2,198 research outputs found
Innovations in Opioid Law and Policy Interventions Workshop: Summary of Proceedings
In 2017, Indiana University, in cooperation with Indiana Governor Eric Holcomb and community partners, launched the Grand Challenge: Responding to the Addictions Crisis initiative, a university-wide effort to advance interdisciplinary research and interventions in response to the substance abuse crisis affecting Indiana and the nation. The “Legal and Policy Best Practices in Response to the Substance Abuse Crisis” project is one of sixteen funded under Phase 1 of the Grand Challenge.
In July 2018, and as part of this project, the research team convened a group of national experts to discuss legal and policy innovations to respond to the opioid use disorder (OUD) crisis. This report summarizes the proceedings of this workshop and updates some of the recommendations made by the team in their March 2018 Preliminary Report.
During the workshop, experts answered targeted questions relating to the challenges in implementing law and policy recommendations to respond to the addiction crisis, as well as identified gaps in the current research. Participants provided examples of innovative interventions to respond to this crisis across four primary topic categories: (1) Criminalization; (2) Public Health; (3) Treatment; and (4) Effectuating Change
State statutes and regulations related to human papillomavirus vaccination
A cross-sectional analysis of human papillomavirus (HPV) vaccine statutes and regulations from states and the District of Columbia in the United States (U.S.) was conducted from September-November 2018 to advance analyses of policy impact on HPV vaccination uptake. A search was conducted using WestlawNext, a legal research database. Statutes and regulations relevant to the study were analyzed and coded based on their legal attributes into ten broad coding questions and several sub-questions. Of the 212 laws identified by the initial search string, 93 (43.9%) reference HPV vaccination in statute or regulation. An additional three laws were added following subsequent review. There was a total of 52 statutes and 44 regulations from 34 states and the District of Columbia. Most laws were related to developing and distributing HPV vaccination materials for parents, and mechanisms to fund and reimburse for the vaccination. This study can be used by policymakers in jurisdictions that are considering establishing HPV vaccination promotion interventions in state law and highlighting the limited statutory and regulatory efforts that have been implemented to promote HPV vaccination. Importantly, this study can also be used to conduct evaluations of the efficacy of statutory and regulatory strategies in increasing HPV vaccination rates
The potential impact of Ocean Thermal Energy Conversion (OTEC) on fisheries
The commercial development of ocean thermal energy conversion (OTEC) operations will involve some environmental perturbations for which there is no
precedent experience. The pumping of very large volumes of warm surface water and cold deep water and its subsequent discharge will result in the impingement, entrainment, and redistribution of biota. Additional stresses to biota will be caused by biocide usage and temperature depressions. However, the artificial upwelling of nutrients associated with the pumping of cold deep water, and the artificial
reef created by an OTEC plant may have positive effects on the local environment.
Although more detailed information is needed to assess the net effect of an OTEC operation on fisheries, certain assumptions and calculations are made supporting the conclusion that the potential risk to fisheries is not significant enough to deter the early development of IDEe. It will be necessary to monitor a commercial-scale plant in order to remove many of the remaining uncertainties. (PDF file contains 39 pages.
Shot noise in superconducting junctions with weak link formed by Anderson impurity
A theory is developed to study shot noise in superconducting (SAS) and hybrid
(SAN) junctions with singly occupied Anderson impurity (A) as a weak link. The
zero-frequency DC component of the shot noise spectral density is calculated at
zero temperature as a function of the bias at different Coulomb repulsion
strengths U, and show a remarkable structure resulting from combination of
electron-electron interaction and Andreev reflections.Comment: 4 two column pages including 4 .eps figure
Legal and Policy Best Practices in Response to the Substance Abuse Crisis: A Preliminary Report
In 2017, Indiana University, in cooperation with Indiana Governor Eric Holcomb and community partners, launched the Grand Challenge: Responding to the Addictions Crisis initiative, a university-wide effort to advance interdisciplinary research and interventions in response to the substance abuse crisis affecting Indiana and the nation. The “Legal and Policy Best Practices in Response to the Substance Abuse Crisis” project is one of sixteen funded under Phase 1 of the Grand Challenge. This preliminary report outlines the initial findings of the project
Subgap anomaly and above-energy-gap structure in chains of diffusive SNS junctions
We present the results of low-temperature transport measurements on chains of
superconductor--normal-constriction--superconductor (SNS) junctions fabricated
