evolving as more artifacts from that past become digital. At the same time, the responsibilities of traditional gatekeepers who have negotiated the ethics of historical data collection and use, such as librarians and archivists, are increasingly being sidelined by the system builders who decide whether and how to provide access to historical digital collections, often without sufficient reflection on the ethical issues at hand. It is our aim to better prepare system builders to grapple with these issues. This paper focuses discussions around one such digital collection from the dawn of the web, asking what sorts of analyses can and should be conducted on archival copies of the GeoCities web hosting platform that dates to 1994.This research was supported by the Natural Sciences and Engineering Research Council of Canada, the Social Sciences and Humanities Research Council of Canada, the US National Science Foundation (grants 1618695 and 1704369), the Andrew W. Mellon Foundation, Start Smart Labs, and Compute Canada
Nonlinear equation for curved stationary flames
A nonlinear equation describing curved stationary flames with arbitrary gas
expansion , subject to the
Landau-Darrieus instability, is obtained in a closed form without an assumption
of weak nonlinearity. It is proved that in the scope of the asymptotic
expansion for the new equation gives the true solution to the
problem of stationary flame propagation with the accuracy of the sixth order in
In particular, it reproduces the stationary version of the
well-known Sivashinsky equation at the second order corresponding to the
approximation of zero vorticity production. At higher orders, the new equation
describes influence of the vorticity drift behind the flame front on the front
structure. Its asymptotic expansion is carried out explicitly, and the
resulting equation is solved analytically at the third order. For arbitrary
values of the highly nonlinear regime of fast flow burning is
investigated, for which case a large flame velocity expansion of the nonlinear
equation is proposed.Comment: 29 pages 4 figures LaTe
Geometric Parameterization of Absorption in Heavy Ion Collisions
We calculate the survival probability of particles in various
colliding systems using a Glauber model. An analysis of recent data has
reported a -nucleon breakup cross section of 6.20.7 mb derived
from an exponential fit to the ratio of to Drell-Yan yields as a
function of a simple, linearly-averaged mean path length through the nuclear
medium. Our calculations indicate that, due to the nature of the calculation,
this approach yields an apparent breakup cross section which is systematically
lower than the actual value.Comment: LaTex, 7 pages, 2 figure
Hodge Dual for Soldered Bundles
In order to account for all possible contractions allowed by the presence of
the solder form, a generalized Hodge dual is defined for the case of soldered
bundles. Although for curvature the generalized dual coincides with the usual
one, for torsion it gives a completely new dual definition. Starting from the
standard form of a gauge lagrangian for the translation group, the generalized
Hodge dual yields precisely the lagrangian of the teleparallel equivalent of
general relativity, and consequently also the Einstein-Hilbert lagrangian of
general relativity.Comment: 8 pages, no figures. Accepted for publication in Journal of Physics
N-terminal lipid modification is required for the stable accumulation of CyanoQ in Synechocystis sp. PCC 6803
© 2016 Juneau et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The CyanoQ protein has been demonstrated to be a component of cyanobacterial Photosystem II (PS II), but there exist a number of outstanding questions concerning its physical association with the complex. CyanoQ is a lipoprotein; upon cleavage of its transit peptide by Signal Peptidase II, which targets delivery of the mature protein to the thylakoid lumenal space, the N-terminal cysteinyl residue is lipid-modified. This modification appears to tether this otherwise soluble component to the thylakoid membrane. To probe the functional significance of the lipid anchor, mutants of the CyanoQ protein have been generated in Synechocystis sp. PCC 6803 to eliminate the N-terminal cysteinyl residue, preventing lipid modification. Substitution of the N-terminal cysteinyl residue with serine (Q-C22S) resulted in a decrease in the amount of detectable CyanoQ protein to 17% that of the wild-type protein. Moreover, the physical properties of the accumulated Q-C22S protein were consistent with altered processing of the CyanoQ precursor. The Q-C22S protein was shifted to a higher apparent molecular mass and partitioned in the hydrophobic phase in TX-114 phase-partitioning experiments. These results suggest that the hydrophobic N-terminal 22 amino acids were not properly cleaved by a signal peptidase. Substitution of the entire CyanoQ transit peptide with the transit peptide of the soluble lumenal protein PsbO yielded the Q-SS mutant and resulted in no detectable accumulation of the modified CyanoQ protein. Finally, the CyanoQ protein was present at normal amounts in the PS II mutant strains ΔpsbB and ΔpsbO, indicating that an association with PS II was not a prerequisite for stable CyanoQ accumulation. Together these results indicate that CyanoQ accumulation in Synechocystis sp. PCC 6803 depends on the presence of the N-terminal lipid anchor, but not on the association of CyanoQ with the PS II complex
Combining gravity with the forces of the standard model on a cosmological scale
We prove the existence of a spectral resolution of the Wheeler-DeWitt
equation when the underlying spacetime is a Friedman universe with flat spatial
slices and where the matter fields are comprised of the strong interaction,
with \SU(3) replaced by a general \SU(n), , and the electro-weak
interaction. The wave functions are maps from to a subspace of the
antisymmetric Fock space, and one noteworthy result is that, whenever the
electro-weak interaction is involved, the image of an eigenfunction is in
general not one dimensional, i.e., in general it makes no sense specifying a
fermion and looking for an eigenfunction the range of which is contained in the
one dimensional vector space spanned by the fermion.Comment: 53 pages, v6: some typos correcte
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