Variable stars in the globular cluster NGC 7492. New discoveries and physical parameters determination

We have performed a photometric V, R, I CCD time-series analysis with a baseline of ~8 years of the outer-halo globular cluster NGC 7492 with the aim of searching for new variables and using these (and the previously known variables) to determine the physical parameters of interest for the cluster (e.g. metallicity, absolute magnitude of the horizontal branch, distance, etc.). We use difference image analysis (DIA) to extract precise light curves in the relatively crowded star field, especially towards the densely populated central region. Several approaches are used for variability detection that recover the known variables and lead to new discoveries. We determine the physical parameters of the only RR0 star using light curve Fourier decomposition analysis. We find one new long period variable and two SX Phe stars in the blue straggler region. We also present one candidate SX Phe star which requires follow-up observations. Assuming that the SX Phe stars are cluster members and using the period-luminosity relation for these stars, we estimate their distances as ~25.2+-1.8 and 26.8+-1.8 kpc, and identify their possible modes of oscillation. We refine the periods of the two RR Lyrae stars in our field of view. We find that the RR1 star V2 is undergoing a period change and possibly exhibits the Blazhko effect. Fourier decomposition of the light curve of the RR0 star V1 allows us to estimate the metallicity [Fe/H]_ZW-1.68+-0.10 or [Fe/H]_UVES-1.64+-0.13, log-luminosity ~1.76+-0.02, absolute magnitude ~0.38+-0.04 mag, and true distance modulus of ~16.93+-0.04 mag, which is equivalent to a distance of ~24.3+-0.5 kpc. All of these values are consistent with previous estimates in the literature.Comment: 12 pages, 13 figures, 6 tables, accepted for publication in A&

Constraining the parameters of globular cluster NGC 1904 from its variable star population

We present the analysis of 11 nights of V and I time-series observations of the globular cluster NGC 1904 (M 79). Using this we searched for variable stars in this cluster and attempted to refine the periods of known variables, making use of a time baseline spanning almost 8 years. We use our data to derive the metallicity and distance of NGC 1904. We used difference imaging to reduce our data to obtain high-precision light curves of variable stars. We then estimated the cluster parameters by performing a Fourier decomposition of the light curves of RR Lyrae stars for which a good period estimate was possible. We also derive an estimate for the age of the cluster by fitting theoretical isochrones to our colour-magnitude diagram (CMD). Out of 13 stars previously classified as variables, we confirm that 10 are bona fide variables. We cannot detect variability in one other within the precision of our data, while there are two which are saturated in our data frames, but we do not find sufficient evidence in the literature to confirm their variability. We also detect a new RR Lyrae variable, giving a total number of confirmed variable stars in NGC 1904 of 11. Using the Fourier parameters, we find a cluster metallicity [Fe/H]_ZW=-1.63 +- 0.14, or [Fe/H]_UVES=-1.57 \pm 0.18, and a distance of 13.3 +- 0.4 kpc (using RR0 variables) or 12.9 kpc (using the one RR1 variable in our sample for which Fourier decomposition was possible).Comment: 14 pages, 11 figures, accepted for publication in A&

The unusually large population of Blazhko variables in the globular cluster NGC 5024 (M53)

We report the discovery of amplitude and phase modulations typical of the Blazhko effect in 22 RRc and 9 RRab type RR Lyrae stars in NGC 5024 (M53). This brings the confirmed Blazhko variables in this cluster to 23 RRc and 11 RRab, that represent 66% and 37% of the total population of RRc and RRab stars in the cluster respectively, making NGC 5024 the globular cluster with the largest presently known population of Blazhko RRc stars. We place a lower limit on the overall incidence rate of the Blazhko effect among the RR Lyrae population in this cluster of 52%. New data have allowed us to refine the pulsation periods. The limitations imposed by the time span and sampling of our data prevents reliable estimations of the modulation periods. The amplitudes of the modulations range between 0.02 and 0.39 mag. The RRab and RRc are neatly separated in the CMD, and the RRc Blazhko variables are on averge redder than their stable couterparts; these two facts may support the hypothesis that the HB evolution in this cluster is towards the red and that the Blazhko modulations in the RRc stars are connected with the pulsation mode switch.Comment: ACCEPTED IN MNRAS 14 pages, 9 figures and 6 table

Chemistry of 1-Fluoro-2,3,4-triphenylcyclobutadiene Dimers

The reaction of 2,4-dichloro-1,1-difluoro-3-phenyl-2-cyclobutene 1 with excess phenyllithium and subsequent transformations of the products have been reinvestigated. The phenyllithium reaction appears to proceed through the intermediacy of a fluorotriphenylcyclobutadiene 2 to produce a well-characterized dimeric trans-hexaphenyldifluorotricyclooctadiene 3a. Subsequent transformations of 3a gave a pentaphenyldihydrodifluoropentalene 4, which on acid hydrolysis formed a pentaphenyldihydropentalenone 5. When 3a was photolyzed in benzene, after purification, it afforded 6, an isomer of 5, probably by way of 7, an isomer of 4. Thermolysis of 3a also provided, in low yield, a substance believed to be a pentaphenylfluorophenanthrene 8. Along with isolation of 3a, and probably arising from a different isomer of the 3 family, was a pentaphenylfluorophenanthrene 9, which was suspected of being an isomer of 8. Single-crystal X-ray studies were used to derive structures for 4, 5, 6, and 9. Formation of the unusual and intriguing transformation products has at least been rationalized

