A Socio-technical Analysis of Interdependent Infrastructures among the Built Environment, Energy, and Transportation Systems at the Navy Yard and the Philadelphia Metropolitan Region, USA

This paper reports on a research initiative that explores the interdependencies of the system of systems — the built environment, energy, and transportation — related to the redevelopment of The Navy Yard in Philadelphia and the Philadelphia Metropolitan Region. The overarching goal of the project is a clearer understanding of the dynamics of multi-scale interactions and interdependencies of systems of sociotechnical systems that will be useful to system practitioners. The understanding and the subsequent planning and design of sociotechnical systems are “wicked” problems and one characteristic is there is no definitive formulation. One of the main findings or lessons learned of the work reported for the understanding of interdependencies of infrastructure is the identification of what are the problems or challenges because for wicked problems “[t]he formulation of the problem is the problem!” We find that systems practitioners have an overarching concern of a fragmented regional policy and decision making process. Four main themes of 1. Vulnerability of aging infrastructure, 2. Integration of emerging technology into existing infrastructure, 3. Lifestyle and value changes, and 4. Financial innovations were identified as challenges. Continuing research work explores three possible infrastructure projects for further study as well as the development of a high-level systems of systems model. The principle outcome is the initiation of a planning process so that the system practitioners will learn to better understand the connections among related sociotechnical systems and the constellation of problems they face not within their immediate scope of responsibility yet influences the operations of their systems

Cyclic AMP modulation of ion transport across frog retinal pigment epithelium. Measurements in the short-circuit state.

In the frog retinal pigment epithelium (RPE), the cellular levels of cyclic AMP (cAMP) were measured in control conditions and after treatment with substances that are known to inhibit phosphodiesterase (PDE) activity (isobutyl-1-methylxanthine, SQ65442) or stimulate adenylate cyclase activity (forskolin). The cAMP levels were elevated by a factor of 5-7 compared with the controls in PDE-treated tissues and by a factor of 18 in forskolin-treated tissues. The exogenous application of cAMP (1 mM), PDE inhibitors (0.5 mM), or forskolin (0.1 mM) all produced similar changes in epithelial electrical parameters, such as transepithelial potential (TEP) and resistance (Rt), as well as changes in active ion transport. Adding 1 mM cAMP to the solution bathing the apical membrane transiently increased the short-circuit current (SCC) and the TEP (apical side positive) and decreased Rt. Microelectrode experiments showed that the elevation in TEP is due mainly to a depolarization of the basal membrane followed by, and perhaps also accompanied by, a smaller hyperpolarization of the apical membrane. The ratio of the apical to the basolateral membrane resistance increased in the presence of cAMP, and this increase, coupled with the decrease in Rt and the basolateral membrane depolarization, is consistent with a conductance increase at the basolateral membrane. Radioactive tracer experiments showed that cAMP increased the active secretion of Na (choroid to retina) and the active absorption of K (retina to choroid). Cyclic AMP also abolished the active absorption of Cl across the RPE. In sum, elevated cellular levels of cAMP affect active and passive transport mechanisms at the apical and basolateral membranes of the bullfrog RPE

L^2 torsion without the determinant class condition and extended L^2 cohomology

We associate determinant lines to objects of the extended abelian category built out of a von Neumann category with a trace. Using this we suggest constructions of the combinatorial and the analytic L^2 torsions which, unlike the work of the previous authors, requires no additional assumptions; in particular we do not impose the determinant class condition. The resulting torsions are elements of the determinant line of the extended L^2 cohomology. Under the determinant class assumption the L^2 torsions of this paper specialize to the invariants studied in our previous work. Applying a recent theorem of D. Burghelea, L. Friedlander and T. Kappeler we obtain a Cheeger - Muller type theorem stating the equality between the combinatorial and the analytic L^2 torsions.Comment: 39 page

