Omnidirectional acceleration device Patent

Omnidirectional liquid filled accelerometer design with liquid and housing temperature compensatio

Hydrodynamic Simulations of Oscillating Shock Waves in a Sub-Keplerian Accretion Flow Around Black Holes

We study the accretion processes on a black hole by numerical simulation. We use a grid based finite difference code for this purpose. We scan the parameter space spanned by the specific energy and the angular momentum and compare the time-dependent solutions with those obtained from theoretical considerations. We found several important results (a) The time dependent flow behaves close to a constant height model flow in the pre-shock region and a flow with vertical equilibrium in the post-shock region. (c) The infall time scale in the post-shock region is several times higher than the free-fall time scale. (b) There are two discontinuities in the flow, one being just outside of the inner sonic point. Turbulence plays a major role in determining the locations of these discontinuities. (d) The two discontinuities oscillate with two different frequencies and behave as a coupled harmonic oscillator. A Fourier analysis of the variation of the outer shock location indicates higher power at the lower frequency and lower power at the higher frequency. The opposite is true when the analysis of the inner shock is made. These behaviours will have implications in the spectral and timing properties of black hole candidates.Comment: 19 pages, 13 figures, 1 Table MNRAS (In press

Tight focal spots using azimuthally polarised light from a Fresnel cone

When focusing a light beam at high numerical aperture, the resulting electric field profile in the focal plane depends on the transverse polarisation profile, as interference between different parts of the beam needs to be taken into account. It is well known that radial polarised light produces a longitudinal polarisation component and can be focused below the conventional diffraction limit for homogeneously polarised light, and azimuthally polarised light that carries one unit of angular momentum can achieve even tighter focal spots. This is of interest for example for enhancing resolution in scanning microscopy. There are numerous ways to generate such polarisation structures, however, setups can be expensive and usually rely on birefringent components, hence prohibiting broadband operation. We have recently demonstrated a passive, low-cost technique using a simple glass cone (Fresnel cone) to generate beams with structured polarisation. We show here that the polarisation structure generated by Fresnel cones focuses better than radial polarised light at all numerical apertures. Furthermore, we investigate in detail the application of polarised light structures for two-photon microscopy. Specifically we demonstrate a method that allows us to generate the desired polarisation structure at the back aperture of the microscope by pre-compensating any detrimental phase shifts using a combination of waveplates

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser(487) in the ‘ST loop’ (serine/threonine-rich loop) within the C-terminal domain of AMPK-α1 (AMP-activated protein kinase-α1), leading to inhibition of phosphorylation by upstream kinases at the activating site, Thr(172). Surprisingly, the equivalent site on AMPK-α2, Ser(491), is not an Akt target and is modified instead by autophosphorylation. Stimulation of HEK (human embryonic kidney)-293 cells with IGF-1 caused reduced subsequent Thr(172) phosphorylation and activation of AMPK-α1 in response to the activator A769662 and the Ca(2+) ionophore A23187, effects we show to be dependent on Akt activation and Ser(487) phosphorylation. Consistent with this, in three PTEN (phosphatase and tensin homologue deleted on chromosome 10)-null tumour cell lines (in which the lipid phosphatase PTEN that normally restrains the Akt pathway is absent and Akt is thus hyperactivated), AMPK was resistant to activation by A769662. However, full AMPK activation could be restored by pharmacological inhibition of Akt, or by re-expression of active PTEN. We also show that inhibition of Thr(172) phosphorylation is due to interaction of the phosphorylated ST loop with basic side chains within the αC-helix of the kinase domain. Our findings reveal that a previously unrecognized effect of hyperactivation of Akt in tumour cells is to restrain activation of the LKB1 (liver kinase B1)–AMPK pathway, which would otherwise inhibit cell growth and proliferation

Laser diode initiated detonators for space applications

Ensign Bickford Aerospace Company (EBAC) has over ten years of experience in the design and development of laser ordnance systems. Recent efforts have focused on the development of laser diode ordnance systems for space applications. Because the laser initiated detonators contain only insensitive secondary explosives, a high degree of system safety is achieved. Typical performance characteristics of a laser diode initiated detonator are described in this paper, including all-fire level, function time, and output. A finite difference model used at EBAC to predict detonator performance, is described and calculated results are compared to experimental data. Finally, the use of statistically designed experiments to evaluate performance of laser initiated detonators is discussed

Magnetically Driven Jets in the Kerr Metric

We compute a series of three-dimensional general relativistic magnetohydrodynamic simulations of accretion flows in the Kerr metric to investigate the properties of the unbound outflows that result. The overall strength of these outflows increases sharply with increasing black hole rotation rate, but a number of generic features are found in all cases. The mass in the outflow is concentrated in a hollow cone whose opening angle is largely determined by the effective potential for matter orbiting with angular momentum comparable to that of the innermost stable circular orbit. The dominant force accelerating the matter outward comes from the pressure of the accretion disk's corona. The principal element that shapes the outflow is therefore the centrifugal barrier preventing accreting matter from coming close to the rotation axis. Inside the centrifugal barrier, the cone contains very little matter and is dominated by electromagnetic fields that rotate at a rate tied closely to the rotation of the black hole. These fields carry an outward-going Poynting flux whose immediate energy source is the rotating spacetime of the Kerr black hole. When the spin parameter a/M of the black hole exceeds ~0.9, the energy carried to infinity by these outflows can be comparable to the nominal radiative efficiency predicted in the Novikov-Thorne model. Similarly, the expelled angular momentum can be comparable to that accreted by the black hole. Both the inner electromagnetic part and the outer matter part can contribute in significant fashion to the energy and angular momentum of the outflow.Comment: 43 pages 12 figures To Appear in the Astrophysical Journal replaced figure 3c with correct imag