Role of Angiotensin II in Hemorrhagic Hypotension in the Rat

Author Institution: Department of Physiology, Wright State UniversityThe purpose of this study was to evaluate the role of the renin-angiotensin system in the acute regulation of blood pressure following hemorrhage in the anesthetized rat. Eleven Sprague-Dawley rats were anesthetized with sodium pentobarbital. After control blood pressure recordings from the femoral artery were made, the rats were hemorrhaged 6 ml/kg body weight. Forty minutes after hemorrhage, the Angiotensin II antagonist, l-SAR-8-ALA-Angiotensin II (saralasin), was infused (10 /Ltg/min/kg) for 35 min. Hemorrhage resulted in a 53% decrease in blood pressure which recovered to 82% of the control blood pressure in 40 minutes. Infusion of saralasin resulted in a 24% decrease (p <0.01) in blood pressure within 15 min. Recovery from saralasin infusion occurred within 10 min as blood pressure increased back to control values. A second group of 5 rats was not hemorrhaged but was infused with saralasin. There were no significant changes in blood pressure; although, a tendency to decrease was noted reflecting the increase in plasma renin activity which occurs with anesthesia. It was concluded that the renin-angiotensin system can respond rapidly to a hypotensive event and aid in the restoration of blood pressure within minutes

Mendocino power plant site ecological study final report

A preoperational ecological study of a proposed nuclear power plant site on the Mendocino County coast was initiated in September 1971. The study resulted from an agreement between the Pacific Gas and Electric Company and the California Department of Fish and Game signed in July 1971. In the agreement, Pacific Gas and Electric Company provided funds for the Department's studies of the site. Studies of the subtidal animal and plant communities were conducted by divers from September 1971 through March 1973; intertidal animal and plant populations were surveyed from November 1971 through February 1973. Sportfisheries for abalone and finfish were surveyed during 1972 and Spring of 1973. Stomach contents of many of the more abundant subtidal and intertidal fishes were examined. All of these studies were designed to determine the dominant species of plants, invertebrates and fishes in the various communities, their relative abundance, and where applicable, size composition, predators and competitors. The parameters developed from these studies would be used for comparison with similar studies conducted after the proposed plant went into operation to determine what effect construction and operation of the plant might have on the various plants and animals studied. (291pp.

Diablo Canyon power plant site ecological study annual report; July 1, 1973 - June 30, 1974

We completed surveys of 11 permanent subtidal stations, 17 random subtidal stations, 4 permanent intertidal stations, and 29 random intertidal stations during the period. In addition, we conducted studies on the sea otter, Enhydra lutris, herd located between Diablo Cove and Point Buchon, continued the annual count of the mature bed of the bull kelp, Nereocystis luetkeana, within Diablo Cove, and interviewed commercial abalone and sea urchin divers for catch-per-unit-of-effort data. During the year, sea otters moved south into the cove east of Lion Rock and then into Diablo Cove. (107pp.) The commercial abalone fishery showed signs of decline, while the commercial sea urchin fishery continued to expand. Several diving surveys were conducted inside Intake Cove to check on dredging progress; the cove appears to have become a haven for juvenile rockfish (Sebastes). The red abalone temperature tolerance studies were completed at the Department's marine culture laboratory at Granite Canyon

A multivariate analysis of serum nutrient levels and lung function

<p>Abstract</p> <p>Background</p> <p>There is mounting evidence that estimates of intakes of a range of dietary nutrients are related to both lung function level and rate of decline, but far less evidence on the relation between lung function and objective measures of serum levels of individual nutrients. The aim of this study was to conduct a comprehensive examination of the independent associations of a wide range of serum markers of nutritional status with lung function, measured as the one-second forced expiratory volume (FEV₁).</p> <p>Methods</p> <p>Using data from the Third National Health and Nutrition Examination Survey, a US population-based cross-sectional study, we investigated the relation between 21 serum markers of potentially relevant nutrients and FEV₁, with adjustment for potential confounding factors. Systematic approaches were used to guide the analysis.</p> <p>Results</p> <p>In a mutually adjusted model, higher serum levels of antioxidant vitamins (vitamin A, beta-cryptoxanthin, vitamin C, vitamin E), selenium, normalized calcium, chloride, and iron were independently associated with higher levels of FEV₁. Higher concentrations of potassium and sodium were associated with lower FEV₁.</p> <p>Conclusion</p> <p>Maintaining higher serum concentrations of dietary antioxidant vitamins and selenium is potentially beneficial to lung health. In addition other novel associations found in this study merit further investigation.</p