Low Velocity Granular Drag in Reduced Gravity

We probe the dependence of the low velocity drag force in granular materials on the effective gravitational acceleration (geff) through studies of spherical granular materials saturated within fluids of varying density. We vary geff by a factor of 20, and we find that the granular drag is proportional to geff, i.e., that the granular drag follows the expected relation Fprobe = {\eta} {\rho}grain geff dprobe hprobe^2 for the drag force, Fprobe on a vertical cylinder with depth of insertion, hprobe, diameter dprobe, moving through grains of density {\rho}grain, and where {\eta} is a dimensionless constant. This dimensionless constant shows no systematic variation over four orders of magnitude in effective grain weight, demonstrating that the relation holds over that entire range to within the precision of our data

Topology of parametrised motion planning algorithms

We introduce and study a new concept of parameterised topological complexity, a topological invariant motivated by the motion planning problem of robotics. In the parametrised setting, a motion planning algorithm has high degree of universality and flexibility, it can function under a variety of external conditions (such as positions of the obstacles etc). We explicitly compute the parameterised topological complexity of obstacle-avoiding collision-free motion of many particles (robots) in 3-dimensional space. Our results show that the parameterised topological complexity can be significantly higher than the standard (nonparametrised) invariant

MIRAGE: A Model for Ultra-High-Speed Protocol Analysis and Design

Current protocols are expected to become inefficient if used at speeds in excess of 1 Gigabit per second. While this premise is widely accepted, no model exists to explain the phenomenon. We define a model for understanding protocols which is aimed at explaining why such a barrier exists, and indicates alternate designs which do not have this limit. Existing protocols are akin to classical mechanics; 1 Gigabit/second is the speed near which relativistic effects emerge. In order to account for these effects, we need to express knowledge at a distance, latent measurement, and uncertainty as real entities, not negligible estimates. The result is a model which expresses not only existing protocols, and may contribute to a better understanding of the Gigabit communications domain

Genetic and epigenetic regulation of abdominal aortic aneurysms

Abdominal aortic aneurysms (AAAs) are focal dilations of the aorta that develop from degenerative changes in the media and adventitia of the vessel. Ruptured AAAs have a mortality of up to 85%, thus it is important to identify patients with AAA at increased risk for rupture who would benefit from increased surveillance and/or surgical repair. Although the exact genetic and epigenetic mechanisms regulating AAA formation are not completely understood, Mendelian cases of AAA, which result from pathologic variants in a single gene, have helped provide a basic understanding of AAA pathophysiology. More recently, genome wide associated studies (GWAS) have identified additional variants, termed single nucleotide polymorphisms, in humans that may be associated with AAAs. While some variants may be associated with AAAs and play causal roles in aneurysm pathogenesis, it should be emphasized that the majority of SNPs do not actually cause disease. In addition to GWAS, other studies have uncovered epigenetic causes of disease that regulate expression of genes known to be important in AAA pathogenesis. This review describes many of these genetic and epigenetic contributors of AAAs, which altogether provide a deeper insight into AAA pathogenesis.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155527/1/cge13705.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155527/2/cge13705_am.pd

Critical points and resonance of hyperplane arrangements

If F is a master function corresponding to a hyperplane arrangement A and a collection of weights y, we investigate the relationship between the critical set of F, the variety defined by the vanishing of the one-form w = d log F, and the resonance of y. For arrangements satisfying certain conditions, we show that if y is resonant in dimension p, then the critical set of F has codimension at most p. These include all free arrangements and all rank 3 arrangements.Comment: revised version, Canadian Journal of Mathematics, to appea

Geometric and homological finiteness in free abelian covers

We describe some of the connections between the Bieri-Neumann-Strebel-Renz invariants, the Dwyer-Fried invariants, and the cohomology support loci of a space X. Under suitable hypotheses, the geometric and homological finiteness properties of regular, free abelian covers of X can be expressed in terms of the resonance varieties, extracted from the cohomology ring of X. In general, though, translated components in the characteristic varieties affect the answer. We illustrate this theory in the setting of toric complexes, as well as smooth, complex projective and quasi-projective varieties, with special emphasis on configuration spaces of Riemann surfaces and complements of hyperplane arrangements.Comment: 30 pages; to appear in Configuration Spaces: Geometry, Combinatorics and Topology (Centro De Giorgi, 2010), Edizioni della Normale, Pisa, 201