Chemistry of 1-Fluoro-2,3,4-triphenylcyclobutadiene Dimers

The reaction of 2,4-dichloro-1,1-difluoro-3-phenyl-2-cyclobutene 1 with excess phenyllithium and subsequent transformations of the products have been reinvestigated. The phenyllithium reaction appears to proceed through the intermediacy of a fluorotriphenylcyclobutadiene 2 to produce a well-characterized dimeric trans-hexaphenyldifluorotricyclooctadiene 3a. Subsequent transformations of 3a gave a pentaphenyldihydrodifluoropentalene 4, which on acid hydrolysis formed a pentaphenyldihydropentalenone 5. When 3a was photolyzed in benzene, after purification, it afforded 6, an isomer of 5, probably by way of 7, an isomer of 4. Thermolysis of 3a also provided, in low yield, a substance believed to be a pentaphenylfluorophenanthrene 8. Along with isolation of 3a, and probably arising from a different isomer of the 3 family, was a pentaphenylfluorophenanthrene 9, which was suspected of being an isomer of 8. Single-crystal X-ray studies were used to derive structures for 4, 5, 6, and 9. Formation of the unusual and intriguing transformation products has at least been rationalized

Hypertrophic Stimulation Increases β-actin Dynamics in Adult Feline Cardiomyocytes

The myocardium responds to hemodynamic stress through cellular growth and organ hypertrophy. The impact of cytoskeletal elements on this process, however, is not fully understood. While α-actin in cardiomyocytes governs muscle contraction in combination with the myosin motor, the exact role of β-actin has not been established. We hypothesized that in adult cardiomyocytes, as in non-myocytes, β-actin can facilitate cytoskeletal rearrangement within cytoskeletal structures such as Z-discs. Using a feline right ventricular pressure overload (RVPO) model, we measured the level and distribution of β-actin in normal and pressure overloaded myocardium. Resulting data demonstrated enriched levels of β-actin and enhanced translocation to the Triton-insoluble cytoskeletal and membrane skeletal complexes. In addition, RVPO in vivo and in vitro hypertrophic stimulation with endothelin (ET) or insulin in isolated adult cardiomyocytes enhanced the content of polymerized fraction (F-actin) of β-actin. To determine the localization and dynamics of β-actin, we adenovirally expressed GFP-tagged β-actin in isolated adult cardiomyocytes. The ectopically expressed β-actin-GFP localized to the Z-discs, costameres, and cell termini. Fluorescence recovery after photobleaching (FRAP) measurements of β-actin dynamics revealed that β-actin at the Z-discs is constantly being exchanged with β-actin from cytoplasmic pools and that this exchange is faster upon hypertrophic stimulation with ET or insulin. In addition, in electrically stimulated isolated adult cardiomyocytes, while β-actin overexpression improved cardiomyocyte contractility, immunoneutralization of β-actin resulted in a reduced contractility suggesting that β-actin could be important for the contractile function of adult cardiomyocytes. These studies demonstrate the presence and dynamics of β-actin in the adult cardiomyocyte and reinforce its usefulness in measuring cardiac cytoskeletal rearrangement during hypertrophic stimulation

Mechanisms of Post-Stroke Fatigue: A Follow-Up From the Third Stroke Recovery and Rehabilitation Roundtable

Background Post-stroke fatigue (PSF) is a significant and highly prevalent symptom, whose mechanisms are poorly understood. The third Stroke Recovery and Rehabilitation Roundtable paper on PSF focussed primarily on defining and measuring PSF while mechanisms were briefly discussed. This companion paper to the main paper is aimed at elaborating possible mechanisms of PSF. Methods This paper reviews the available evidence that potentially explains the pathophysiology of PSF and draws parallels from fatigue literature in other conditions. We start by proposing a case for phenotyping PSF based on structural, functional, and behavioral characteristics of PSF. This is followed by discussion of a potentially significant role of early inflammation in the development of fatigue, specifically the impact of low-grade inflammation and its long-term systemic effects resulting in PSF. Of the many neurotransmitter systems in the brain, the dopaminergic systems have the most evidence for a role in PSF, along with a role in sensorimotor processing. Sensorimotor neural network dynamics are compromised as highlighted by evidence from both neurostimulation and neuromodulation studies. The double-edged sword effect of exercise on PSF provides further insight into how PSF might emerge and the importance of carefully titrating interventional paradigms. Conclusion The paper concludes by synthesizing the presented evidence into a unifying model of fatigue which distinguishes between factors that pre-dispose, precipitate, and perpetuate PSF. This framework will help guide new research into the biological mechanisms of PSF which is a necessary prerequisite for developing treatments to mitigate the debilitating effects of post-stroke fatigue