on the basis of superconducting PtSi film. A comparative study of the
properties of the chains, consisting of 3 and 20 SNS junctions in series, and
single SNS junctions reveals essential distinctions in the behavior of the
current-voltage characteristics of the systems: (i) the gradual decrease of the
effective suppression voltage for the excess conductivity observed at zero bias
as the quantity of the SNS junctions increases, (ii) a rich fine structure on
the dependences dV/dI-V at dc bias voltages higher than the superconducting gap
and corresponding to some multiples of 2\Delta/e. A model to explain this
above-energy-gap structure based on energy relaxation of electron via
Cooper-pair-breaking in superconducting island connecting normal metal
electrods is proposed.Comment: RevTex, 5 pages, 4 figure
Multiple Andreev Reflection and Giant Excess Noise in Diffusive Superconductor/Normal-Metal/Superconductor Junctions
We have studied superconductor/normal metal/superconductor (SNS) junctions
consisting of short Au or Cu wires between Nb or Al banks. The Nb based
junctions display inherent electron heating effects induced by the high thermal
resistance of the NS boundaries. The Al based junctions show in addition
subharmonic gap structures in the differential conductance dI/dV and a
pronounced peak in the excess noise at very low voltages V. We suggest that the
noise peak is caused by fluctuations of the supercurrent at the onset of
Josephson coupling between the superconducting banks. At intermediate
temperatures where the supercurrent is suppressed a noise contribution ~1/V
remains, which may be interpreted as shot noise originating from large multiple
charges.Comment: 7 pages, 7 figures, extended versio
Stability and Antioxidant Activity of Hydro-Glyceric Extracts Obtained from Different Grape Seed Varieties Incorporated in Cosmetic Creams
Grape seeds are agro-industrial by-products, which if improperly managed, may be responsible for socioeconomic and environmental problems. Nevertheless, it is possible to effectively valorize them by means of extraction of the bioactive compounds, especially the antioxidant phenolic molecules, using a safe, green, and environmentally-friendly extractive medium (i.e., hydro-glyceric solution). In the present study, the extraction was performed using seeds from two Lebanese varieties, Obeidi and Asswad Karech, and three international varieties, Marselan, Syrah, and Cabernet Franc. The type and amount of phenolic compounds were identified by High-Performance Liquid Chromatography (HPLC). Marselan was the extract richer in catechins (132.99 +/- 9.81 mu g/g of dried matter), and it also contained a higher amount of phenolic compounds (49.08 +/- 0.03 mg of gallic acid equivalent/g of dry matter and 10.02 +/- 0.24 mg of proanthocyanidin content/g of dry matter). The antioxidant capacity of the extracts was assessed using three different colorimetric assays including 2,2-DiPhenyl-1-PicrylHydrazyl (DPPH), CUPRIC ion Reducing Antioxidant Capacity (CUPRAC), and Ferric Reducing Antioxidant Power (FRAP). As expected, Marselan exhibited the highest antioxidant activity; as well, the total phenolic and proanthocyanidin content were the highest. The stability of the Marselan extract incorporated into a commercial cream, was performed at three different temperatures (4, 25, and 50 degrees C), and four different concentrations (5, 4, 3, 2%), over a period of 4 months, using different methods such as centrifugation, Heat-Shock Cycles, pH, and viscosity. All Marselan hydro-glyceric extract formulations were proven to be stable over the entire 4 months, where the highest stability was achieved at 4 degrees C and the least at 50 degrees C. This study supports the suitability of the incorporation of phenolic extracts into commercial creams to enrich the cosmetic industry with effective, natural, and safe skincare products
Full Current Statistics in Diffusive Normal-Superconductor Structures
We study the current statistics in normal diffusive conductors in contact
with a superconductor. Using an extension of the Keldysh Green's function
method we are able to find the full distribution of charge transfers for all
temperatures and voltages. For the non-Gaussian regime, we show that the
equilibrium current fluctuations are enhanced by the presence of the
superconductor. We predict an enhancement of the nonequilibrium current noise
for temperatures below and voltages of the order of the Thouless energy
E_Th=D/L^2. Our calculation fully accounts for the proximity effect in the
normal metal and agrees with experimental data. We demonstrate that the
calculation of the full current statistics is in fact simpler than a concrete
calculation of the noise.Comment: 4 pages, 2 figures (included
Coherent low-energy charge transport in a diffusive S-N-S junction
We have studied the current voltage characteristics of diffusive mesoscopic
Nb-Cu-Nb Josephson junctions with highly-transparent Nb-Cu interfaces. We
consider the low-voltage and high-temperature regime eV<\epsilon_{c}<k_{B}T
where epsilon_{c} is the Thouless energy. The observed excess current as well
as the observed sub-harmonic Shapiro steps under microwave irradiation suggest
the occurrence of low-energy coherent Multiple Andreev Reflection (MAR).Comment: 4 pages, 4 figures, final versio
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