Impulse oscillometry identifies peripheral airway dysfunction in children with adenosine deaminase deficiency.

Adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID) is characterized by impaired T-, B- and NK-cell function. Affected children, in addition to early onset of infections, manifest non-immunologic symptoms including pulmonary dysfunction likely attributable to elevated systemic adenosine levels. Lung disease assessment has primarily employed repetitive radiography and effort-dependent functional studies. Through impulse oscillometry (IOS), which is effort-independent, we prospectively obtained objective measures of lung dysfunction in 10 children with ADA-SCID. These results support the use of IOS in the identification and monitoring of lung function abnormalities in children with primary immunodeficiencies

A new perturbation treatment applied to the transport through a quantum dot

Resonant tunnelling through an Anderson impurity is investigated by employing a new perturbation scheme at nonequilibrium. This new approach gives the correct weak and strong coupling limit in $U$ by introducing adjustable parameters in the self-energy and imposing self-consistency of the occupation number of the impurity. We have found that the zero-temperature linear response conductance agrees well with that obtained from the exact sum rule. At finite temperature the conductance shows a nonzero minimum at the Kondo valley, as shown in recent experiments. The effects of an applied bias voltage on the single-particle density of states and on the differential conductances are discussed for Kondo and non-Kondo systems.Comment: 4 pages, 4 figures, submitted to PRB-Rapid Comm. Email addresses [email protected], [email protected]

Theory of Scanning Tunneling Spectroscopy of a Magnetic Adatom on a Metallic Surface

A comprehensive theory is presented for the voltage, temperature, and spatial dependence of the tunneling current between a scanning tunneling microscope (STM) tip and a metallic surface with an individual magnetic adatom. Modeling the adatom by a nondegenerate Anderson impurity, a general expression is derived for a weak tunneling current in terms of the dressed impurity Green function, the impurity-free surface Green function, and the tunneling matrix elements. This generalizes Fano's analysis to the interacting case. The differential-conductance lineshapes seen in recent STM experiments with the tip directly over the magnetic adatom are reproduced within our model, as is the rapid decay, \sim 10\AA, of the low-bias structure as one moves the tip away from the adatom. With our simple model for the electronic structure of the surface, there is no dip in the differential conductance at approximately one lattice spacing from the magnetic adatom, but rather we see a resonant enhancement. The formalism for tunneling into small clusters of magnetic adatoms is developed.Comment: 12 pages, 9 figures; to appear in Phys. Rev.

Modified Perturbation Theory Applied to Kondo-Type Transport through a Quantum Dot under a Magnetic Field

Linear conductance through a quantum dot is calculated under a finite magnetic field using the modified perturbation theory. The method is based on the second-order perturbation theory with respect to the Coulomb repulsion, but the self-energy is modified to reproduce the correct atomic limit and to fulfill the Friedel sum rule exactly. Although this method is applicable only to zero temperature in a strict sense, it is approximately extended to finite temperatures. It is found that the conductance near electron-hole symmetry is suppressed by the application of the magnetic field at low temperatures. Positive magnetoconductance is observed in the case of large electron-hole asymmetry.Comment: 4pages, 5 figure

Transport through Quantum Dots: Analytic Results from Integrability

Recent experiments have probed quantum dots through transport measurements in the regime where they are described by a two lead Anderson model. In this paper we develop a new method to analytically compute for the first time the corresponding transport properties. This is done by using the exact solvability of the Anderson Hamiltonian, together with a generalization of the Landauer-Buttiker approach to integrable systems. The latter requires proper identification of scattering states, a complex and crucial step in our approach. In the Kondo regime, our results include the zero-field, finite temperature linear response conductance, as well as the zero-temperature, non-equilibrium conductance in an applied Zeeman field.Comment: 5 pages, 3 figure

Mesoscopic Kondo Effect in an Aharonov-Bohm Ring

An interacting quantum dot inserted in a mesoscopic ring is investigated. A variational ansatz is employed to describe the ground state of the system in the presence of the Aharonov-Bohm flux. It is shown that, for even number of electrons with the energy level spacing smaller than the Kondo temperature, the persistent current has a value similar to that of a perfect ring with the same radius. On the other hand, for a ring with odd number electrons, the persistent current is found to be strongly suppressed compared to that of an ideal ring, which implies the suppression of the Kondo-resonant transmission. Various aspects of the Kondo-assisted persistent current are discussed.Comment: 4 pages Revtex, 4 Postscript figures, final version to appear in Phys. Rev. Lett. 85, No.26 (Dec. 25, 2000

Many-Body Approch to Spin-Dependent Transport in Quantum Dot Systems

By means of a diagram technique for Hubbard operators we show the existence of a spin-dependent renormalization of the localized levels in an interacting region, e.g. quantum dot, modeled by the Anderson Hamiltonian with two conduction bands. It is shown that the renormalization of the levels with a given spin direction is due to kinematic interactions with the conduction sub-bands of the opposite spin. The consequence of this dressing of the localized levels is a drastically decreased tunneling current for ferromagnetically ordered leads compared to that of paramagnetically ordered leads. Furthermore, the studied system shows a spin-dependent resonant tunneling behaviour for ferromagnetically ordered leads.Comment: 8 pages, 5 figure

Mesoscopic transport beyond linear response

We present an approach to steady-state mesoscopic transport based on the maximum entropy principle formulation of nonequilibrium statistical mechanics. Our approach is not limited to the linear response regime. We show that this approach yields the quantization observed in the integer quantum Hall effect at large currents, which until now has been unexplained. We also predict new behaviors of non-local resistances at large currents in the presence of dirty contacts.Comment: 14 pages plus one figure (with an insert) (post-script codes appended), RevTeX 3.0, UCF-CM-93-004 (Revised