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Dust devils on Mars: Effects of surface roughness on particle threshold
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Gene expression differs in susceptible and resistant amphibians exposed to Batrachochytrium dendrobatidis.
Chytridiomycosis, the disease caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has devastated global amphibian biodiversity. Nevertheless, some hosts avoid disease after Bd exposure even as others experience near-complete extirpation. It remains unclear whether the amphibian adaptive immune system plays a role in Bd defence. Here, we describe gene expression in two host species-one susceptible to chytridiomycosis and one resistant-following exposure to two Bd isolates that differ in virulence. Susceptible wood frogs (Rana sylvatica) had high infection loads and mortality when exposed to the more virulent Bd isolate but lower infection loads and no fatal disease when exposed to the less virulent isolate. Resistant American bullfrogs (R. catesbeiana) had high survival across treatments and rapidly cleared Bd infection or avoided infection entirely. We found widespread upregulation of adaptive immune genes and downregulation of important metabolic and cellular maintenance components in wood frogs after Bd exposure, whereas American bullfrogs showed little gene expression change and no evidence of an adaptive immune response. Wood frog responses suggest that adaptive immune defences may be ineffective against virulent Bd isolates that can cause rapid physiological dysfunction. By contrast, American bullfrogs exhibited robust resistance to Bd that is likely attributable, at least in part, to their continued upkeep of metabolic and skin integrity pathways as well as greater antimicrobial peptide expression compared to wood frogs, regardless of exposure. Greater understanding of these defences will ultimately help conservationists manage chytridiomycosis
The excited hadron spectrum in lattice QCD using a new method of estimating quark propagation
Progress in determining the spectrum of excited baryons and mesons in lattice
QCD is described. Large sets of carefully-designed hadron operators have been
studied and their effectiveness in facilitating the extraction of excited-state
energies is demonstrated. A new method of stochastically estimating the
low-lying effects of quark propagation is proposed which will allow reliable
determinations of temporal correlations of single-hadron and multi-hadron
operators.Comment: 5 pages, 4 figures, talk given at Hadron 2009, Tallahassee, Florida,
December 1, 200
Examining cost measurements in production and delivery of three case studies using eLearning for Applied Health Sciences: a cross-case synthesis
The World Health Organization World Health Report conveys that a significant increase is needed in global healthcare resourcing to meet current and future demand for health professionals. eLearning presents a possible opportunity to change and optimize training by providing a scalable means for instruction, thus reducing the costs for training health professionals and providing patient education. Research literature often suggests that a benefit of eLearning is its cost-effectiveness compared with face-to-face instruction, yet there is limited evidence comparing design and production costs with other forms of instruction, or the establishment of standards for budgeting for these costs
Children's suggestibility in relation to their understanding about sources of knowledge
In the experiments reported here, children chose either to maintain their initial belief about an object's identity or to accept the experimenter's contradicting suggestion. Both 3– to 4–year–olds and 4– to 5–year–olds were good at accepting the suggestion only when the experimenter was better informed than they were (implicit source monitoring). They were less accurate at recalling both their own and the experimenter's information access (explicit recall of experience), though they performed well above chance. Children were least accurate at reporting whether their final belief was based on what they were told or on what they experienced directly (explicit source monitoring). Contrasting results emerged when children decided between contradictory suggestions from two differentially informed adults: Three– to 4–year–olds were more accurate at reporting the knowledge source of the adult they believed than at deciding which suggestion was reliable. Decision making in this observation task may require reflective understanding akin to that required for explicit source judgments when the child participates in the task
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